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Zinc-finger nucleases: the next generation emerges
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title
Zinc-finger nucleases: the next generation emerges
(English)
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author
Toni Cathomen
series ordinal
1
object named as
Toni Cathomen
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J. Keith Joung
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2
object named as
J Keith Joung
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language of work or name
English
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publication date
July 2008
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published in
Molecular Therapy
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volume
16
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page(s)
1200-7
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issue
7
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cites work
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
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Gene targeting using zinc finger nucleases
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Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells
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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
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Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy
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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain
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Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
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Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
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Mechanism and regulation of human non-homologous DNA end-joining
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Efficient gene targeting in Drosophila with zinc-finger nucleases
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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.
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Genetic therapies against HIV.
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Manipulating the mammalian genome by homologous recombination
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Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae
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Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells
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Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells
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Highly efficient endogenous human gene correction using designed zinc-finger nucleases
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inferred from DOI database lookup
HIV and the chemokine system: 10 years later
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https://api.crossref.org/works/10.1038%2FMT.2008.114
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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
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https://api.crossref.org/works/10.1038%2FMT.2008.114
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Targeted genome modifications using integrase-deficient lentiviral vectors.
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DNA recognition by Cys2His2 zinc finger proteins
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reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
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inferred from DOI database lookup
Design and selection of novel Cys2His2 zinc finger proteins
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https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
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inferred from DOI database lookup
Drug discovery with engineered zinc-finger proteins
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https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Engineering polydactyl zinc-finger transcription factors
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Towards therapeutic applications of engineered zinc finger proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Custom DNA-binding proteins and artificial transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
The design of functional DNA-binding proteins based on zinc finger domains.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Validated zinc finger protein designs for all 16 GNN DNA triplet targets
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
A zinc finger directory for high-affinity DNA recognition
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc finger phage: affinity selection of fingers with new DNA-binding specificities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Building zinc fingers by selection: toward a therapeutic application
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toward rules relating zinc finger protein sequences and DNA binding site preferences
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human zinc fingers as building blocks in the construction of artificial transcription factors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Designing transcription factor architectures for drug discovery.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design, construction and in vitro testing of zinc finger nucleases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design, engineering, and characterization of zinc finger nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancing Gene Targeting with Designed Zinc Finger Nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Custom zinc-finger nucleases for use in human cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unexpected failure rates for modular assembly of engineered zinc fingers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergy between adjacent zinc fingers in sequence-specific DNA recognition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The zinc finger nuclease monopoly.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene therapy. Putting the fingers on gene repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian gene targeting with designed zinc finger nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An improved zinc-finger nuclease architecture for highly specific genome editing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene repair: pointing the finger at genetic disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chimeric nucleases stimulate gene targeting in human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adeno-associated virus vectors integrate at chromosome breakage sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spectral karyotyping analysis of human and mouse chromosomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein assembly and DNA looping by the FokI restriction endonuclease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
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7 January 2021
based on heuristic
inferred from DOI database lookup
AAV vector integration sites in mouse hepatocellular carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMT.2008.114
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/MT.2008.114
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1384595
OpenCitations bibliographic resource ID
1384595
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1384595
PubMed ID
18545224
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1384595
ResearchGate publication ID
5310506
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