(Q37997735)

26 August 2017

Effector functions of NLRs in the intestine: innate sensing, cell death, and disease (English)

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26 August 2017

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Garabet Yeretssian

1

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PubMed ID

22454103

26 August 2017

language of work or name

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1 December 2012

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26 August 2017

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26 August 2017

54

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26 August 2017

1-3

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26 August 2017

25-36

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https://scigraph.springernature.com/pub.10.1007/s12026-012-8317-3

26 August 2017

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cites work

Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells

1 reference

12 December 2020

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation

1 reference

12 December 2020

Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions

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12 December 2020

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

1 reference

12 December 2020

Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity

1 reference

12 December 2020

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen

1 reference

12 December 2020

Inflammasome recognition of influenza virus is essential for adaptive immune responses

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12 December 2020

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

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12 December 2020

A role for mitochondria in NLRP3 inflammasome activation

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12 December 2020

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

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12 December 2020

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production

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12 December 2020

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

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12 December 2020

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

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12 December 2020

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

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12 December 2020

Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling.

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12 December 2020

A Shope Fibroma virus PYRIN-only protein modulates the host immune response

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12 December 2020

Molecular regulation of inflammation and cell death

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12 December 2020

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

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12 December 2020

Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity

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12 December 2020

Nod1 Participates in the Innate Immune Response toPseudomonas aeruginosa

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12 December 2020

Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains

1 reference

12 December 2020

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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12 December 2020

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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12 December 2020

NLRX1 is a regulator of mitochondrial antiviral immunity

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12 December 2020

At the gates of death.

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12 December 2020

The Nalp3 inflammasome is essential for the development of silicosis

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12 December 2020

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

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12 December 2020

Interactions between commensal intestinal bacteria and the immune system

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12 December 2020

A microbial symbiosis factor prevents intestinal inflammatory disease

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12 December 2020

Homeostasis and inflammation in the intestine

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12 December 2020

COPs and POPs: modulators of inflammasome activity

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12 December 2020

NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK

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12 December 2020

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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12 December 2020

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

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12 December 2020

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

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12 December 2020

Intestinal epithelial stem cells and progenitors

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12 December 2020

War and peace at mucosal surfaces

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12 December 2020

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

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12 December 2020

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

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12 December 2020

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

1 reference

12 December 2020

A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways

1 reference

12 December 2020

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

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12 December 2020

Influenza virus activates inflammasomes via its intracellular M2 ion channel

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12 December 2020

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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12 December 2020

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

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12 December 2020

Apoptosis in the development of the immune system

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12 December 2020

PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages

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12 December 2020

Gout-associated uric acid crystals activate the NALP3 inflammasome

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12 December 2020

XIAP mediates NOD signaling via interaction with RIP2

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12 December 2020

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

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12 December 2020

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

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12 December 2020

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

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12 December 2020

The microbial and danger signals that activate Nod-like receptors

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12 December 2020

The PYRIN domain: a member of the death domain-fold superfamily

1 reference

12 December 2020

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

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12 December 2020

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

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12 December 2020

Innate immune mechanisms of colitis and colitis-associated colorectal cancer

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12 December 2020

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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12 December 2020

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

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12 December 2020

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

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12 December 2020

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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12 December 2020

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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12 December 2020

NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways

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12 December 2020

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

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12 December 2020

The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock

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12 December 2020

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.

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12 December 2020

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

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12 December 2020

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

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12 December 2020

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12 December 2020

NALP1 in vitiligo-associated multiple autoimmune disease

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12 December 2020

Induction of intestinal Th17 cells by segmented filamentous bacteria

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12 December 2020

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

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12 December 2020

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans

1 reference

12 December 2020

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

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12 December 2020

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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12 December 2020

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12 December 2020

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

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12 December 2020

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

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12 December 2020

Lysosomal destabilization in p53-induced apoptosis

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12 December 2020

Induction of colonic regulatory T cells by indigenous Clostridium species

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12 December 2020

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization

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12 December 2020

The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes

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12 December 2020

Gastrointestinal microbiology enters the metagenomics era.

