(Q37989135)

26 August 2017

title

The emerging role of linear ubiquitination in cell signaling (English)

1 reference

26 August 2017

main subject

protein ubiquitination

1 reference

Christoph H Emmerich

1

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26 August 2017

Anna C Schmukle

series ordinal

2

1 reference

26 August 2017

Henning Walczak

series ordinal

3

1 reference

26 August 2017

language of work or name

1 reference

20 December 2011

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26 August 2017

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26 August 2017

volume

4

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26 August 2017

issue

204

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26 August 2017

page(s)

re5

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TNF-R1 signaling: a beautiful pathway

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Shared principles in NF-kappaB signaling

21 January 2018

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If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation

21 January 2018

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Tumor necrosis factor signaling.

21 January 2018

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Signalling pathways of the TNF superfamily: a double-edged sword

21 January 2018

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The origins of protein phosphorylation

21 January 2018

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Back to the future with ubiquitin

21 January 2018

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Ubiquitin: Roles in protein modification and breakdown

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

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A field guide to ubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

U box proteins as a new family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Nonproteolytic functions of ubiquitin in cell signaling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Newly identified tumor-associated role of human Sharpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Loss-of-function of SHARPIN causes an osteopenic phenotype in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Heme induces ubiquitination and degradation of the transcription factor Bach1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Autoregulation of Parkin activity through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Recognition of the polyubiquitin proteolytic signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Substrate selection by the proteasome during degradation of protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TAB3, a new binding partner of the protein kinase TAK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Ubiquitin-binding domains - from structures to functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Structural Basis for Recognition of Diubiquitins by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Expansion and evolution of cell death programmes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Mechanism of hypoxia-induced NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Direct activation of protein kinases by unanchored polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002187

10.1126/SCISIGNAL.2002187

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference