(Q37948115)

25 August 2017

title

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer (English)

1 reference

25 August 2017

0 references

0 references

1 reference

innate immune response

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22017428

15 December 2024

1

Henning Walczak

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A22017428

15 December 2024

language of work or name

1 reference

1 November 2011

1 reference

25 August 2017

November 2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22017428

full work available at URL

15 December 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-065X.2011.01066.x

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-065X.2011.01066.x

15 December 2024

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

15 December 2024

published in

Immunological Reviews

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25 August 2017

volume

244

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25 August 2017

issue

1

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25 August 2017

page(s)

9-28

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TNFR1-induced activation of the classical NF-κB pathway

25 August 2017

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Death receptor signal transducers: nodes of coordination in immune signaling networks

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Back to the future with ubiquitin

21 January 2018

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Ubiquitin: Roles in protein modification and breakdown

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Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

21 January 2018

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21 January 2018

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

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Nonproteolytic functions of ubiquitin in cell signaling

21 January 2018

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A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

21 January 2018

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily

21 January 2018

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The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

21 January 2018

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

21 January 2018

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

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Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

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Journal club. A new ubiquitin chain, a new signal

21 January 2018

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Ubiquitin-binding domains - from structures to functions

21 January 2018

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Structural Basis for Recognition of Diubiquitins by NEMO

21 January 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

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Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

21 January 2018

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Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

21 January 2018

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The emerging complexity of protein ubiquitination

21 January 2018

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

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Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.

21 January 2018

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Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling

21 January 2018

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Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway

21 January 2018

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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

21 January 2018

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

21 January 2018

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Asymmetric recruitment of cIAPs by TRAF2

21 January 2018

1 reference

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Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

21 January 2018

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB

21 January 2018

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Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling

21 January 2018

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Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation

21 January 2018

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Regulation of death receptor signaling by the ubiquitin system

21 January 2018

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Ubiquitin in NF-kappaB signaling.

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Direct activation of protein kinases by unanchored polyubiquitin chains

21 January 2018

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Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

21 January 2018

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Parkin and relatives: the RBR family of ubiquitin ligases

21 January 2018

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

21 January 2018

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

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Expansion and evolution of cell death programmes

21 January 2018

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Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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RIP kinases at the crossroads of cell death and survival

21 January 2018

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Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

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Necroptosis: biochemical, physiological and pathological aspects

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Virus inhibition of RIP3-dependent necrosis

21 January 2018

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Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

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Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry

21 January 2018

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Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins

21 January 2018

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RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

21 January 2018

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

21 January 2018

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

21 January 2018

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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TAB3, a new binding partner of the protein kinase TAK1

21 January 2018

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Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

21 January 2018

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

21 January 2018

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Deubiquitinases in the regulation of NF-κB signaling

21 January 2018

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

21 January 2018

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Isolation and characterization of two novel A20-like proteins

21 January 2018

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The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD

21 January 2018

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Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

21 January 2018

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NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

21 January 2018

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

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Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Breaking the chains: structure and function of the deubiquitinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Inflammation 2010: new adventures of an old flame

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Ubiquitin chain cleavage: CYLD at work

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2011.01066.X

RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1.

21 January 2018

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Newly identified tumor-associated role of human Sharpin

21 January 2018

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Identification of the familial cylindromatosis tumour-suppressor gene

21 January 2018

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Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation

21 January 2018

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New Perspectives in TNF-R1-Induced NF-κB Signaling

21 January 2018

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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

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The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research

21 January 2018

9

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

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1 reference

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17

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

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18

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

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40

1 reference

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69

1 reference

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NF-kappaB activation: Nondegradative ubiquitination implicates NEMO

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82

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2011.01066.X

A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice

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1 reference

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141

1 reference

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Identifiers

1 reference

25 August 2017

1 reference