(Q37867729)

24 August 2017

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title

COP9 signalosome function in the DDR. (English)

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24 August 2017

Ronny Hannss

1

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24 August 2017

Wolfgang Dubiel

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

16 April 2011

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24 August 2017

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24 August 2017

volume

585

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24 August 2017

issue

18

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24 August 2017

page(s)

2845-2852

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The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch

24 August 2017

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Mammalian COP9 signalosome

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The COP9 signalosome: more than a protease

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The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response.

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Multiple functions of Jab1 are required for early embryonic development and growth potential in mice

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Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death

21 January 2018

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COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast

21 January 2018

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COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

21 January 2018

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RING domain E3 ubiquitin ligases

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Function and regulation of cullin-RING ubiquitin ligases

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Revisiting the COP9 signalosome as a transcriptional regulator

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Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes

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Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms

21 January 2018

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Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins

21 January 2018

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

21 January 2018

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Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo

21 January 2018

1 reference

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21 January 2018

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An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases

21 January 2018

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Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

21 January 2018

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Ubiquitin system: JAMMing in the name of the lid.

21 January 2018

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A cryptic protease couples deubiquitination and degradation by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Recognition and processing of ubiquitin-protein conjugates by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Genetic regulators of large-scale transcriptional signatures in cancer

21 January 2018

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CRL4s: the CUL4-RING E3 ubiquitin ligases

21 January 2018

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Ubiquitin proteasome system (UPS): what can chromatin do for you?

21 January 2018

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

21 January 2018

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Defining the human deubiquitinating enzyme interaction landscape

21 January 2018

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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

21 January 2018

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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

21 January 2018

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Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

21 January 2018

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

21 January 2018

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Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase

21 January 2018

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F-box-directed CRL complex assembly and regulation by the CSN and CAND1

21 January 2018

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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells

21 January 2018

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Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The ATM-mediated DNA-damage response: taking shape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Fungal development and the COP9 signalosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

1 reference

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DNA damage checkpoints: from initiation to recovery or adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

The CUL4 enigma: culling DNA repair factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DNA repair in terminally differentiated cells

21 January 2018

1 reference

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Characterization of DNA recognition by the human UV-damaged DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Here comes the sun: recognition of UV-damaged DNA.

21 January 2018

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Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

21 January 2018

1 reference

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DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells

21 January 2018

1 reference

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Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair

21 January 2018

1 reference

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CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

A new regulator of the cell cycle: the PR-Set7 histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Regulation of the anaphase-promoting complex by the COP9 signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DDB2 decides cell fate following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

DNA repair pathways as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.04.027

10.1016/J.FEBSLET.2011.04.027

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference