(Q38061645)

28 August 2017

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title

Xenobiotic receptor humanized mice and their utility (English)

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28 August 2017

Nico Scheer

1

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28 August 2017

C Roland Wolf

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

23 November 2012

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28 August 2017

published in

Drug Metabolism Reviews

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28 August 2017

volume

45

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28 August 2017

issue

1

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28 August 2017

page(s)

110-121

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Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

28 August 2017

cites work

1 reference

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CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics

21 January 2018

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Alternatively spliced isoforms of the human constitutive androstane receptor

21 January 2018

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Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor

21 January 2018

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Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

21 January 2018

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Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation

21 January 2018

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Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

21 January 2018

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Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

21 January 2018

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PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome

21 January 2018

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Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice

21 January 2018

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Differential gene regulation by the human and mouse aryl hydrocarbon receptor

21 January 2018

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Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis

21 January 2018

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Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli

21 January 2018

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Identification of the novel splicing variants for the hPXR in human livers

21 January 2018

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The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity

21 January 2018

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Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism

21 January 2018

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Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

21 January 2018

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Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

21 January 2018

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PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

21 January 2018

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The aryl hydrocarbon receptor complex

21 January 2018

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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

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Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease

21 January 2018

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Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: extrapolation to human CYP3A4 induction potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

21 January 2018

1 reference

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The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

21 January 2018

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Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes

21 January 2018

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Use of comprehensive screening methods to detect selective human CAR activators.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes

21 January 2018

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A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

21 January 2018

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The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Rifaximin is a gut-specific human pregnane X receptor activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems

21 January 2018

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International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D recept

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Targeting Nuclear Hormone Receptors: PPARα Agonists as Potential Disease-Modifying Drugs for Rheumatoid Arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

PXR and CAR in energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The PXR is a drug target for chronic inflammatory liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Genomic profiling in nuclear receptor-mediated toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.738687

10.3109/03602532.2012.738687

21 January 2018

Identifiers

DOI

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28 August 2017

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