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12 December 2020

ICEBERG: a novel inhibitor of interleukin-1beta generation

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12 December 2020

Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

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12 December 2020

Immune development in jejunal mucosa after colonization with selected commensal gut bacteria: a study in germ-free pigs.

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12 December 2020

Human caspase 12 has acquired deleterious mutations

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12 December 2020

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

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12 December 2020

NOD-like receptors: role in innate immunity and inflammatory disease

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12 December 2020

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

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12 December 2020

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

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12 December 2020

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

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12 December 2020

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

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12 December 2020

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.

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12 December 2020

Microbial control of regulatory and effector T cell responses in the gut.

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12 December 2020

Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes

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12 December 2020

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

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12 December 2020

The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection

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12 December 2020

Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis

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12 December 2020

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

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12 December 2020

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

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12 December 2020

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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12 December 2020

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

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12 December 2020

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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12 December 2020

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis

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12 December 2020

Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome

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12 December 2020

Before they were gut dendritic cells

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12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

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12 December 2020

Cryopyrin activates the inflammasome in response to toxins and ATP

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12 December 2020

Regulation of apoptosis by the redox state of cytochrome c.

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12 December 2020

The inflammasomes: guardians of the body

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12 December 2020

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

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12 December 2020

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

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12 December 2020

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

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12 December 2020

Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity

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12 December 2020

The inflammasome: a danger sensing complex triggering innate immunity

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12 December 2020

Plant disease resistance protein signaling: NBS-LRR proteins and their partners

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12 December 2020

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

1 reference

12 December 2020

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

1 reference

12 December 2020

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

1 reference

12 December 2020

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

1 reference

12 December 2020

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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12 December 2020

Dampening inflammation

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12 December 2020

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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12 December 2020

Nod2 is essential for temporal development of intestinal microbial communities.

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12 December 2020

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

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12 December 2020

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

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12 December 2020

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

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12 December 2020

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

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12 December 2020

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal -Glucan

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12 December 2020

NLRC5 limits the activation of inflammatory pathways

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12 December 2020

Integrating cell-signalling pathways with NF-kappaB and IKK function

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12 December 2020

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

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12 December 2020

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

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12 December 2020

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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12 December 2020

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

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12 December 2020

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

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12 December 2020

Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.

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12 December 2020

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

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12 December 2020

NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila

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12 December 2020

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

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12 December 2020

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

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12 December 2020

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

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12 December 2020

Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells

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12 December 2020

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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12 December 2020

The NLR gene family: a standard nomenclature

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12 December 2020

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

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12 December 2020

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

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12 December 2020

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

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12 December 2020

Self-nonself discrimination, histoincompatibility, and the concept of immunology

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12 December 2020

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

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12 December 2020

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system

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12 December 2020

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

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12 December 2020

Inflammatory bowel disease

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12 December 2020

Lysosomal membrane permeabilization in cell death

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12 December 2020

Nod2 is required for the regulation of commensal microbiota in the intestine

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12 December 2020

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

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12 December 2020

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

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12 December 2020

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

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12 December 2020

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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12 December 2020

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

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12 December 2020

Pseudomonas aeruginosa activates caspase 1 through Ipaf

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12 December 2020

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

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12 December 2020

Spread of an inactive form of caspase-12 in humans is due to recent positive selection

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12 December 2020

The apoptosome: signalling platform of cell death

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12 December 2020

Non-apoptotic role of BID in inflammation and innate immunity.

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12 December 2020

10.1007/S12026-012-8317-3

Identifiers

DOI

1 reference

release_hjemxcdtpffetbyzkflf6sdnmu

26 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hjemxcdtpffetbyzkflf6sdnmu

24 November 2022

mapped directly with Wikidata item

PubMed ID

22454103

1 reference

PubMed ID

22454103