(Q37890978)

24 August 2017

1 reference

title

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase (English)

1 reference

24 August 2017

Targeting COPD: advances on low‐molecular‐weight inhibitors of human neutrophil elastase (English)

1 reference

4 December 2024

1 reference

1

Susana D. Lucas

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21681767

4 December 2024

3

Rita C. Guedes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21681767

4 December 2024

4

Rui Moreira

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21681767

4 December 2024

author name string

Elsa Costa

2

1 reference

24 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21681767

4 December 2024

publication date

16 June 2011

1 reference

full work available at URL

24 August 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmed.20247

1 reference

https://onlinelibrary.wiley.com/doi/pdf/10.1002/med.20247

4 December 2024

1 reference

Medicinal Research Reviews

4 December 2024

published in

1 reference

24 August 2017

volume

33 Suppl 1

1 reference

24 August 2017

page(s)

E73-101

1 reference

On the size of the active site in proteases. I. Papain

24 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Synthesis and anti-elastase properties of 6-amino-2-phenyl-4H-3,1-benzoxazin-4-one aminoacyl and dipeptidyl derivatives

21 January 2018

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Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.

21 January 2018

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2-Amino- and 2-alkylthio-4H-3,1-benzothiazin-4-ones: synthesis, interconversion and enzyme inhibitory activities

21 January 2018

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Novel beta-lactam antibiotics derivatives: their new applications as gene reporters, antitumor prodrugs and enzyme inhibitors

21 January 2018

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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol

21 January 2018

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Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

21 January 2018

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Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

21 January 2018

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The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

21 January 2018

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Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

21 January 2018

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4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

21 January 2018

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Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design

21 January 2018

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Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety

21 January 2018

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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate

21 January 2018

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Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)

21 January 2018

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Synthetic inhibitors of elastase

21 January 2018

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Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs

21 January 2018

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Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase

21 January 2018

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Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury

21 January 2018

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Recent developments in the design of mechanism-based and alternate substrate inhibitors of serine proteases

21 January 2018

1 reference

The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor

21 January 2018

1 reference

Coumarin and isocoumarin as serine protease inhibitors.

21 January 2018

1 reference

Advances in the chemistry of saccharins: from synthetic novelties towards biologically active compounds

21 January 2018

1 reference

Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides

21 January 2018

1 reference

Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold

21 January 2018

1 reference

1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases

21 January 2018

1 reference

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

21 January 2018

1 reference

Potent and Specific Inhibition of Human Leukocyte Elastase, Cathepsin G and Proteinase 3 by Sulfone Derivatives Employing the 1,2,5-Thiadiazolidin-3-one 1,1 Dioxide Scaffold

21 January 2018

1 reference

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.

21 January 2018

1 reference

X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †

21 January 2018

1 reference

Dual function inhibitors of relevance to chronic obstructive pulmonary disease

21 January 2018

1 reference

Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold

21 January 2018

1 reference

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

21 January 2018

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Natural compounds as inhibitors of human neutrophil elastase

21 January 2018

1 reference

Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta

21 January 2018

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Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities

21 January 2018

1 reference

Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations

21 January 2018

1 reference

Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides

21 January 2018

1 reference

Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp.

21 January 2018

1 reference

New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase

21 January 2018

1 reference

Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis

21 January 2018

1 reference

Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore.

21 January 2018

1 reference

Inhibition of human leukocyte elastase by brunsvicamides a-C: cyanobacterial cyclic peptides.

21 January 2018

1 reference

Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase

21 January 2018

1 reference

Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches

21 January 2018

14

1 reference

Non-peptidic inhibitors of human neutrophil elastase: the design and synthesis of sulfonanilide-containing inhibitors

4 December 2024

25

1 reference

Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase

4 December 2024

34

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Novel Thieno[2,3-d][1,3]oxazin-4-ones as Inhibitors of Human Leukocyte Elastase

4 December 2024

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2-(diethylamino)thieno1,3ŏxazin-4-ones as stable inhibitors of human leukocyte elastase

4 December 2024

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Inhibition of Human Leucocyte Elastase by Novel Thieno-1,3-oxazin-4-ones and Thieno-1,3-thioxazin-4-ones

4 December 2024

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Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives

4 December 2024

46

1 reference

An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters

4 December 2024

47

1 reference

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

4 December 2024

51

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Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis

4 December 2024

53

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Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition

4 December 2024

60

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Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones

4 December 2024

67

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Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor

4 December 2024

68

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Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase

4 December 2024

74

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Active-site specific inhibitors of elastase

4 December 2024

76

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Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives

4 December 2024

81

1 reference

Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase

4 December 2024

82

1 reference

Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

4 December 2024

90

1 reference

Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide

4 December 2024

93

1 reference

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

4 December 2024

94

1 reference

Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa

4 December 2024

105

1 reference

Structure activity relationship studies of cinnamic acid derivatives as inhibitors of human neutrophil elastase revealed by ligand docking calculations

4 December 2024

107

1 reference

4 December 2024

Identifiers

DOI

10.1002/MED.20247

1 reference

24 August 2017

1 reference