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The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.

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16 January 2020

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance (English)

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16 January 2020

protein evolution

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inferred from title

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16 January 2020

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Katherine S Fenner

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16 January 2020

Hannah M Jones

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16 January 2020

Mohammed Ullah

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16 January 2020

Sarah Kempshall

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16 January 2020

Maurice Dickins

5

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16 January 2020

Paul Morgan

7

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16 January 2020

Hugh A Barton

8

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16 January 2020

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11 November 2011

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16 January 2020

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16 January 2020

42

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16 January 2020

1

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16 January 2020

28-45

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16 January 2020

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

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Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers

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Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin

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Role of transport proteins in drug absorption, distribution and excretion

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CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

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Multidrug resistance-associated proteins 3, 4, and 5.

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Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies

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Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

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Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions

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Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.

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Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

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The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

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Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity

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Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

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Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors

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Withdrawal of cerivastatin from the world market

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Utilization of membrane vesicle preparations to study drug–ABC transporter interactions

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Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members

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Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

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21 January 2018

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

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Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations

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Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression

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https://api.crossref.org/works/10.3109%2F00498254.2011.626464

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Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

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Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus

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21 January 2018

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

1 reference

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Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

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21 January 2018

Membrane transporters in drug development

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

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SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers

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Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

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Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide

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Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2)

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Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

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Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

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Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

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ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

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Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

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Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport

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Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men.

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Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

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Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms

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In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay

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effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

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Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry

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Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes

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Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans

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Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

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The organic anion transporter (OATP) family.

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Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

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OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

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Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

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21 January 2018

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

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21 January 2018

Transporter pharmacogenetics and statin toxicity

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21 January 2018

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

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21 January 2018

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

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21 January 2018

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

1 reference

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21 January 2018

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

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Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

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21 January 2018

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

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Global analysis of genetic variation in SLCO1B1.

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21 January 2018

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

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21 January 2018

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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21 January 2018

SLCO1B1 variants and statin-induced myopathy--a genomewide study

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21 January 2018

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

1 reference

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21 January 2018

Transporters as a determinant of drug clearance and tissue distribution

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

1 reference

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21 January 2018

Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes

1 reference

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21 January 2018

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

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21 January 2018

Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

1 reference

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21 January 2018

Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

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21 January 2018

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

1 reference

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21 January 2018

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta

1 reference

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21 January 2018

Drug-drug Interaction between Pravastatin and Gemfibrozil (Antihyperlipidemic) with Gliclazide (Antidiabetic) in Rats

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers

1 reference

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21 January 2018

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

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21 January 2018

Dual effects of rifampin on the pharmacokinetics of atrasentan

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Uptake is the rate-limiting step in the overall hepatic elimination of pravastatin at steady-state in rats.

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

1 reference

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21 January 2018

Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Scientific and regulatory perspectives on metabolizing enzyme-transporter interplay and its role in drug interactions: challenges in predicting drug interactions

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Effect of fluconazole on plasma fluvastatin and pravastatin concentrations

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.626464

21 January 2018

Identifiers

10.3109/00498254.2011.626464

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22077101%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22077101%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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