(Q38018995)

27 August 2017

DNA methylation biomarkers in cancer: progress towards clinical implementation (English)

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27 August 2017

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27 August 2017

4

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27 August 2017

Thomas Mikeska

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author name string

Hongdo Do

series ordinal

3

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PubMed ID

22702364

27 August 2017

language of work or name

English

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publication date

1 June 2012

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

27 August 2017

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27 August 2017

12

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27 August 2017

473-487

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27 August 2017

5

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Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

27 August 2017

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Aberrant DNA methylation in contrast with mutations

21 January 2018

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Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

21 January 2018

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CpG-rich islands and the function of DNA methylation

21 January 2018

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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The DNA methylation paradox

21 January 2018

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Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research

21 January 2018

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DNA hypomethylation in cancer cells

21 January 2018

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High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

21 January 2018

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Genome-wide DNA methylation profiles in precancerous conditions and cancers

21 January 2018

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Identification of driver and passenger DNA methylation in cancer by epigenomic analysis

21 January 2018

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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

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Epigenetic stem cell signature in cancer

21 January 2018

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PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment

21 January 2018

1 reference

Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.

21 January 2018

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DNA methylation as a universal biomarker

21 January 2018

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CpG methylation analysis--current status of clinical assays and potential applications in molecular diagnostics: a report of the Association for Molecular Pathology.

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

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Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives

21 January 2018

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Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection

21 January 2018

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Bisulfite genomic sequencing: systematic investigation of critical experimental parameters

21 January 2018

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Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA.

21 January 2018

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Reversal of PCR bias for improved sensitivity of the DNA methylation melting curve assay.

21 January 2018

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Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis.

21 January 2018

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The implications of heterogeneous DNA methylation for the accurate quantification of methylation

21 January 2018

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Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

21 January 2018

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Effect of fixatives and tissue processing on the content and integrity of nucleic acids

21 January 2018

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Analysing DNA methylation using bisulphite pyrosequencing.

21 January 2018

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Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools

21 January 2018

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Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring

21 January 2018

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Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

21 January 2018

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Methylation-sensitive high-resolution melting in the context of legislative requirements for validation of analytical procedures for diagnostic applications

21 January 2018

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Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

21 January 2018

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Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements

21 January 2018

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Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip.

21 January 2018

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Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed, paraffin-embedded paired tumor and normal tissue

21 January 2018

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Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.

21 January 2018

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Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA.

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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Determination of the methylation status of MGMT in different regions within glioblastoma multiforme.

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

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Single-molecule polymerase chain reaction reduces bias: application to DNA methylation analysis by bisulfite sequencing

21 January 2018

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Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

21 January 2018

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Sensitive digital quantification of DNA methylation in clinical samples

21 January 2018

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Continuous base identification for single-molecule nanopore DNA sequencing

21 January 2018

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Direct detection of DNA methylation during single-molecule, real-time sequencing

21 January 2018

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Computational epigenetics

21 January 2018

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Epigenetic biomarker development

21 January 2018

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MethPrimer: designing primers for methylation PCRs

21 January 2018

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BiSearch: primer-design and search tool for PCR on bisulfite-treated genomes

21 January 2018

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MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

21 January 2018

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BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.

21 January 2018

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QUMA: quantification tool for methylation analysis

21 January 2018

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BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing

21 January 2018

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A pipeline for the quantitative analysis of CG dinucleotide methylation using mass spectrometry

21 January 2018

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Methyl-Typing: an improved and visualized COBRA software for epigenomic studies.

21 January 2018

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DNA methylation, epimutations and cancer predisposition

21 January 2018

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BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype

21 January 2018

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Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

21 January 2018

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Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer

21 January 2018

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Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions

21 January 2018

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Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.

21 January 2018

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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

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Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers

21 January 2018

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Cigarette smoking and p16INK4α gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis

21 January 2018

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Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer

21 January 2018

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In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins

21 January 2018

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Gene promoter methylation in plasma and sputum increases with lung cancer risk.

21 January 2018

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SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates

21 January 2018

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Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors

21 January 2018

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Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-captur

21 January 2018

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DNA-based detection of prostate cancer in urine after prostatic massage

21 January 2018

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DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients

21 January 2018

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DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaborati

21 January 2018

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Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients

21 January 2018

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DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy.

21 January 2018

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DNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker of biochemical recurrence in patients with prostate cancer after radical prostatectomy.

21 January 2018

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Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer

21 January 2018

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DNA methylation markers and early recurrence in stage I lung cancer

21 January 2018

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Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

21 January 2018

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Pharmaco(epi)genomics in ovarian cancer

21 January 2018

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Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter.

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

21 January 2018

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The use of temozolomide for the treatment of malignant tumors: clinical evidence and molecular mechanisms of action

21 January 2018

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Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

21 January 2018

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Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.

21 January 2018

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Primer extension based quantitative polymerase chain reaction reveals consistent differences in the methylation status of the MGMT promoter in diffusely infiltrating gliomas (WHO grade II-IV) of adults.

21 January 2018

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Cancer epigenomics: implications of DNA methylation in personalized cancer therapy

21 January 2018

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Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

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Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

21 January 2018

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The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer

21 January 2018

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Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors.

21 January 2018

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Mismatch repair proficiency and in vitro response to 5-fluorouracil

21 January 2018

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Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance

21 January 2018

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Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

21 January 2018

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TFAP2E-DKK4 and chemoresistance in colorectal cancer

21 January 2018

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Targeting DNA methylation

21 January 2018

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DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes

21 January 2018

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Azacytidine causes complex DNA methylation responses in myeloid leukemia

21 January 2018

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Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

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Genome-wide DNA methylation profiling using Infinium® assay

21 January 2018

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Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

21 January 2018

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Analysis of complex methylation data

21 January 2018

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Methylated genes as new cancer biomarkers.

21 January 2018

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BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

21 January 2018

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SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in Plasma

21 January 2018

1 reference

Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens.

21 January 2018

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.5414/NPP27388

Identifiers

DOI

10.1586/ERM.12.45

1 reference

27 August 2017

1 reference

PubMed ID

22702364