(Q37994260)

26 August 2017

Cell-based in vitro models for predicting drug permeability (English)

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26 August 2017

1

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26 August 2017

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26 August 2017

5

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26 August 2017

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PubMed ID

22424145

26 August 2017

Sara Baptista da Silva

object named as

Sara Baptista da Silva

series ordinal

3

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Francisca Rodrigues

object named as

Francisca Rodrigues

series ordinal

4

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language of work or name

English

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publication date

18 March 2012

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Expert Opinion on Drug Metabolism & Toxicology

26 August 2017

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26 August 2017

8

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26 August 2017

607-621

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26 August 2017

5

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In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

In vitro-in vivo correlation: perspectives on model development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Current methodologies used for evaluation of intestinal permeability and absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Predicting oral drug absorption and hepatobiliary clearance: Human intestinal and hepatic in vitro cell models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Recent advances and novel strategies in pre-clinical formulation development: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Coexistence of passive and carrier-mediated processes in drug transport

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Strategies for absorption screening in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Caco-2 monolayers in experimental and theoretical predictions of drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Short term Caco-2/TC7 cell culture: comparison between conventional 21-d and a commercially available 3-d system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Resistance to high concentrations of methotrexate and 5-fluorouracil of differentiated HT-29 colon-cancer cells is restricted to cells of enterocytic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: comparison of active and passive transport with the human colon carcinoma Caco-2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Comparison of Caco-2, IEC-18 and HCEC cell lines as a model for intestinal absorption of genistein, daidzein and their glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Reciprocal regulation of the primary sodium absorptive pathways in rat intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

The Madin Darby canine kidney (MDCK) epithelial cell monolayer as a model cellular transport barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Development of a triculture based system for improved benefit/risk assessment in pharmacology and human food

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Development of a rectal nicotine delivery system for the treatment of ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Cultured human ectocervical epithelial cell differentiation is regulated by the combined direct actions of sex steroids, glucocorticoids, and retinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Vaginal-cervical epithelial permeability decreases after menopause

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Aging and estrogen effects on transcervical-transvaginal epithelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Regulation of the paracellular permeability of cultured human cervical epithelium by a nucleotide receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Delivery of TEM beta-lactamase by gene-transformed Lactococcus lactis subsp. lactis through cervical cell monolayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Development of an in vitro alternative assay method for vaginal irritation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Hydrogen peroxide mediated transvaginal drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Preclinical evaluation of UC781 microbicide vaginal drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

The human bronchial epithelial cell line 16HBE14o- as a model system of the airways for studying drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Human respiratory epithelial cell culture for drug delivery applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

The use of human nasal in vitro cell systems during drug discovery and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

A three-dimensional cellular model of the human respiratory tract to study the interaction with particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Primary human coculture model of alveolo-capillary unit to study mechanisms of injury to peripheral lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Comparison of human tracheal/bronchial epithelial cell culture and bovine nasal respiratory explants for nasal drug transport studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Differential expression of organic cation transporters in normal and polyps human nasal epithelium: implications for in vitro drug delivery studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Nasal absorption enhancement strategies for therapeutic peptides: an in vitro study using cultured human nasal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Cytokine responses by conjunctival epithelial cells: an in vitro model of ocular inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Development of immortalized rat conjunctival epithelial cell lines: an in vitro model to examine transepithelial antigen delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Retinal synthesis and deposition of complement components induced by ocular hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Cell culture models of the ocular barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Chitosan-based nanostructures: a delivery platform for ocular therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Bacterial Ghosts as antigen and drug delivery system for ocular surface diseases: Effective internalization of Bacterial Ghosts by human conjunctival epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

A biodegradable injectable implant sustains systemic and ocular delivery of an aldose reductase inhibitor and ameliorates biochemical changes in a galactose-fed rat model for diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Development of genotoxicity test procedures with Episkin, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: application of the EpiDerm human reconstructed epidermis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Analysis of in vitro release through reconstructed human epidermis and synthetic membranes of multi-vitamins from cosmetic formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Cell culture-based models for intestinal permeability: a critique

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Facilitated nanoscale delivery of insulin across intestinal membrane models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

Antioxidants in the Prevention and Treatment of Diabetic Retinopathy – A Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.673586

10.1517/17425255.2012.673586

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22424145