(Q38018004)

27 August 2017

title

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium (English)

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27 August 2017

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1 reference

3

Markus F Neurath

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27 August 2017

Claudia Günther

1

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27 August 2017

Helmut Neumann

series ordinal

2

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27 August 2017

Christoph Becker

series ordinal

4

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27 August 2017

language of work or name

English

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publication date

11 June 2012

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27 August 2017

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27 August 2017

volume

62

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27 August 2017

issue

7

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27 August 2017

page(s)

1062-1071

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The intestinal epithelial stem cell

27 August 2017

cites work

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Live and let die in the intestinal epithelium

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The multifaceted Paneth cell

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Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

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The intestinal stem cell

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The gastrointestinal tract stem cell niche

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Epithelial cell differentiation in normal and transgenic mouse intestinal isografts

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Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

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Intestinal homeostasis and its breakdown in inflammatory bowel disease

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Metastasis: a question of life or death

21 January 2018

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Regulation of apoptosis during homeostasis and disease in the intestinal epithelium

21 January 2018

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Alternative cell death mechanisms in development and beyond

21 January 2018

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Epithelial barrier function in vivo is sustained despite gaps in epithelial layers

21 January 2018

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Characterization of epithelial cell shedding from human small intestine.

21 January 2018

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The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding.

21 January 2018

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Caspase deficiency alters the murine gut microbiome

21 January 2018

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Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.

21 January 2018

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RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

21 January 2018

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

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https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

21 January 2018

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https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Necrosis and apoptosis in the gastrointestinal tract

21 January 2018

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https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestine

21 January 2018

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https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

21 January 2018

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https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

XBP1: the last two decades

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Increase in colorectal epithelial apoptotic cells in patients with ulcerative colitis ultimately requiring surgery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Apoptosis of intestinal crypt epithelium after Cryptosporidium parvum infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Necrosis: a specific form of programmed cell death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Necrosis is an active and controlled form of programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Molecular mechanisms and pathophysiology of necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Induction of necrosis in human neutrophils by Shigella flexneri requires type III secretion, IpaB and IpaC invasins, and actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The Paneth cell in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Structure-activity relationship study of novel necroptosis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Caspase-independent cell death: leaving the set without the final cut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Necroptosis as an alternative form of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Mechanisms of necroptosis in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Non-apoptotic functions of caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Nonapoptotic functions of FADD-binding death receptors and their signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Fas and Fas ligand: lpr and gld mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Regulation and function of IKK and IKK-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

21 January 2018

Death receptor signaling

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Programmed necrosis: backup to and competitor with apoptosis in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The Ripoptosome: death decision in the cytosol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The role of c-FLIP in modulation of CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Life and death in peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Death receptor-induced cell killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

cFLIP regulation of lymphocyte activation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Inhibition of death receptor signals by cellular FLIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Activation of caspases-8 and -10 by FLIP(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Transcriptional and post-translational regulation of Flip, an inhibitor of Fas-mediated apoptosis, in human gut inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

The fundamental basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Paneth cells: their role in innate immunity and inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Role of cytokines in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

New therapeutic strategies for treatment of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Linkage of inflammatory bowel disease to human chromosome 6p

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Certolizumab pegol for the treatment of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2011-301364

10.1136/GUTJNL-2011-301364

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference