(Q37961445)

1 July 2019

title

Selective molecular recognition in amyloid growth and transmission and cross-species barriers (English)

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1 July 2019

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1

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PubMed publication ID

26 August 2017

2

Ruth Nussinov

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PubMed publication ID

22119878

26 August 2017

language of work or name

English

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publication date

19 November 2011

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1 July 2019

Journal of Molecular Biology

published in

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1 July 2019

volume

421

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1 July 2019

issue

2-3

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1 July 2019

page(s)

172-184

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1 July 2019

Folding funnels, binding funnels, and protein function

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Folding funnels and binding mechanisms

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Folding and binding cascades: dynamic landscapes and population shifts

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Structured disorder and conformational selection

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

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Extended disordered proteins: targeting function with less scaffold

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

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The sequence dependence of fiber organization. A comparative molecular dynamics study of the islet amyloid polypeptide segments 22-27 and 22-29.

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Molecular dynamics simulations of the unfolding of beta(2)-microglobulin and its variants

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Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

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Conformation-dependent antibodies target diseases of protein misfolding

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The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

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Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease

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A specific amyloid-beta protein assembly in the brain impairs memory

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Recent atomic models of amyloid fibril structure

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Application of a Theory of Enzyme Specificity to Protein Synthesis

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Simulations as analytical tools to understand protein aggregation and predict amyloid conformation

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Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.

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Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins

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Fibrillogenic oligomers of human cystatin C are formed by propagated domain swapping

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Prion recognition elements govern nucleation, strain specificity and species barriers

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Insights into prion strains and neurotoxicity

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Surface structure of amyloid-beta fibrils contributes to cytotoxicity

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The structural basis of yeast prion strain variants

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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

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A polymer physics perspective on driving forces and mechanisms for protein aggregation

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Highly promiscuous nature of prion polymerization.

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A general model of prion strains and their pathogenicity

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Dead-end street of protein folding: thermodynamic rationale of amyloid fibril formation

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A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

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Conformational stability of PrP amyloid fibrils controls their smallest possible fragment size

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Biophysical characterization of intrinsically disordered proteins

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A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

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The role of prefibrillar structures in the assembly of a peptide amyloid

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Protein aggregation: more than just fibrils

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Fibril fragmentation enhances amyloid cytotoxicity

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The role of dynamic conformational ensembles in biomolecular recognition

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How do transcription factors select specific binding sites in the genome?

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Nanofiber micelles from the self-assembly of block copolymers

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Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation

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Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

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Mechanisms of transcription factor selectivity

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12 December 2020

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates

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12 December 2020

Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?

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12 December 2020

Structural and dynamics characteristics of acylphosphatase from Sulfolobus solfataricus in the monomeric state and in the initial native-like aggregates

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12 December 2020

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

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12 December 2020

Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

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12 December 2020

Direct observation of nucleation and growth in amyloid self-assembly

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12 December 2020

Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape

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A new story about an old guy: is Alzheimer's disease infectious?

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12 December 2020

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

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12 December 2020

Nucleation of amyloid fibrils

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12 December 2020

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

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12 December 2020

Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

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12 December 2020

Amyloid fibril formation by human stefins: Structure, mechanism & putative functions.

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Enzyme dynamics point to stepwise conformational selection in catalysis

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12 December 2020

Polymorphic C-terminal β-Sheet Interactions Determine the Formation of Fibril or Amyloid β-derived Diffusible Ligand-like Globulomer for the Alzheimer Aβ42 Dodecamer

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Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease

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12 December 2020

Intermolecular alignment in β2-microglobulin amyloid fibrils

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12 December 2020

Kinetic intermediates of β(2)-microglobulin fibril elongation probed by pulse-labeling H/D exchange combined with NMR analysis

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12 December 2020

β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages

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12 December 2020

Probing the nucleus model for oligomer formation during insulin amyloid fibrillogenesis

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12 December 2020

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

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12 December 2020

Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions

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12 December 2020

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

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12 December 2020

Conformational Conversion during Amyloid Formation at Atomic Resolution

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12 December 2020

Molecular dynamics simulation of β2-microglobulin in denaturing and stabilizing conditions

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12 December 2020

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

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12 December 2020

Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils

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12 December 2020

Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain

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12 December 2020

Multiple-targeting and conformational selection in the estrogen receptor: computation and experiment

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12 December 2020

Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states

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12 December 2020

Variations in filament conformation dictate seeding barrier between three- and four-repeat tau

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12 December 2020

Mechanisms of amyloid fibril formation--focus on domain-swapping

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12 December 2020

Systematic examination of polymorphism in amyloid fibrils by molecular-dynamics simulation

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12 December 2020

Amyloid fibrillation kinetics: insight from atomistic nucleation theory.

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12 December 2020

Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands

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12 December 2020

Polymorphic structures of Alzheimer's β-amyloid globulomers.

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12 December 2020

A diversity of assembly mechanisms of a generic amyloid fold

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12 December 2020

Dynamic allostery: linkers are not merely flexible

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12 December 2020

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

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12 December 2020

Polymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptide

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12 December 2020

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

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12 December 2020

Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly

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12 December 2020

Protein states and proteinquakes

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12 December 2020

From Levinthal to pathways to funnels

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12 December 2020

Conformational disease

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12 December 2020

Ligand binding to proteins: the binding landscape model

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

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12 December 2020

10.1016/J.JMB.2011.11.023

Identifiers

DOI

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1 July 2019

PMC publication ID

6407624

1 reference

1 July 2019

PubMed publication ID

22119878

1 reference

1 July 2019