(Q36858872)

16 August 2017

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title

Life and death in peripheral T cells (English)

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16 August 2017

Peter H Krammer

1

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PubMed ID

17589543

16 August 2017

Rüdiger Arnold

series ordinal

2

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PubMed ID

17589543

16 August 2017

Inna N Lavrik

series ordinal

3

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16 August 2017

1 July 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

532-542

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16 August 2017

7

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Negative selection--clearing out the bad apples from the T-cell repertoire

16 August 2017

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T-lymphocyte death during shutdown of an immune response

31 March 2020

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The role of CD95 in the regulation of peripheral T-cell apoptosis

31 March 2020

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How T lymphocytes switch between life and death

31 March 2020

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Lysosomes and autophagy in cell death control

31 March 2020

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Molecular mechanisms of activated T cell death in vivo

31 March 2020

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CD95's deadly mission in the immune system

31 March 2020

1 reference

31 March 2020

Death receptor signaling

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Caspases: pharmacological manipulation of cell death

31 March 2020

1 reference

31 March 2020

Caspases: enemies within

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Death receptors: signaling and modulation

31 March 2020

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A novel domain within the 55 kd TNF receptor signals cell death

31 March 2020

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The CD95(APO-1/Fas) DISC and beyond

31 March 2020

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FADD self-association is required for stable interaction with an activated death receptor

31 March 2020

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A unified model for apical caspase activation

31 March 2020

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Interdimer processing mechanism of procaspase-8 activation.

31 March 2020

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An induced proximity model for caspase-8 activation.

31 March 2020

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

31 March 2020

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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

31 March 2020

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Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

31 March 2020

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Two CD95 (APO-1/Fas) signaling pathways

31 March 2020

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

31 March 2020

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Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death

31 March 2020

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

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Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

31 March 2020

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Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort

31 March 2020

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Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

31 March 2020

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An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death

31 March 2020

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TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

31 March 2020

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CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

31 March 2020

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Fas engagement induces neurite growth through ERK activation and p35 upregulation

31 March 2020

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Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds

31 March 2020

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Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).

31 March 2020

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

31 March 2020

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NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

31 March 2020

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Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.

31 March 2020

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cFLIP regulation of lymphocyte activation and development

31 March 2020

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The relevance of NF-kappaB for CD95 signaling in tumor cells.

31 March 2020

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BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

31 March 2020

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Mitochondrial membrane permeabilization in cell death

31 March 2020

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The role of BH3-only proteins in the immune system

31 March 2020

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

31 March 2020

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Activation-driven programmed cell death and T cell receptor zeta eta expression

31 March 2020

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Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes.

31 March 2020

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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

31 March 2020

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Monoclonal antibody-mediated tumor regression by induction of apoptosis.

31 March 2020

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The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.

31 March 2020

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CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

31 March 2020

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Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

31 March 2020

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Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

31 March 2020

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Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells

31 March 2020

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Activation-induced cell death in T cells

31 March 2020

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

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Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer

31 March 2020

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HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death

31 March 2020

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Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

31 March 2020

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Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death

31 March 2020

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Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways

31 March 2020

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

31 March 2020

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

31 March 2020

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T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis

31 March 2020

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Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.

31 March 2020

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In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.

31 March 2020

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

31 March 2020

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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

31 March 2020

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Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering.

31 March 2020

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

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Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected].

31 March 2020

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Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation

31 March 2020

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Lysosomal cysteine proteases: facts and opportunities

31 March 2020

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Granzyme B: a natural born killer

31 March 2020

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Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

31 March 2020

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Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion

31 March 2020

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Glucocorticoids engage different signal transduction pathways to induce apoptosis in thymocytes and mature T cells

31 March 2020

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Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

31 March 2020

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Regulation of lymphocyte proliferation and death by FLIP.

31 March 2020

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c-FLIPR, a new regulator of death receptor-induced apoptosis.

31 March 2020

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Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

31 March 2020

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The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

31 March 2020

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c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

31 March 2020

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The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

31 March 2020

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NF-kappaB at the crossroads of life and death

31 March 2020

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From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-kappaB.

31 March 2020

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Missing pieces in the NF-kappaB puzzle

31 March 2020

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31 March 2020

Signaling to NF-kappaB

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

31 March 2020

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Deciphering the pathway from the TCR to NF-kappaB

31 March 2020

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The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

31 March 2020

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Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

31 March 2020

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An essential role for c-FLIP in the efficient development of mature T lymphocytes

31 March 2020

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Cellular FLICE-inhibitory protein is required for T cell survival and cycling

31 March 2020

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Activation of the NF-kappaB pathway by caspase 8 and its homologs

31 March 2020

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Activation of NF-kappaB by FADD, Casper, and caspase-8.

31 March 2020

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

31 March 2020

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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

31 March 2020

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Caspase activation is required for T cell proliferation

31 March 2020

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

31 March 2020

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

31 March 2020

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

31 March 2020

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CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.

31 March 2020

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The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function

31 March 2020

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Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.

31 March 2020

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Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells

31 March 2020

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Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death

31 March 2020

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NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes.

31 March 2020

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Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis

31 March 2020

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

31 March 2020

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

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Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

31 March 2020

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Control of Bcl-2 expression by reactive oxygen species

31 March 2020

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The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression

31 March 2020

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

31 March 2020

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Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB

31 March 2020

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Caspases in cell survival, proliferation and differentiation.

31 March 2020

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Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates

31 March 2020

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The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation

31 March 2020

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In vitro generated human memory-like T cells are CD95 type II cells and resistant towards CD95-mediated apoptosis.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2115

1 reference

16 August 2017

1 reference

PubMed ID

17589543