(Q35852278)

10 August 2017

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title

Transmembrane adaptor proteins: organizers of immunoreceptor signalling (English)

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10 August 2017

transmembrane protein

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1

Václav Horejsí

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10 August 2017

Weiguo Zhang

2

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PubMed ID

15286727

10 August 2017

Burkhart Schraven

series ordinal

3

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10 August 2017

1 August 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

8

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10 August 2017

603-616

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Antigen receptor tail clue.

10 August 2017

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New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)

21 January 2018

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Floating the raft hypothesis: lipid rafts play a role in immune cell activation

21 January 2018

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The roles of membrane microdomains (rafts) in T cell activation

21 January 2018

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

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Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells

21 January 2018

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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

21 January 2018

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

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Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

21 January 2018

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LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids

21 January 2018

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Essential role of LAT in T cell development

21 January 2018

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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

21 January 2018

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

21 January 2018

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Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

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Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

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Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

21 January 2018

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Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

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Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

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Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

21 January 2018

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RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

21 January 2018

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A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

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Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

21 January 2018

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LAT regulates gammadelta T cell homeostasis and differentiation

21 January 2018

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Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

21 January 2018

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Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells

21 January 2018

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Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with phosphatidylinositol 3-kinase and phospholipase C-gamma following CD2 stimulation

21 January 2018

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2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function

21 January 2018

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2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways

21 January 2018

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Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3.

21 January 2018

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The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking

21 January 2018

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Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin

21 January 2018

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LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

21 January 2018

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Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling

21 January 2018

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An essential role for BLNK in human B cell development

21 January 2018

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Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

21 January 2018

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Appearance of the LAT protein at an early stage of B-cell development and its possible role

21 January 2018

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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

21 January 2018

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LAB: a new membrane-associated adaptor molecule in B cell activation

21 January 2018

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The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB

21 January 2018

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Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding

21 January 2018

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Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

21 January 2018

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The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

21 January 2018

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NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation

21 January 2018

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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

21 January 2018

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

21 January 2018

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Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

21 January 2018

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Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor

21 January 2018

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Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts

21 January 2018

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

21 January 2018

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Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk

21 January 2018

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Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling

21 January 2018

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Cutting Edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI

21 January 2018

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Differential effects of filipin and methyl-beta-cyclodextrin on B cell receptor signaling

21 January 2018

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Regulation of the phospholipase C-gamma2 pathway in B cells

21 January 2018

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Regulation of B cell fates by BCR signaling components

21 January 2018

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Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes

21 January 2018

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Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton

21 January 2018

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Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts

21 January 2018

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LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling

21 January 2018

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LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation

21 January 2018

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Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts

21 January 2018

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Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta

21 January 2018

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Lipid rafts: resolution of the "fyn problem"?

21 January 2018

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Perturbation of the T4 molecule transmits a negative signal to T cells

21 January 2018

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A therapeutic CD4 monoclonal antibody inhibits TCR-zeta chain phosphorylation, zeta-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells

21 January 2018

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Antibody-induced transplantation tolerance: the role of dominant regulation

21 January 2018

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Molecular events associated with CD4-mediated Down-regulation of LFA-1-dependent adhesion

21 January 2018

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The activation of Csk by CD4 interferes with TCR-mediated activatory signaling

21 January 2018

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SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation

21 January 2018

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Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)

21 January 2018

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The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

21 January 2018

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Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling

21 January 2018

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TREMs in the immune system and beyond

21 January 2018

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Natural killer cell receptor signaling

21 January 2018

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Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

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Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack

21 January 2018

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Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

21 January 2018

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Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells

21 January 2018

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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

21 January 2018

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 January 2018

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Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

21 January 2018

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Functional association between SLAP-130 and SLP-76 in Jurkat T cells

21 January 2018

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Coupling of the TCR to integrin activation by Slap-130/Fyb.

21 January 2018

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Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

21 January 2018

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Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes.

21 January 2018

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Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction

21 January 2018

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

21 January 2018

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Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

31 March 2020

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Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells

31 March 2020

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LAT is essential for Fc(epsilon)RI-mediated mast cell activation

31 March 2020

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Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

31 March 2020

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LAT links the pre-BCR to calcium signaling

31 March 2020

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Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly

31 March 2020

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Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

31 March 2020

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Adapters in lymphocyte signaling

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1414

1 reference

10 August 2017

1 reference

PubMed ID

15286727