(Q40174843)

English

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity

scientific article published on 2 February 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

apoptotic process

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Frédéric Checler

7

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Cristine Alves da Costa

object named as

Cristine Alves Da Costa

6

0 references

Peter Henry St George-Hyslop

object named as

Peter St George-Hyslop

5

0 references

Toshitaka Kawarai

2

object named as

Toshitaka Kawarai

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Julie Dunys

1

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Jean Sevalle

3

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Virginia Dolcini

4

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

language of work or name

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publication date

2 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

18 September 2017

282

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

14

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

10516-10525

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

Alzheimer's disease: genotypes, phenotypes, and treatments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Apoptosis in Alzheimer's disease--an update

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Neuroscience. New leads on the 'how' of Alzheimer's.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Macromolecular substrates for the ICE-like proteases during apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

The p53 tumor suppressor: critical regulator of life & death in cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Expression of apoptosis related proteins in brains of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Activation of caspase-8 in the Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Changes of p53 in the brains of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611572200

21 January 2018

Identifiers

10.1074/JBC.M611572200

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

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