(Q37972069)

26 August 2017

title

p53, a pivotal effector of a functional cross-talk linking presenilins and Pen-2. (English)

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26 August 2017

F Checler

1

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26 August 2017

J Dunys

series ordinal

2

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26 August 2017

language of work or name

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23 December 2011

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Neurodegenerative Diseases

26 August 2017

published in

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26 August 2017

volume

10

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26 August 2017

issue

1-4

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26 August 2017

page(s)

52-55

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The beta-secretase, BACE: a prime drug target for Alzheimer's disease

26 August 2017

cites work

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Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

21 January 2018

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Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

21 January 2018

1 reference

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

21 January 2018

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A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage

21 January 2018

1 reference

In vitro reconstitution of gamma-secretase activity using yeast microsomes

21 January 2018

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Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity

21 January 2018

1 reference

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

21 January 2018

1 reference

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

21 January 2018

1 reference

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity

21 January 2018

1 reference

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

21 January 2018

1 reference

Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene

21 January 2018

1 reference

p53 is regulated by and regulates members of the gamma-secretase complex

21 January 2018

1 reference

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

1 reference

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

21 January 2018

1 reference

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

21 January 2018

1 reference

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

21 January 2018

1 reference

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

21 January 2018

1 reference

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

21 January 2018

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beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

21 January 2018

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Possible roles of amyloid intracellular domain of amyloid precursor protein

21 January 2018

1 reference

Neuronal life and death: an essential role for the p53 family

21 January 2018

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p53 in neuronal apoptosis

21 January 2018

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p53: 25 years of research and more questions to answer.

21 January 2018

1 reference

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

21 January 2018

1 reference

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

21 January 2018

1 reference

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

21 January 2018

1 reference

p53-Dependent transcriptional control of cellular prion by presenilins.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000332935

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26 August 2017

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