(Q37944537)

25 August 2017

title

New developments on the functions of coenzyme Q in mitochondria (English)

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25 August 2017

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Maria Luisa Genova

1

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25 August 2017

Giorgio Lenaz

series ordinal

2

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25 August 2017

language of work or name

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1 September 2011

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25 August 2017

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25 August 2017

volume

37

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25 August 2017

issue

5

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25 August 2017

page(s)

330-354

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Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject

25 August 2017

cites work

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Role of mobility of redox components in the inner mitochondrial membrane

21 January 2018

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On coenzyme Q orientation in membranes: A linear dichroism study of ubiquinones in a model bilayer

21 January 2018

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Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria

21 January 2018

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Quinone binding and reduction by respiratory complex I.

21 January 2018

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From protons to OXPHOS supercomplexes and Alzheimer's disease: structure-dynamics-function relationships of energy-transducing membranes

21 January 2018

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Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles.

21 January 2018

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Determination of the critical micelle concentration of short-chain ubiquinones in model systems

21 January 2018

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Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

21 January 2018

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Is ubiquinone diffusion rate-limiting for electron transfer?

21 January 2018

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The random collision model and a critical assessment of diffusion and collision in mitochondrial electron transport

21 January 2018

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Supercomplexes in the respiratory chains of yeast and mammalian mitochondria

21 January 2018

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Respiratory active mitochondrial supercomplexes.

21 January 2018

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Mitochondrial fatty acid oxidation and oxidative stress: lack of reverse electron transfer-associated production of reactive oxygen species

21 January 2018

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Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes

21 January 2018

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Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III

21 January 2018

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Architecture of active mammalian respiratory chain supercomplexes.

21 January 2018

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Three-dimensional structure of the respiratory chain supercomplex I1III2IV1 from bovine heart mitochondria.

21 January 2018

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Supramolecular organization of protein complexes in the mitochondrial inner membrane

21 January 2018

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Megacomplex organization of the oxidative phosphorylation system by structural analysis of respiratory supercomplexes from potato.

21 January 2018

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Large pore gels to separate mega protein complexes larger than 10 MDa by blue native electrophoresis: Isolation of putative respiratory strings or patches

21 January 2018

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Structure and function of mitochondrial supercomplexes

21 January 2018

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Effect of crosslinking cytochrome c oxidase.

21 January 2018

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Intra- and inter-complex cross-linking of subunits in the quinol oxidase super-complex from thermophilic Bacillus PS3.

21 January 2018

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The kinetics of the redox reactions of ubiquinone related to the electron-transport activity in the respiratory chain.

21 January 2018

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Further evidence for the pool function of ubiquinone as derived from the inhibition of the electron transport by antimycin.

21 January 2018

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Functional dynamic compartmentalization of respiratory chain intermediate substrates: implications for the control of energy production and mitochondrial diseases.

21 January 2018

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Metabolic channelling and control of the flux

21 January 2018

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The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis

21 January 2018

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Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

21 January 2018

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Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling

21 January 2018

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High resolution clear native electrophoresis for in-gel functional assays and fluorescence studies of membrane protein complexes.

21 January 2018

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Assembly of Respiratory Complexes I, III, and IV into NADH Oxidase Supercomplex Stabilizes Complex I in Paracoccus denitrificans

21 January 2018

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Chapter 10 Purification of the cytochrome C reductase/cytochrome C oxidase super complex of yeast mitochondria

21 January 2018

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Regulation of the mitochondrial permeability transition pore by ubiquinone analogs. A progress report

21 January 2018

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Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation

21 January 2018

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Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

21 January 2018

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The interaction between mitochondrial NADH-ubiquinone oxidoreductase and ubiquinol-cytochrome c oxidoreductase. Evidence for stoicheiometric association

21 January 2018

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The interaction between mitochondrial NADH-ubiquinone oxidoreductase and ubiquinol-cytochrome c oxidoreductase. Restoration of ubiquinone-pool behaviour

21 January 2018

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The respiratory chain in yeast behaves as a single functional unit

21 January 2018

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Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria

21 January 2018

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The mitochondrial and prokaryotic proton-translocating NADH:ubiquinone oxidoreductases: similarities and dissimilarities of the quinone-junction sites.

21 January 2018

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Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state

21 January 2018

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Natural distribution and occurrence of coenzyme Q homologues

21 January 2018

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An updating of the biochemical function of coenzyme Q in mitochondria.

21 January 2018

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Coenzyme Q and mitochondrial disease

21 January 2018

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Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue

21 January 2018

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Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates

21 January 2018

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Physiological significance of metabolite channelling: Author's response to commentaries

21 January 2018

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Mechanism for electron transfer within and between proteins

21 January 2018

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21 January 2018

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Extensive conformational sampling in a ternary electron transfer complex

21 January 2018

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Structures of quinone-binding sites in bc complexes: functional implications

21 January 2018

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Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction

21 January 2018

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Absence of large-scale displacement of quinone QB in bacterial photosynthetic reaction centers

21 January 2018

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Electrochemical and FTIR spectroscopic characterization of the cytochrome bc1 complex from Paracoccus denitrificans: evidence for protonation reactions coupled to quinone binding

21 January 2018

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The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase

21 January 2018

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Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production

21 January 2018

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Subunit positioning in photosystem II revisited.

21 January 2018

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The role of Coenzyme Q in mitochondrial electron transport

21 January 2018

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The Ubiquinone-binding Site in NADH:Ubiquinone Oxidoreductase from Escherichia coli

21 January 2018

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The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I.

21 January 2018

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Kinetics, control, and mechanism of ubiquinone reduction by the mammalian respiratory chain-linked NADH-ubiquinone reductase

21 January 2018

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The architecture of respiratory complex I

21 January 2018

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Characterization of the inhibitor binding site in mitochondrial NADH-ubiquinone oxidoreductase by photoaffinity labeling using a quinazoline-type inhibitor

21 January 2018

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Exploring the binding site of acetogenin in the ND1 subunit of bovine mitochondrial complex I.

21 January 2018

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Functional modules and structural basis of conformational coupling in mitochondrial complex I.

21 January 2018

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Exploring the inhibitor binding pocket of respiratory complex I.

21 January 2018

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The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction

21 January 2018

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Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase

21 January 2018

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Direct localization of the 51 and 24 kDa subunits of mitochondrial complex I by three-dimensional difference imaging

21 January 2018

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The protonmotive Q cycle: A general formulation

21 January 2018

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Structure-function of the cytochrome b6f complex.

21 January 2018

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21 January 2018

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The quinone chemistry of bc complexes

21 January 2018

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Protonmotive pathways and mechanisms in the cytochrome bc1 complex

21 January 2018

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Bifurcated ubihydroquinone oxidation in the cytochrome bc1 complex by proton-gated charge transfer.

21 January 2018

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Activated Q-cycle as a common mechanism for cytochrome bc1 and cytochrome b6f complexes

21 January 2018

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The Q-cycle reviewed: How well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex?

21 January 2018

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Structure-function studies of iron-sulfur clusters and semiquinones in the NADH-Q oxidoreductase segment of the respiratory chain

21 January 2018

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Iron-sulfur clusters/semiquinones in complex I.

21 January 2018

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Full recovery of the NADH:ubiquinone activity of complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica by the addition of phospholipids

21 January 2018

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Characterization of the delta muH+-sensitive ubisemiquinone species (SQ(Nf)) and the interaction with cluster N2: new insight into the energy-coupled electron transfer in complex I.

21 January 2018

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Energy converting NADH:quinone oxidoreductase (complex I).

21 January 2018

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Conformation-driven and semiquinone-gated proton-pump mechanism in the NADH-ubiquinone oxidoreductase (complex I).

21 January 2018

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Energy transduction by respiratory complex I--an evaluation of current knowledge

21 January 2018

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The proton-translocating NADH-quinone oxidoreductase in the respiratory chain: the secret unlocked

21 January 2018

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Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism?

21 January 2018

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Mitochondrial Complex I: structural and functional aspects

21 January 2018

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Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species

21 January 2018

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Organization of iron-sulfur clusters in respiratory complex I.

21 January 2018

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Were there any "misassignments" among iron-sulfur clusters N4, N5 and N6b in NADH-quinone oxidoreductase (complex I)?

21 January 2018

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Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance

21 January 2018

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Proton-coupled electron transfer at the Qo-site of the bc1 complex controls the rate of ubihydroquinone oxidation

21 January 2018

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Proton pumping in the bc1 complex: a new gating mechanism that prevents short circuits

21 January 2018

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The origin of cluster N2 of the energy-transducing NADH-quinone oxidoreductase: comparisons of phylogenetically related enzymes

21 January 2018

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Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism?

21 January 2018

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Complex I: a chimaera of a redox and conformation-driven proton pump?

21 January 2018

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Respiratory complex I: structure, redox components, and possible mechanisms of energy transduction

21 January 2018

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Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I).

21 January 2018

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Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I).

21 January 2018

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Substrate redox potential controls superoxide production kinetics in the cytochrome bc complex.

21 January 2018

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The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

21 January 2018

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The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

21 January 2018

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Reactions of the flavin mononucleotide in complex I: a combined mechanism describes NADH oxidation coupled to the reduction of APAD+, ferricyanide, or molecular oxygen

21 January 2018

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New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals

21 January 2018

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NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

21 January 2018

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

21 January 2018

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Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species

21 January 2018

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Does any yeast mitochondrial carrier have a native uncoupling protein function?

21 January 2018

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Identification and functions of new transporters in yeast mitochondria.

21 January 2018

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Wanderings in bioenergetics and biomembranes

21 January 2018

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Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria

21 January 2018

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Mitochondrial uncoupling proteins in unicellular eukaryotes

21 January 2018

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Uncoupling proteins: the issues from a biochemist point of view

21 January 2018

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Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.

21 January 2018

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Biochemical, physiological and medical aspects of ubiquinone function

21 January 2018

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Idebenone: a new antioxidant - Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants

21 January 2018

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Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

21 January 2018

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Effect of CoQ homologues on reactive oxygen generation by mitochondria

21 January 2018

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The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

21 January 2018

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Reduction of ubiquinone in membrane lipids by rat liver cytosol and its involvement in the cellular defence system against lipid peroxidation

21 January 2018

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Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

21 January 2018

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Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools

21 January 2018

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Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

21 January 2018

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Dual involvement of coenzyme Q10 in redox signaling and inhibition of death signaling in the rat heart mitochondria

21 January 2018

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Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property.

21 January 2018

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Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site

21 January 2018

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Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death

21 January 2018

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Coenzyme Q10 protects SHSY5Y neuronal cells from beta amyloid toxicity and oxygen-glucose deprivation by inhibiting the opening of the mitochondrial permeability transition pore

21 January 2018

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Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity

21 January 2018

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Coenzyme Q10 and lipid-related gene induction in HeLa cells.

21 January 2018

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Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells

21 January 2018

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Effects of ubiquinol-10 on microRNA-146a expression in vitro and in vivo

21 January 2018

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Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice.

21 January 2018

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Activation of NF-kappa B by reactive oxygen intermediates in the nervous system

21 January 2018

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Identification of LPS-inducible genes downregulated by ubiquinone in human THP-1 monocytes

21 January 2018

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Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

21 January 2018

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Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.

21 January 2018

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New insights into structure and function of mitochondria and their role in aging and disease

21 January 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state.

21 January 2018

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Mitochondrial-nuclear communications

21 January 2018

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How lipids affect the activities of integral membrane proteins

21 January 2018

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Lipid requirements for cytochrome c oxidase activity

21 January 2018

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Nuclear magnetic resonance investigation of the cytochrome oxidase-phospholipid interaction: a new model for boundary lipid

21 January 2018

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Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure

21 January 2018

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Cardiolipin stabilizes respiratory chain supercomplexes

21 January 2018

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Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane

21 January 2018

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Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome

21 January 2018

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Barth syndrome may be due to an acyltransferase deficiency

21 January 2018

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Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients

21 January 2018

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The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome

21 January 2018

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Mitochondrial defects lie at the basis of neutropenia in Barth syndrome

21 January 2018

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Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage

21 January 2018

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Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

21 January 2018

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Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

21 January 2018

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Structural and functional organization of Complex I in the mitochondrial respiratory chain

21 January 2018

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Energy metabolism of human neutrophils during phagocytosis

21 January 2018

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Significance of respirasomes for the assembly/stability of human respiratory chain complex I.

21 January 2018

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Respiratory complex III is required to maintain complex I in mammalian mitochondria

21 January 2018

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Respiratory chain supercomplexes set the threshold for respiration defects in human mtDNA mutant cybrids

21 January 2018

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A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast

21 January 2018

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Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts

21 January 2018

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The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme

21 January 2018

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OXPHOS Supercomplexes: respiration and life-span control in the aging model Podospora anserina.

21 January 2018

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Living forever and dying in the attempt

21 January 2018

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

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Mitochondrial DNA and ageing

21 January 2018

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Mitochondrial dysfunction as a cause of ageing

21 January 2018

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Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging

21 January 2018

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Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart.

21 January 2018

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Defining the transcriptomic and proteomic profiles of rat ageing skeletal muscle by the use of a cDNA array, 2D- and Blue native-PAGE approach.

21 January 2018

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Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex

21 January 2018

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Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria

21 January 2018

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Mitochondria in heart failure

21 January 2018

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Lipids in the assembly of membrane proteins and organization of protein supercomplexes: implications for lipid-linked disorders

21 January 2018

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The DNA sequence of human chromosome 21

21 January 2018

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Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells.

21 January 2018

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The role of oxidative stress in carcinogenesis

21 January 2018

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Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

21 January 2018

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Mitochondrial activities of a cell line derived from thyroid Hürthle cell tumors

21 January 2018

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Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

21 January 2018

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Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations.

21 January 2018

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Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency

21 January 2018

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Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

21 January 2018

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

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Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment

21 January 2018

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Mitochondrial therapies for Parkinson's disease

21 January 2018

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Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease

21 January 2018

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Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up

21 January 2018

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Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats

21 January 2018

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Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone).

21 January 2018

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A high diffusion coefficient for coenzyme Q10 might be related to a folded structure

21 January 2018

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The Interaction of Q Analogs, Particularly Hydroxydecyl Benzoquinone (Idebenone), with the Respiratory Complexes of Heart Mitochondria

21 January 2018

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Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

21 January 2018

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Exploring the Ubiquinone Binding Cavity of Respiratory Complex I

21 January 2018

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Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica

21 January 2018

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A Method for the Localization of Sites for Oxidative Phosphorylation

21 January 2018

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Coenzyme Q is an obligatory cofactor for uncoupling protein function

21 January 2018

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EPR, ENDOR and TRIPLE resonance and MO studies on ubiquinones (Q-n): comparison of radical anions and cations of coenzymes Q-10 and Q-6 with the model compounds Q-2 and Q-0

21 January 2018

1 reference

31 May 2024

https://opencitations.net/index/api/v1/citations/10.3891/ACTA.CHEM.SCAND.51-0233

Identifiers

DOI

10.1002/BIOF.168

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25 August 2017

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