(Q37999063)

26 August 2017

title

Structure-based drug discovery of carbonic anhydrase inhibitors (English)

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26 August 2017

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1

Claudiu T Supuran

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26 August 2017

publication date

2 April 2012

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Journal of Enzyme Inhibition and Medicinal Chemistry

26 August 2017

published in

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26 August 2017

volume

27

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26 August 2017

issue

6

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26 August 2017

page(s)

759-772

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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

26 August 2017

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Structure and function of carbonic anhydrases from Mycobacterium tuberculosis

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Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis

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Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine

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Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

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Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.

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Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

21 January 2018

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Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

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Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

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Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

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Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

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Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

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Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

21 January 2018

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Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib

21 January 2018

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Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.

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Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

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Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

21 January 2018

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Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells

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Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes

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Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

21 January 2018

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Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

21 January 2018

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Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

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In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

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Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

21 January 2018

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Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

21 January 2018

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The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents

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Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

21 January 2018

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Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

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Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies

21 January 2018

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Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

21 January 2018

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Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

21 January 2018

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Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

21 January 2018

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Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV

21 January 2018

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Characterization and inhibition studies of an α-carbonic anhydrase from the endangered sturgeon species Acipenser gueldenstaedti.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Brucella carbonic anhydrases: new targets for designing anti-infective agents

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Crystal structure of E. coli β-carbonic anhydrase, an enzyme with an unusual pH-dependent activity

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic Anhydrase Inhibitors: X-ray and Molecular Modeling Study for the Interaction of a Fluorescent Antitumor Sulfonamide with Isozyme II and IX

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2012.672983

10.3109/14756366.2012.672983

21 January 2018

Identifiers

DOI

1 reference

release_rh7depr6ojb75b3qz24oxvx66y

26 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/rh7depr6ojb75b3qz24oxvx66y

mapped directly with Wikidata item

24 November 2022

based on heuristic

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