(Q38025056)

27 August 2017

Recent advances in targeted genome engineering in mammalian systems (English)

1 reference

27 August 2017

Ning Sun

1

1 reference

PubMed ID

22777886

27 August 2017

Zhanar Abil

series ordinal

2

1 reference

PubMed ID

22777886

27 August 2017

Huimin Zhao

series ordinal

3

1 reference

27 August 2017

10 July 2012

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27 August 2017

Biotechnology Journal

1 reference

27 August 2017

7

1 reference

27 August 2017

9

1 reference

27 August 2017

1074-1087

1 reference

Homing endonucleases: from basics to therapeutic applications.

27 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene therapy death prompts review of adenovirus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Precise targeted integration by a chimaeric transposase zinc-finger fusion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

An update on targeted gene repair in mammalian cells: methods and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A highly sensitive selection method for directed evolution of homing endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Directed evolution and substrate specificity profile of homing endonuclease I-SceI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Directed evolution of homing endonuclease I-SceI with altered sequence specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Computational redesign of endonuclease DNA binding and cleavage specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Exploitation of binding energy for catalysis and design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Heritable targeted mutagenesis in maize using a designed endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Tapping natural reservoirs of homing endonucleases for targeted gene modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene targeting using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

FokI dimerization is required for DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Genome Engineering With Zinc-Finger Nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Zinc-finger nucleases: the next generation emerges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Genome editing with engineered zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

An unbiased genome-wide analysis of zinc-finger nuclease specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Knockout rats via embryo microinjection of zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Inversion variants in the human genome: role in disease and genome architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Chromosomal translocations induced at specified loci in human stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted chromosomal deletions in human cells using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Recurrent inversion breaking intron 1 of the factor VIII gene is a frequent cause of severe hemophilia A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Xanthomonas AvrBs3 family-type III effectors: discovery and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

TAL effectors are remote controls for gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A simple cipher governs DNA recognition by TAL effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Heritable gene targeting in zebrafish using customized TALENs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A TALE nuclease architecture for efficient genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A one pot, one step, precision cloning method with high throughput capability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Transcriptional activators of human genes with programmable DNA-specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Assembly of custom TALE-type DNA binding domains by modular cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Assembly of designer TAL effectors by Golden Gate cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A transcription activator-like effector toolbox for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

TAL effectors: customizable proteins for DNA targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

TALE nucleases: tailored genome engineering made easy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Genetic engineering of human pluripotent cells using TALE nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Tracking genome engineering outcome at individual DNA breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted integration in rat and mouse embryos with zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene targeting with viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A novel directed evolution method to enhance cell-type specificity of adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted genome modifications using integrase-deficient lentiviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Targeted gene modification in mouse ES cells using integrase-defective lentiviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200038

21 January 2018

Identifiers

DOI

10.1002/BIOT.201200038

1 reference

27 August 2017

1 reference

PubMed ID

22777886