(Q38003542)

26 August 2017

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Protein tyrosine phosphatases in lymphocyte activation and autoimmunity (English)

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26 August 2017

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2

André Veillette

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26 August 2017

Inmoo Rhee

1

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26 August 2017

language of work or name

English

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publication date

18 April 2012

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26 August 2017

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26 August 2017

volume

13

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26 August 2017

issue

5

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26 August 2017

page(s)

439-447

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Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase

26 August 2017

cites work

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12 December 2020

SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells

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12 December 2020

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

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12 December 2020

TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses

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12 December 2020

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

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12 December 2020

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

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12 December 2020

Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant

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12 December 2020

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor

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12 December 2020

PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients

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12 December 2020

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

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12 December 2020

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

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12 December 2020

CD45: a critical regulator of signaling thresholds in immune cells

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12 December 2020

The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation

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12 December 2020

In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation

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12 December 2020

Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development

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12 December 2020

The Phosphatase PTP-PEST Promotes Secondary T Cell Responses by Dephosphorylating the Protein Tyrosine Kinase Pyk2

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12 December 2020

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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12 December 2020

The kinetic-segregation model: TCR triggering and beyond

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12 December 2020

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli

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12 December 2020

Protein tyrosine phosphatases and the immune response

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12 December 2020

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

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12 December 2020

Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation

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12 December 2020

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

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12 December 2020

A point mutation in PTPRC is associated with the development of multiple sclerosis

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12 December 2020

Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.

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12 December 2020

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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12 December 2020

Nonreceptor protein-tyrosine phosphatases in immune cell signaling

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12 December 2020

Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production

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12 December 2020

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

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12 December 2020

Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

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12 December 2020

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

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12 December 2020

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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12 December 2020

A novel, specific interaction involving the Csk SH3 domain and its natural ligand

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12 December 2020

Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP

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12 December 2020

A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease

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12 December 2020

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

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12 December 2020

Roles of the NKG2D immunoreceptor and its ligands

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12 December 2020

Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148

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12 December 2020

Protein tyrosine phosphatases in autoimmunity.

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12 December 2020

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

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12 December 2020

B cells acquire antigen from target cells after synapse formation

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12 December 2020

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

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12 December 2020

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

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12 December 2020

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes

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12 December 2020

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population

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12 December 2020

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

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12 December 2020

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

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12 December 2020

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

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12 December 2020

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

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12 December 2020

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

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12 December 2020

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

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12 December 2020

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

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12 December 2020

Transmembrane adaptor proteins: organizers of immunoreceptor signalling

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12 December 2020

Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

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12 December 2020

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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12 December 2020

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

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12 December 2020

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes

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12 December 2020

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

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12 December 2020

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

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12 December 2020

Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk)

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12 December 2020

PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

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12 December 2020

Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice

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12 December 2020

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

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12 December 2020

Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism

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12 December 2020

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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12 December 2020

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

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12 December 2020

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice

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12 December 2020

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

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12 December 2020

Protein tyrosine phosphatase PTPN22 in human autoimmunity

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12 December 2020

Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future

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12 December 2020

Negative regulation of immunoreceptor signaling

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12 December 2020

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

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12 December 2020

The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1

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12 December 2020

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12 December 2020

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

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12 December 2020

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

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12 December 2020

The src homology 2 domain-containing tyrosine phosphatase 2 regulates primary T-dependent immune responses and Th cell differentiation

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12 December 2020

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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12 December 2020

SLAM-family receptors: immune regulators with or without SAP-family adaptors

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12 December 2020

Adaptors as central mediators of signal transduction in immune cells

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12 December 2020

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

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12 December 2020

Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.

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12 December 2020

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

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12 December 2020

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

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12 December 2020

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

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12 December 2020

PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders

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12 December 2020

Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

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12 December 2020

A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

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12 December 2020

CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells

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12 December 2020

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival

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12 December 2020

JAK-STAT signaling: from interferons to cytokines

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12 December 2020

Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45

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12 December 2020

Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice

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12 December 2020

Alternative splicing of CD45: the tip of the iceberg.

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12 December 2020

Identifiers

DOI

10.1038/NI.2246

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26 August 2017

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