(Q38050686)

English

Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.

scientific article published on 10 October 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

drug interaction

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Constanze Hilgendorf

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C Hilgendorf

2

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author name string

R Elsby

1

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

K Fenner

3

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

language of work or name

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publication date

10 October 2012

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

Clinical Pharmacology & Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

92

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Europe PubMed Central

PubMed publication ID

27 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

584-598

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The search beyond statins

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Weighing the benefits of high-dose simvastatin against the risk of myopathy.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Statin-induced myopathy: a review and update

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Role of OATP transporters in the disposition of drugs

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Transporter pharmacogenetics and statin toxicity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Relationship between drug/metabolite exposure and impairment of excretory transport function.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

SLCO1B1 variants and statin-induced myopathy--a genomewide study

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The SLCO1B1*5 genetic variant is associated with statin-induced side effects

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Simvastatin: a review

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Clinical Pharmacokinetics of Atorvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Pharmacokinetics of fluvastatin after single and multiple doses in normal volunteers

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Clinical pharmacokinetics of fluvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Pitavastatin: an overview

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Absolute oral bioavailability of rosuvastatin in healthy white adult male volunteers

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The effect of fluconazole on the pharmacokinetics of rosuvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

1 reference

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21 January 2018

Predicting drug interaction potential with a physiologically based pharmacokinetic model: a case study of telithromycin, a time-dependent CYP3A inhibitor

1 reference

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21 January 2018

Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate

1 reference

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21 January 2018

Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Mechanism-based inactivation of CYP3A by HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Role of itraconazole metabolites in CYP3A4 inhibition

1 reference

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21 January 2018

Poor solubility limiting significance of in-vitro studies with HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

21 January 2018

Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

7 January 2021

based on heuristic

inferred from DOI database lookup

Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

7 January 2021

based on heuristic

inferred from DOI database lookup

Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

7 January 2021

based on heuristic

inferred from DOI database lookup

Urolithiasis in HIV-positive patients treated with atazanavir

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2012.163

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CLPT.2012.163

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 August 2017

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