(Q37975244)

26 August 2017

Targeting embryonic signaling pathways in cancer therapy (English)

1 reference

26 August 2017

Pamela Jo Harris

1

1 reference

26 August 2017

Giovanna Speranza

series ordinal

2

1 reference

26 August 2017

Claudio Dansky Ullmann

series ordinal

3

1 reference

26 August 2017

language of work or name

English

0 references

publication date

12 January 2012

1 reference

Expert Opinion on Therapeutic Targets

26 August 2017

1 reference

26 August 2017

16

1 reference

26 August 2017

1

1 reference

26 August 2017

131-145

1 reference

Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Cancer stem cells and self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hit 'em where they live: targeting the cancer stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Controversies in cancer stem cells: targeting embryonic signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Cancer stem cells in human gastrointestinal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Identification and expansion of the tumorigenic lung cancer stem cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Primary tumor genotype is an important determinant in identification of lung cancer propagating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Common critical pathways in embryogenesis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Intersection of signal transduction pathways and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Wnt signaling: a common theme in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

The therapeutic promise of the cancer stem cell concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling: endocrine gland development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling pathway as a therapeutic target in various types of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

GLI transcription factors: mediators of oncogenic Hedgehog signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Developmental genes and cancer: role of patched in basal cell carcinoma of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Identification of an amplified, highly expressed gene in a human glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Notch signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Notch signaling: the core pathway and its posttranslational regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Targeting Notch to target cancer stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Notch in lung development and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

The many faces of Notch signaling in skin-derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Embryonic signaling in melanoma: potential for diagnosis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Therapeutic promise and challenges of targeting DLL4/NOTCH1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Notch signaling regulates tumor angiogenesis by diverse mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Wnt signalling in stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Axin and hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Epigenetic regulation of Wnt signaling pathway in urological cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Targeting the Wnt/β-catenin signaling pathway in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.645808

10.1517/14728222.2011.645808

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference