(Q37903716)

English

Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs

scientific article published on 22 July 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

1 reference

Europe PubMed Central

Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

natural product

1 reference

based on heuristic

inferred from title

Andreas Hofmann

2

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Esther Kellenberger

1

object named as

Esther Kellenberger

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

author name string

Ronald J Quinn

3

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

22 July 2011

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Natural Product Reports

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

28

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

1483-1492

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Merging chemical and biological space: Structural mapping of enzyme binding pocket space.

1 reference

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Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

1 reference

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Natural products in drug discovery and development

1 reference

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Marine natural products and related compounds in clinical and advanced preclinical trials

1 reference

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Natural products as sources of new drugs over the period 1981-2002.

1 reference

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21 January 2018

Natural products as sources of new drugs over the last 25 years

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00026H

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Libraries from natural product-like scaffolds

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Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

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https://api.crossref.org/works/10.1039%2FC1NP00026H

21 January 2018

Modern methods to produce natural-product libraries

1 reference

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Relating protein pharmacology by ligand chemistry

1 reference

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Global mapping of pharmacological space

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Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

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Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.

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Compound library development guided by protein structure similarity clustering and natural product structure

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Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

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21 January 2018

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In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens

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21 January 2018

Why are secondary metabolites (natural products) biosynthesized?

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21 January 2018

The function of terpene natural products in the natural world

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The structure of the protein universe and genome evolution

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21 January 2018

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

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21 January 2018

A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

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Use of non-crystallographic symmetry in protein structure refinement

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The continuity of protein structure space is an intrinsic property of proteins

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Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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21 January 2018

sc-PDB: a database for identifying variations and multiplicity of 'druggable' binding sites in proteins

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Comprehensive evaluation of protein structure alignment methods: scoring by geometric measures.

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Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.

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Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine

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21 January 2018

Identifiers

10.1039/C1NP00026H

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

ResearchGate publication ID

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