(Q37924296)

25 August 2017

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title

Challenges in antimalarial drug discovery (English)

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25 August 2017

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1

Jeremy N Burrows

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25 August 2017

Didier Leroy

2

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PubMed ID

21879844

25 August 2017

Julie Lotharius

series ordinal

3

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PubMed ID

21879844

25 August 2017

David Waterson

series ordinal

4

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25 August 2017

1 September 2011

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Future Medicinal Chemistry

25 August 2017

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25 August 2017

3

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25 August 2017

11

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25 August 2017

1401-1412

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New medicines to improve control and contribute to the eradication of malaria

25 August 2017

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The global portfolio of new antimalarial medicines under development.

21 January 2018

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Medicines for Malaria Venture: sustaining antimalarial drug development

21 January 2018

1 reference

A Research Agenda to Underpin Malaria Eradication

21 January 2018

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Antimalarial drug discovery: efficacy models for compound screening

21 January 2018

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Thousands of chemical starting points for antimalarial lead identification

21 January 2018

1 reference

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

1 reference

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Reassessing models of hepatic extraction

21 January 2018

1 reference

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

21 January 2018

1 reference

The hERG channel and risk of drug-acquired cardiac arrhythmia: an overview

21 January 2018

1 reference

A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.

21 January 2018

1 reference

In vitro safety pharmacology profiling: what else beyond hERG?

21 January 2018

1 reference

Malaria, sexual development and transmission: retrospect and prospect

21 January 2018

1 reference

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

21 January 2018

1 reference

A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies

21 January 2018

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A high-throughput screen targeting malaria transmission stages opens new avenues for drug development

21 January 2018

1 reference

A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue

21 January 2018

1 reference

Plasmodium berghei: routine production of pure gametocytes, extracellular gametes, zygotes, and ookinetes

21 January 2018

1 reference

Effect of antimalarial drugs on Plasmodium falciparum gametocytes.

21 January 2018

1 reference

Complete development of hepatic stages of Plasmodium falciparum in vitro

21 January 2018

1 reference

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

21 January 2018

1 reference

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

21 January 2018

1 reference

Cultivation of the liver forms of Plasmodium vivax in human hepatocytes

21 January 2018

1 reference

Establishment of an in vitro assay for assessing the effects of drugs on the liver stages of Plasmodium vivax malaria

21 January 2018

1 reference

Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage.

21 January 2018

1 reference

Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites

21 January 2018

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New approach for high-throughput screening of drug activity on Plasmodium liver stages

21 January 2018

1 reference

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

21 January 2018

1 reference

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

21 January 2018

1 reference

Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys

21 January 2018

1 reference

Origins, practices and future of safety pharmacology

21 January 2018

1 reference

Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate

21 January 2018

1 reference

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum

21 January 2018

1 reference

Antimalarial dosing regimens and drug resistance

21 January 2018

1 reference

Variations in frequencies of drug resistance in Plasmodium falciparum

21 January 2018

1 reference

Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance.

21 January 2018

1 reference

Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.11.91

1 reference

25 August 2017

1 reference

PubMed ID

21879844