(Q37979306)

26 August 2017

title

Development of novel CXCR4-based therapeutics (English)

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26 August 2017

Amnon Peled

1

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26 August 2017

Ori Wald

series ordinal

2

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26 August 2017

Jan Burger

series ordinal

3

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26 August 2017

language of work or name

English

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publication date

28 January 2012

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Expert Opinion on Investigational Drugs

26 August 2017

published in

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26 August 2017

volume

21

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26 August 2017

issue

3

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26 August 2017

page(s)

341-353

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Lymphocyte homing and homeostasis

26 August 2017

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

21 January 2018

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

21 January 2018

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

21 January 2018

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

21 January 2018

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Guidance of primordial germ cell migration by the chemokine SDF-1.

21 January 2018

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21 January 2018

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The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival

21 January 2018

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The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

21 January 2018

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CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature

21 January 2018

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The role of stromal-derived factor-1--CXCR7 axis in development and cancer

21 January 2018

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Homeostatic chemokine receptors and organ-specific metastasis

21 January 2018

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

21 January 2018

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Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

21 January 2018

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beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

21 January 2018

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CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion

21 January 2018

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CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

21 January 2018

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

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Mammalian MAP kinase signalling cascades

21 January 2018

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21 January 2018

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Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4.

21 January 2018

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The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases

21 January 2018

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CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.

21 January 2018

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Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

21 January 2018

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Chemokines integrate JAK/STAT and G‐protein pathways during chemotaxis and calcium flux responses

21 January 2018

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B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4.

21 January 2018

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B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

21 January 2018

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21 January 2018

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Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

21 January 2018

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

G protein coupled receptor structure and activation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Antigenically distinct conformations of CXCR4.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Safe use of the CXCR4 inhibitor ALX40-4C in humans

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Mobilization as a preparative regimen for hematopoietic stem cell transplantation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The bicyclam AMD3100 story

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

21 January 2018

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

A new classification for HIV-1

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

21 January 2018

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4

21 January 2018

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Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation.

21 January 2018

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Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-Hodgkin's lymphoma or multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantatio

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

A novel CXCR4 antagonist derived from human SDF-1beta enhances angiogenesis in ischaemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Chemokines regulate the migration of neural progenitors to sites of neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Stem cells and chronic lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

CXCR4 is a major chemokine receptor on glioma cells and mediates their survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Identification of bronchioalveolar stem cells in normal lung and lung cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.656197

CXCR4 regulates growth of both primary and metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Stromal fibroblasts in cancer: a novel tumor-promoting cell type

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Plerixafor: AMD 3100, AMD3100, JM 3100, SDZ SID 791

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.656197

10.1517/13543784.2012.656197

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference