(Q37998312)

26 August 2017

0 references

Novel molecular targets for atrial fibrillation therapy (English)

1 reference

26 August 2017

0 references

3

Stanley Nattel

1 reference

26 August 2017

1

Dobromir Dobrev

1 reference

26 August 2017

Leif Carlsson

2

1 reference

26 August 2017

30 March 2012

1 reference

Nature Reviews Drug Discovery

26 August 2017

1 reference

26 August 2017

11

1 reference

26 August 2017

4

1 reference

26 August 2017

275-291

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd3682

26 August 2017

0 references

cites work

Atrial fibrillation: strategies to control, combat, and cure

1 reference

Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop

21 January 2018

1 reference

New antiarrhythmic drugs for treatment of atrial fibrillation.

21 January 2018

1 reference

Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial

21 January 2018

1 reference

Atrial fibrillation and the expanding role of catheter ablation: do antiarrhythmic drugs have a future?

21 January 2018

1 reference

Long-term single- and multiple-procedure outcome and predictors of success after catheter ablation for persistent atrial fibrillation.

21 January 2018

1 reference

Dronedarone in High-Risk Permanent Atrial Fibrillation

21 January 2018

1 reference

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

21 January 2018

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Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

21 January 2018

1 reference

Controversies in atrial fibrillation

21 January 2018

1 reference

Atrial fibrillation pathophysiology: implications for management.

21 January 2018

1 reference

An epidemic of atrial fibrillation?

21 January 2018

1 reference

Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.

21 January 2018

1 reference

Recent advances in the molecular pathophysiology of atrial fibrillation.

21 January 2018

1 reference

Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure

21 January 2018

1 reference

Electrical remodeling in atrial fibrillation

21 January 2018

1 reference

Atrial remodeling and atrial fibrillation: mechanisms and implications.

21 January 2018

1 reference

Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides

21 January 2018

1 reference

Electrical, contractile and structural remodeling during atrial fibrillation

21 January 2018

1 reference

Consequences of atrial electrical remodeling for the anti-arrhythmic action of class IC and class III drugs

21 January 2018

1 reference

Does flecainide regain its antiarrhythmic activity after electrical cardioversion of persistent atrial fibrillation?

21 January 2018

1 reference

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications

21 January 2018

1 reference

Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone

21 January 2018

1 reference

Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis?

21 January 2018

1 reference

Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation

21 January 2018

1 reference

Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation

21 January 2018

1 reference

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation

21 January 2018

1 reference

L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases

21 January 2018

1 reference

Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

21 January 2018

1 reference

Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action poten

21 January 2018

1 reference

Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes

21 January 2018

1 reference

In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both

21 January 2018

1 reference

Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current

21 January 2018

1 reference

MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation

21 January 2018

1 reference

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

21 January 2018

1 reference

Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels

21 January 2018

1 reference

Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation

21 January 2018

1 reference

The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation

21 January 2018

1 reference

Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

21 January 2018

1 reference

Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation

21 January 2018

1 reference

Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation

21 January 2018

1 reference

Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling.

21 January 2018

1 reference

Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study

21 January 2018

1 reference

The role of connexin40 in atrial fibrillation

21 January 2018

1 reference

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.

21 January 2018

1 reference

Defective cardiac ryanodine receptor regulation during atrial fibrillation

21 January 2018

1 reference

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation

21 January 2018

1 reference

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis

21 January 2018

1 reference

Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

21 January 2018

1 reference

Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation

21 January 2018

1 reference

Type 1 phosphatase, a negative regulator of cardiac function

21 January 2018

1 reference

Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy

21 January 2018

1 reference

Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness

21 January 2018

1 reference

Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort

21 January 2018

1 reference

Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation

21 January 2018

1 reference

New ideas about atrial fibrillation 50 years on.

21 January 2018

1 reference

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.

21 January 2018

1 reference

Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs.

21 January 2018

1 reference

Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs

21 January 2018

1 reference

Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications

21 January 2018

1 reference

Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation

21 January 2018

1 reference

"Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat

21 January 2018

1 reference

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation

21 January 2018

1 reference

Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation

21 January 2018

1 reference

Effects of a highly selective acetylcholine-activated K+ channel blocker on experimental atrial fibrillation.

21 January 2018

1 reference

Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation

21 January 2018

1 reference

Animal models for atrial fibrillation: clinical insights and scientific opportunities.

21 January 2018

1 reference

Expression of connexins 40 and 43 in human left atrium in atrial fibrillation of different aetiologies

21 January 2018

1 reference

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

21 January 2018

1 reference

Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

21 January 2018

1 reference

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release

21 January 2018

1 reference

Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.

21 January 2018

1 reference

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

21 January 2018

1 reference

Calmodulin-kinases: modulators of neuronal development and plasticity

21 January 2018

1 reference

The gamma isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption

21 January 2018

1 reference

Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling

21 January 2018

1 reference

A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation

21 January 2018

1 reference

Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target

21 January 2018

1 reference

Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles.

21 January 2018

1 reference

Oxidized CaMKII causes cardiac sinus node dysfunction in mice.

21 January 2018

1 reference

Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling

21 January 2018

1 reference

Na+/Ca2+ exchange inhibitors: a new class of calcium regulators

21 January 2018

1 reference

Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target

21 January 2018

1 reference

Inward rectifier potassium currents as a target for atrial fibrillation therapy

21 January 2018

1 reference

Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel

21 January 2018

1 reference

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

21 January 2018

1 reference

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

21 January 2018

1 reference

Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine

21 January 2018

1 reference

Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

21 January 2018

1 reference

Short variable sequence acquired in evolution enables selective inhibition of various inward-rectifier K+ channels.

21 January 2018

1 reference

Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels

21 January 2018

1 reference

Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.

21 January 2018

1 reference

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.

21 January 2018

1 reference

Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way.

21 January 2018

1 reference

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences

21 January 2018

1 reference

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain

21 January 2018

1 reference

Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.

21 January 2018

1 reference

The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels

21 January 2018

1 reference

Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1.

21 January 2018

1 reference

Gastric ulcerogenic and biological activities of N-3'a-propyphenazonyl-2-acetoxybenzamide

21 January 2018

1 reference

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation

21 January 2018

1 reference

Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.

21 January 2018

1 reference

PH regulation of connexin43: molecular analysis of the gating particle

21 January 2018

1 reference

Identification of a novel peptide that interferes with the chemical regulation of connexin43.

21 January 2018

1 reference

RXP-E: a connexin43-binding peptide that prevents action potential propagation block

21 January 2018

1 reference

Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides

21 January 2018

1 reference

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

21 January 2018

1 reference

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

21 January 2018

1 reference

Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes.

21 January 2018

1 reference

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity

21 January 2018

1 reference

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.

21 January 2018

1 reference

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

21 January 2018

1 reference

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

21 January 2018

1 reference

Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.

21 January 2018

1 reference

Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation

21 January 2018

1 reference

Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation

21 January 2018

1 reference

1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus

21 January 2018

1 reference

Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation

21 January 2018

1 reference

Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor

21 January 2018

1 reference

Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes.

21 January 2018

1 reference

Ion channel trafficking: a new therapeutic horizon for atrial fibrillation

21 January 2018

1 reference

Internalized Kv1.5 traffics via Rab-dependent pathways

21 January 2018

1 reference

Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance

21 January 2018

1 reference

Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.

21 January 2018

1 reference

Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.

21 January 2018

1 reference

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation.

21 January 2018

1 reference

Atrial fibrosis and the mechanisms of atrial fibrillation

21 January 2018

1 reference

n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: a prospective, randomized study

21 January 2018

1 reference

TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation

21 January 2018

1 reference

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

21 January 2018

1 reference

miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling

21 January 2018

1 reference

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

1 reference

Micro-RNA in disease and gene therapy

21 January 2018

1 reference

Shielding the messenger (RNA): microRNA-based anticancer therapies

21 January 2018

1 reference

Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer

21 January 2018

1 reference

Biological therapies for atrial fibrillation

21 January 2018

1 reference

Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model

21 January 2018

1 reference

Common variants in KCNN3 are associated with lone atrial fibrillation

21 January 2018

1 reference

The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca(2+)-activated K(+) channels.

21 January 2018

1 reference

Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model

21 January 2018

1 reference

Structure-Based Virtual Screening and Electrophysiological Evaluation of New Chemotypes of Kv1.5 Channel Blockers

21 January 2018

1 reference

Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model

21 January 2018

1 reference

Clinical evaluation of a policy of early repeated internal cardioversion for recurrence of atrial fibrillation

31 March 2020

1 reference

Heterogeneous changes in electrophysiologic properties in the paroxysmal and chronically fibrillating human atrium

31 March 2020

1 reference

Cellular effects of beta-particle delivery on vascular smooth muscle cells and endothelial cells: a dose-response study

31 March 2020

1 reference

Atrial L-type Ca2+ currents and human atrial fibrillation

31 March 2020

1 reference

Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias

31 March 2020

1 reference

Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation

31 March 2020

1 reference

Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation

31 March 2020

1 reference

Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation

31 March 2020

1 reference

Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation

31 March 2020

1 reference

Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+channels

31 March 2020

1 reference

Structural correlate of atrial fibrillation in human patients

31 March 2020

1 reference

Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure

31 March 2020

1 reference

Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes

31 March 2020

1 reference

Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs

31 March 2020

1 reference

X-ROS signaling: rapid mechano-chemo transduction in heart

31 March 2020

1 reference

Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model

31 March 2020

1 reference

Dantrolene sodium improves the force-frequency relationship and beta-adregenic responsiveness in failing human myocardium

31 March 2020

1 reference

Polyunsaturated fatty acids for prevention of atrial fibrillation: a 'fishy' story

31 March 2020

1 reference

Primary and secondary prevention of atrial fibrillation with statins and polyunsaturated fatty acids: review of evidence and clinical relevance

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22460122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22460122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22460122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3682

1 reference

26 August 2017

1 reference

PubMed ID

22460122