(Q38005192)

26 August 2017

title

PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis? (English)

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26 August 2017

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Mari Nowell

1

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26 August 2017

Laura Evans

series ordinal

2

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26 August 2017

Anwen Williams

series ordinal

3

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26 August 2017

publication date

1 April 2012

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Future Medicinal Chemistry

26 August 2017

published in

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26 August 2017

volume

4

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26 August 2017

issue

6

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26 August 2017

page(s)

751-769

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Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

26 August 2017

cites work

1 reference

Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence

21 January 2018

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Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

21 January 2018

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RETRACTED: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

21 January 2018

1 reference

Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.

21 January 2018

1 reference

Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.

21 January 2018

1 reference

The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance

21 January 2018

1 reference

Nampt: linking NAD biology, metabolism and cancer

21 January 2018

1 reference

The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase.

21 January 2018

1 reference

CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes

21 January 2018

1 reference

Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor

21 January 2018

1 reference

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

21 January 2018

1 reference

NAD+ metabolism in health and disease

21 January 2018

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Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.

21 January 2018

1 reference

Genes expressed during the IFN gamma-induced maturation of pre-B cells

21 January 2018

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Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes

21 January 2018

1 reference

Fetal membrane distention: I. Differentially expressed genes regulated by acute distention in amniotic epithelial (WISH) cells

21 January 2018

1 reference

Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1.

21 January 2018

1 reference

Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

21 January 2018

1 reference

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

21 January 2018

1 reference

Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

21 January 2018

1 reference

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

21 January 2018

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Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation

21 January 2018

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Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress

21 January 2018

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

21 January 2018

1 reference

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.

21 January 2018

1 reference

Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation.

21 January 2018

1 reference

Human Sir2 and the 'silencing' of p53 activity

21 January 2018

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Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue

21 January 2018

1 reference

Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

21 January 2018

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Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling

21 January 2018

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Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

21 January 2018

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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

21 January 2018

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NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway

21 January 2018

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Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

21 January 2018

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Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans

21 January 2018

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Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities

21 January 2018

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Plasma visfatin concentrations and fat depot-specific mRNA expression in humans

21 January 2018

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The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals

21 January 2018

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Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis

21 January 2018

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Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway

21 January 2018

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Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes

21 January 2018

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Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway

21 January 2018

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Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol

21 January 2018

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A key role for Pre-B cell colony-enhancing factor in experimental hepatitis

21 January 2018

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Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis

21 January 2018

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Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury

21 January 2018

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Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD.

21 January 2018

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Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.

21 January 2018

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Peritoneal fluid adipokines: ready for prime time?

21 January 2018

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Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition

21 January 2018

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Relationship between cerebrospinal fluid visfatin (PBEF/Nampt) levels and adiposity in humans

21 January 2018

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Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis.

21 January 2018

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Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

21 January 2018

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TNF regulates cellular NAD+ metabolism in primary macrophages

21 January 2018

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Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization

21 January 2018

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Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas.

21 January 2018

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A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization

21 January 2018

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Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes

21 January 2018

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Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis.

21 January 2018

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Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

21 January 2018

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Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals

21 January 2018

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Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

21 January 2018

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Signatures of the immune response

21 January 2018

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Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy

21 January 2018

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The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

21 January 2018

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Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD

21 January 2018

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Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

21 January 2018

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Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866

21 January 2018

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The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases

21 January 2018

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In vivo molecular imaging of experimental joint inflammation by combined (18)F-FDG positron emission tomography and computed tomography.

21 January 2018

1 reference

Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study

21 January 2018

1 reference

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

21 January 2018

1 reference

A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor.

21 January 2018

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Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.

21 January 2018

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Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor

21 January 2018

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Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents.

21 January 2018

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In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients

21 January 2018

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Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro

21 January 2018

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The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors

21 January 2018

1 reference

Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action

21 January 2018

1 reference

A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

21 January 2018

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Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).

21 January 2018

1 reference

A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase.

21 January 2018

1 reference

Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention

21 January 2018

1 reference

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.

21 January 2018

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Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future.

21 January 2018

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Molecular mechanisms of sulfasalazine-induced T-cell apoptosis

21 January 2018

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The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.12.34

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26 August 2017

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