(Q37885731)

24 August 2017

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title

Emerging therapeutic targets in schwannomas and other merlin-deficient tumors (English)

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24 August 2017

Sylwia Ammoun

1

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24 August 2017

C Oliver Hanemann

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

7 June 2011

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24 August 2017

published in

Nature Reviews Neurology

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24 August 2017

volume

7

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24 August 2017

issue

7

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24 August 2017

page(s)

392-399

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2011.82

24 August 2017

exact match

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cites work

News on the genetics, epidemiology, medical care and translational research of Schwannomas

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

21 January 2018

Neurofibromatosis type 2

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Molecular targets for breast cancer therapy and prevention

21 January 2018

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Expression of ErbB-1 and 2 in vestibular schwannomas.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Structure-function relationships for the EGF/TGF-alpha family of mitogens

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Molecular cloning of mouse epiregulin, a novel epidermal growth factor-related protein, expressed in the early stage of development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Multiple essential functions of neuregulin in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Cell death in the Schwann cell lineage and its regulation by neuregulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Requirement for neuregulin receptor erbB2 in neural and cardiac development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Untangling the ErbB signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

ErbB receptors: from oncogenes to targeted cancer therapies

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Identification of molecular subtypes of glioblastoma by gene expression profiling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Expression of ErbB-1 and ErbB-2 in meningioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Cell adhesion regulates ubiquitin-mediated degradation of the platelet-derived growth factor receptor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Activation of ERK, AKT and JNK signalling pathways in human schwannomas in situ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Insulin-like growth factor-I and central nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The insulin-like growth factor system and its pleiotropic functions in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Schwann cells as regulators of nerve development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Regulation of rat Schwann cell Po expression and DNA synthesis by insulin-like growth factors in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Tumor angiogenesis: insights and innovations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

The role of neuropilins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Hearing improvement after bevacizumab in patients with neurofibromatosis type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

VEGF and VEGF receptor-1 concentration in vestibular schwannoma homogenates correlates to tumor growth rate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Expression of VEGF and its receptor genes in intracranial schwannomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Approval of new drugs for glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

ERM proteins and merlin: integrators at the cell cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Epidermal growth factor receptor is not amplified in schwannomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Mechanism of action and in vivo role of platelet-derived growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Establishment of adult rat Schwann cell cultures: effect of b-FGF, alpha-MSH, NGF, PDGF, and TGF-beta on cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Role of integrins in peripheral nerves and hereditary neuropathies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Expression of PDGF and its receptor as well as their relationship to proliferating activity and apoptosis of meningiomas in human meningiomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Alpha(v)beta3 and alpha(v)beta5 integrin expression in meningiomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected nerves and cultured Schwann cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Insulin-like growth factor-I promotes myelination of peripheral sensory axons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2011.82

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation

31 March 2020

1 reference

12 December 2020

Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2.

1 reference

12 December 2020

Neuregulin, a factor with many functions in the life of a schwann cell

1 reference

12 December 2020

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway

1 reference

12 December 2020

Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells

1 reference

12 December 2020

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer

1 reference

12 December 2020

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

1 reference

12 December 2020

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.

1 reference

12 December 2020

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

1 reference

12 December 2020

The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand.

1 reference

12 December 2020

Pathological adhesion of primary human schwannoma cells is dependent on altered expression of integrins.

1 reference

12 December 2020

Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation

1 reference

12 December 2020

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEUROL.2011.82

1 reference

Dimensions Publication ID

24 August 2017

1048660366

0 references

1 reference