(Q38055455)

27 August 2017

Stem cell-based therapy for Huntington's disease (English)

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27 August 2017

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1

Christof Maucksch

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27 August 2017

Elena M Vazey

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Bronwen Connor

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Bronwen Connor

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4

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author name string

Renee J Gordon

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3

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27 August 2017

1 April 2013

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Journal of Cellular Biochemistry

27 August 2017

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27 August 2017

114

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27 August 2017

4

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27 August 2017

754-763

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Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.

27 August 2017

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Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

21 January 2018

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Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study

21 January 2018

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Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease

21 January 2018

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Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat.

21 January 2018

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Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model

21 January 2018

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Trinucleotide repeat length and clinical progression in Huntington's disease

21 January 2018

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Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

21 January 2018

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Generating neuron-like cells from BM-derived mesenchymal stromal cells in vitro.

21 January 2018

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Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway.

21 January 2018

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Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice.

21 January 2018

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

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Cell transplantation for Huntington's disease Should we continue?

21 January 2018

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Striatal grafts in rats with unilateral neostriatal lesions--III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching.

21 January 2018

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The integration and function of striatal grafts

21 January 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

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Neural differentiation and therapeutic potential of adipose tissue derived stem cells

21 January 2018

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Neural transplantation in Huntington's disease: the NEST-UK donor tissue microbiological screening program and review of the literature

21 January 2018

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Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology

21 January 2018

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Positron emission tomography after fetal transplantation in Huntington's disease

21 January 2018

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Development of human striatal anlagen after transplantation in a patient with Huntington's disease

21 January 2018

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Striatal neural grafting improves cortical metabolism in Huntington's disease patients

21 January 2018

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Chemokines direct neural progenitor cell migration following striatal cell loss

21 January 2018

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Regional specificity of brain atrophy in Huntington's disease.

21 January 2018

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Bilateral human fetal striatal transplantation in Huntington's disease.

21 January 2018

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21 January 2018

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Rodent genetic models of Huntington disease

21 January 2018

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Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing

21 January 2018

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Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice

21 January 2018

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Benefits and risks of hosting animal cells in the human brain.

21 January 2018

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Graft-induced behavioral recovery in an animal model of Huntington disease

21 January 2018

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Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington's disease

21 January 2018

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Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

21 January 2018

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Striatal tissue transplantation in non-human primates

21 January 2018

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Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease

21 January 2018

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Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease

21 January 2018

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Morphometric studies of the neuropathological changes in choreatic diseases

21 January 2018

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Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

21 January 2018

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Wild-type huntingtin protects neurons from excitotoxicity

21 January 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

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Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model

21 January 2018

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Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease

21 January 2018

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Slowed progression in models of Huntington disease by adipose stem cell transplantation

21 January 2018

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Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes

21 January 2018

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

21 January 2018

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

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Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.

21 January 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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Human neural stem cell transplants improve motor function in a rat model of Huntington's disease

21 January 2018

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Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

21 January 2018

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Late onset of Huntington's disease

21 January 2018

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Fetal tissue transplants in animal models of Huntington's disease: the effects on damaged neuronal circuitry and behavioral deficits

21 January 2018

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

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Molecular and behavioral analysis of the R6/1 Huntington's disease transgenic mouse

21 January 2018

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Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease.

21 January 2018

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Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

21 January 2018

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Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease

21 January 2018

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Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.

21 January 2018

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Animal models of Huntington's disease

21 January 2018

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Huntington's disease: pathological mechanisms and therapeutic strategies

21 January 2018

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Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.

21 January 2018

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Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease.

21 January 2018

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Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease.

21 January 2018

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Neural transplantation in patients with Huntington's disease

21 January 2018

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Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.

21 January 2018

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Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

21 January 2018

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3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

21 January 2018

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Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

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Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra

21 January 2018

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Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

21 January 2018

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Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease

21 January 2018

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Human embryonic stem cell-derived neural precursor transplants attenuate apomorphine-induced rotational behavior in rats with unilateral quinolinic acid lesions

21 January 2018

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Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

21 January 2018

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Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

21 January 2018

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Juvenile Huntington disease

21 January 2018

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Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

21 January 2018

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Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington disease

21 January 2018

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Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease.

21 January 2018

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Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease

21 January 2018

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Transgenic rat model of Huntington's disease

21 January 2018

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21 January 2018

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21 January 2018

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Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism.

21 January 2018

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Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

21 January 2018

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A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities

21 January 2018

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Towards a transgenic model of Huntington's disease in a non-human primate

21 January 2018

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24432

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27 August 2017

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PubMed ID

23097329