(Q37945495)

25 August 2017

Inflammatory bowel disease: is it a primary immunodeficiency? (English)

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inflammatory bowel diseases

25 August 2017

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2

Bodo Grimbacher

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25 August 2017

Erik Glocker

1

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25 August 2017

14 October 2011

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Cellular and Molecular Life Sciences

25 August 2017

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25 August 2017

69

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25 August 2017

1

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25 August 2017

41-48

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https://scigraph.springernature.com/pub.10.1007/s00018-011-0837-9

25 August 2017

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cites work

Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Inflammatory bowel disease: cause and immunobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Indeterminate colitis: a distinctive clinical pattern of inflammatory bowel disease in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Unravelling the pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Guidelines for the management of inflammatory bowel disease in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

New pathophysiological insights and modern treatment of IBD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Inflammatory bowel disease, past, present and future: lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Regulatory T cells reinforce intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Regulatory T cells in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The genetics and immunopathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The genetics of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IL23R haplotypes provide a large population attributable risk for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Genetic variation in DLG5 is associated with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Autoimmune manifestations of the Wiskott-Aldrich syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Innate immunity in inflammatory bowel disease: a disease hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Phagocyte dysfunction and inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Neutrophil dysfunction in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Defective acute inflammation in Crohn's disease: a clinical investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Revisiting Crohn's disease as a primary immunodeficiency of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Extra-intestinal manifestations of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-10 and the interleukin-10 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Macrophage deactivation by interleukin 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-10 suppression of myeloid cell activation--a continuing puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-10-deficient mice develop chronic enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Gastric inflammatory fibroid polyp manifesting massive bleeding and marked morphological changes for a short period

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Identification and functional characterization of a second chain of the interleukin-10 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Cytokine signaling modules in inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IL-22 increases the innate immunity of tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Cytokine-mediated regulation of antimicrobial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IL-28, IL-29 and their class II cytokine receptor IL-28R

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Control of regulatory T cell lineage commitment and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A two-step process for thymic regulatory T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

21 January 2018

FOXP3: of mice and men.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A potential screening tool for IPEX syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A remarkable depletion of both naïve CD4+ and CD8+ with high proportion of memory T cells in an IPEX infant with a FOXP3 mutation in the forkhead domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Is Crohn's disease due to defective immunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

The biochemical basis of the NADPH oxidase of phagocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

How neutrophils kill microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Invasive aspergillosis in chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Genetics and immunopathology of chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Gastrointestinal involvement in chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

WASP: a key immunological multitasker

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

A multiinstitutional survey of the Wiskott-Aldrich syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

IBD and IBD mimicking enterocolitis in children younger than 2 years of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Chronic inflammatory bowel disease as key manifestation of atypical ARTEMIS deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0837-9

Chronic granulomatous disease

21 January 2018

1 reference

12 December 2020

A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease

1 reference

12 December 2020

Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea.

1 reference

12 December 2020

The role of the intestinal microflora in experimental colitis

1 reference

12 December 2020

Colitis in chronic granulomatous disease

1 reference

12 December 2020

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

1 reference

12 December 2020

The Wiskott-Aldrich syndrome

1 reference

12 December 2020

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

1 reference

12 December 2020

10.1007/S00018-011-0837-9

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21997382