(Q38009932)

English

Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia

scientific article published on 28 May 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Alzheimer's disease

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apoptotic process

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1 reference

based on heuristic

inferred from title

cerebral infarction

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

toxic encephalopathy

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based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

author name string

Jiu-Haw Yin

2

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Europe PubMed Central

PubMed publication ID

26 August 2017

Chi-Shin Hwang

3

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Ching-Min Tang

4

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Ding-I Yang

5

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

publication date

28 May 2012

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Free Radical Research

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

46

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

8

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Europe PubMed Central

PubMed publication ID

26 August 2017

940-950

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Europe PubMed Central

PubMed publication ID

26 August 2017

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Membrane dynamics and cell polarity: the role of sphingolipids

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury?

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide and mitochondria in ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Tetracycline absorption in elderly patients with achlorhydria

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Principles of bioactive lipid signalling: lessons from sphingolipids

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Lipid signalling in disease.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Sphingolipids in apoptosis, survival and regeneration in the nervous system

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Purification and characterization of ceramide-activated protein phosphatases

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mitochondrial intermembrane proteins in cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

The role of mitochondria in apoptosis*.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

The pathophysiology of mitochondrial cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mitochondrial control of apoptosis: an overview

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline: stain devil?

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Tetracyclines: nonantibiotic properties and their clinical implications

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Chemical and biological dynamics of tetracyclines.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Prospects for minocycline neuroprotection

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline provides protection against beta-amyloid(25-35)-induced alterations of the somatostatin signaling pathway in the rat temporal cortex.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline delays disease onset and mortality in a transgenic model of ALS.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP).

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Antioxidant potential of Minocycline in Japanese Encephalitis Virus infection in murine neuroblastoma cells: correlation with membrane fluidity and cell death

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Ceramide synthases: roles in cell physiology and signaling

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.674640

21 January 2018

Identifiers

10.3109/10715762.2012.674640

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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