(Q37701767)

22 August 2017

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title

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question (English)

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22 August 2017

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Nele Festjens

2

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Peter Vandenabeele

object named as

Peter Vandenabeele

series ordinal

4

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author name string

Franky Van Herreweghe

series ordinal

1

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PubMed ID

20198502

22 August 2017

Wim Declercq

series ordinal

3

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22 August 2017

4 March 2010

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Cellular and Molecular Life Sciences

22 August 2017

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22 August 2017

67

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22 August 2017

10

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22 August 2017

1567-1579

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0283-0

22 August 2017

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Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation

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Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes

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Mitochondrial contact sites. Lipid composition and dynamics

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Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

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Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

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Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells

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12 December 2020

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

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12 December 2020

TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFalpha-induced apoptosis

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12 December 2020

Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

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12 December 2020

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

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12 December 2020

Regulatory mechanism and physiological role of cytosolic phospholipase A2

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12 December 2020

CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation

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12 December 2020

Control of infection by pyroptosis and autophagy: role of TLR and NLR.

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12 December 2020

Cardiolipin provides specificity for targeting of tBid to mitochondria

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12 December 2020

More than one way to die: apoptosis, necrosis and reactive oxygen damage

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12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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12 December 2020

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing

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12 December 2020

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

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12 December 2020

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

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12 December 2020

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

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12 December 2020

Sphingolipid signaling and redox regulation

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12 December 2020

Phospholipase A2 biochemistry

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12 December 2020

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

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12 December 2020

Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation

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12 December 2020

TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination

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12 December 2020

Death receptor signal transducers: nodes of coordination in immune signaling networks

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12 December 2020

Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I.

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

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12 December 2020

Structure of the apoptotic protease-activating factor 1 bound to ADP

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12 December 2020

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

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12 December 2020

The role of the NFkappaB signalling pathway in cancer

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12 December 2020

High glucose initiates calpain-induced necrosis before apoptosis in LLC-PK1 cells

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12 December 2020

Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.

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12 December 2020

Peroxidation of liposomal lipids

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12 December 2020

Interdimer processing mechanism of procaspase-8 activation.

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

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12 December 2020

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

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12 December 2020

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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12 December 2020

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

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12 December 2020

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

1 reference

12 December 2020

Substrate specificities and properties of human phospholipases A2 in a mixed vesicle model

1 reference

12 December 2020

Caspase activation: revisiting the induced proximity model

1 reference

12 December 2020

TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent

1 reference

12 December 2020

Mechanism of XIAP-mediated inhibition of caspase-9

1 reference

12 December 2020

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

1 reference

12 December 2020

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

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12 December 2020

The TNF and TNF receptor superfamilies: integrating mammalian biology

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12 December 2020

Tumour necrosis factor and cancer

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12 December 2020

The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans

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12 December 2020

A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo

1 reference

12 December 2020

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

1 reference

12 December 2020

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

1 reference

12 December 2020

Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.

1 reference

12 December 2020

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

1 reference

12 December 2020

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

1 reference

12 December 2020

The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown

1 reference

12 December 2020

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

1 reference

12 December 2020

mu-Calpain mediated cleavage of the Na+/Ca2+ exchanger in isolated mitochondria under A23187 induced Ca2+ stimulation

1 reference

12 December 2020

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

1 reference

12 December 2020

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

1 reference

12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

12 December 2020

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

1 reference

12 December 2020

Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency

1 reference

12 December 2020

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

1 reference

12 December 2020

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

12 December 2020

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

1 reference

12 December 2020

Caspase inhibitors: viral, cellular and chemical

1 reference

12 December 2020

Molecular mechanisms and pathophysiology of necrotic cell death

1 reference

12 December 2020

Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion

1 reference

12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

1 reference

12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

1 reference

12 December 2020

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

1 reference

12 December 2020

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

1 reference

12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

1 reference

12 December 2020

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

1 reference

12 December 2020

NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling

1 reference

12 December 2020

Bax activation and mitochondrial insertion during apoptosis

1 reference

12 December 2020

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

1 reference

12 December 2020

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

1 reference

12 December 2020

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

1 reference

12 December 2020

Mechanistic insight into taxol-induced cell death

1 reference

12 December 2020

RIP1, a kinase on the crossroads of a cell's decision to live or die

1 reference

12 December 2020

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

1 reference

12 December 2020

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

1 reference

12 December 2020

Identification of RIP1 kinase as a specific cellular target of necrostatins

1 reference

12 December 2020

Effect of transient and permanent permeability transition pore opening on NAD(P)H localization in intact cells.

1 reference

12 December 2020

Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells

1 reference

12 December 2020

Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells

1 reference

12 December 2020

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 reference

12 December 2020

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

1 reference

12 December 2020

FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

1 reference

12 December 2020

The signaling adaptors and pathways activated by TNF superfamily

1 reference

12 December 2020

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

1 reference

12 December 2020

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

1 reference

12 December 2020

The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis.

1 reference

12 December 2020

TNF-alpha induces two distinct caspase-8 activation pathways

1 reference

12 December 2020

The TRAIL apoptotic pathway in cancer onset, progression and therapy

1 reference

12 December 2020

IAPs: what's in a name?

1 reference

12 December 2020

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

1 reference

12 December 2020

TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme

1 reference

12 December 2020

The morphology of various types of cell death in prenatal tissues

1 reference

12 December 2020

Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death

1 reference

12 December 2020

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

1 reference

12 December 2020

Glycolysis and perinatal hypoxic-ischemic brain damage

1 reference

12 December 2020

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

1 reference

12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

12 December 2020

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

1 reference

12 December 2020

Assessment of glycogen turnover in aerobic, ischemic, and reperfused working rat hearts

1 reference

12 December 2020

Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.

1 reference

12 December 2020

Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling

1 reference

12 December 2020

Lysosomal membrane permeabilization in cell death

1 reference

12 December 2020

Mitochondrial control of caspase-dependent and -independent cell death

1 reference

12 December 2020

The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells

1 reference

12 December 2020

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

1 reference

12 December 2020

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury.

1 reference

12 December 2020

Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells

1 reference

12 December 2020

Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.

1 reference

12 December 2020

Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

1 reference

12 December 2020

Regulation of autophagy in mammals and its interplay with apoptosis.

1 reference

12 December 2020

The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore

1 reference

12 December 2020

Shrinkage necrosis: a distinct mode of cellular death.

1 reference

12 December 2020

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

1 reference

12 December 2020

RIP kinases at the crossroads of cell death and survival

1 reference

12 December 2020

Mitochondrial metabolism of reactive oxygen species.

1 reference

12 December 2020

The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release

1 reference

12 December 2020

The apoptosome: signalling platform of cell death

1 reference

12 December 2020

Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL.

1 reference

12 December 2020

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

1 reference

12 December 2020

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

1 reference

12 December 2020

Structural Basis of Caspase Inhibition by XIAP

1 reference

12 December 2020

10.1007/S00018-010-0283-0

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20198502