(Q38065303)

28 August 2017

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title

The emerging role of DNA methylation in epileptogenesis (English)

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28 August 2017

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Katja Kobow

1

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PubMed ID

23216575

28 August 2017

Ingmar Blümcke

series ordinal

2

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28 August 2017

1 December 2012

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28 August 2017

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28 August 2017

53 Suppl 9

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28 August 2017

11-20

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

28 August 2017

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Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy

21 January 2018

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Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy

21 January 2018

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Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment

21 January 2018

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Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

21 January 2018

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A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome

21 January 2018

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The DNA methyltransferases of mammals

21 January 2018

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DNA demethylation dynamics

21 January 2018

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DNA methylation patterns and epigenetic memory

21 January 2018

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Perceptions of epigenetics

21 January 2018

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The adenosine kinase hypothesis of epileptogenesis

21 January 2018

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Molecular signals of epigenetic states

21 January 2018

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Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

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A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors.

21 January 2018

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Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.

21 January 2018

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Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

21 January 2018

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Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

21 January 2018

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CpNpG methylation in mammalian cells

21 January 2018

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Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain

21 January 2018

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CpG islands and the regulation of transcription

21 January 2018

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Brain function and chromatin plasticity

21 January 2018

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Mechanisms regulating imprinted genes in clusters.

21 January 2018

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Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns.

21 January 2018

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Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview

21 January 2018

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Phenotypic plasticity and the epigenetics of human disease

21 January 2018

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Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

21 January 2018

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Recovery of learning and memory is associated with chromatin remodelling

21 January 2018

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2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure

21 January 2018

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Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

21 January 2018

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

21 January 2018

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Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis

21 January 2018

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

21 January 2018

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Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation

21 January 2018

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Reelin promoter hypermethylation in schizophrenia

21 January 2018

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Neuronal activity modifies the DNA methylation landscape in the adult brain

21 January 2018

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

1 reference

5,10-Methylenetetrahydrofolate reductase deficiency. Clinical and biochemical features of a further case

21 January 2018

1 reference

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

21 January 2018

1 reference

Kainate exposure suppresses activation of GluR2 subunit promoter in primary cultured cerebral cortical neurons through induction of RE1-silencing transcription factor.

21 January 2018

1 reference

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

21 January 2018

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Epigenetic modifications as therapeutic targets

21 January 2018

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UBE3A/E6-AP mutations cause Angelman syndrome

21 January 2018

1 reference

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors

21 January 2018

1 reference

The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?

21 January 2018

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Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy

21 January 2018

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Deletions of chromosome 15 as a cause of the Prader-Willi syndrome

21 January 2018

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Epigenetic mechanisms in memory formation.

21 January 2018

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Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.

21 January 2018

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

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Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor

21 January 2018

1 reference

Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research

21 January 2018

1 reference

Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected

21 January 2018

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21 January 2018

1 reference

DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation

21 January 2018

1 reference

Epigenetic choreographers of neurogenesis in the adult mammalian brain

21 January 2018

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Aging and epigenetics: longitudinal changes in gene-specific DNA methylation

21 January 2018

1 reference

Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors

21 January 2018

1 reference

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

21 January 2018

1 reference

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

21 January 2018

1 reference

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

21 January 2018

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Adult neural function requires MeCP2.

21 January 2018

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Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease

21 January 2018

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Cyclical DNA methylation of a transcriptionally active promoter

21 January 2018

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Covalent modification of DNA regulates memory formation

21 January 2018

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Differential DNA methylation patterns define status epilepticus and epileptic tolerance.

21 January 2018

1 reference

Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome

21 January 2018

1 reference

The transmethylation cycle in the brain of Alzheimer patients

21 January 2018

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Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation.

21 January 2018

1 reference

Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome.

21 January 2018

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DNA methylation signatures in development and aging of the human prefrontal cortex

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

21 January 2018

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Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder

21 January 2018

1 reference

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

21 January 2018

1 reference

Human morbid genetics revisited: relevance of epigenetics.

21 January 2018

1 reference

Mechanisms of epileptogenesis and potential treatment targets

21 January 2018

1 reference

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

DNA hypomethylation in the origin and pathogenesis of human diseases

21 January 2018

1 reference

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

21 January 2018

1 reference

Autoantibodies to folate receptors in the cerebral folate deficiency syndrome.

21 January 2018

1 reference

Stability and flexibility of epigenetic gene regulation in mammalian development

21 January 2018

1 reference

Genomic imprinting: parental influence on the genome

21 January 2018

1 reference

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

Molecular mechanisms of fragile X syndrome: a twenty-year perspective

21 January 2018

1 reference

Presenilin 1 gene silencing by S‐adenosylmethionine: a treatment for Alzheimer disease?

21 January 2018

1 reference

Histone modifications in kainate-induced status epilepticus.

21 January 2018

1 reference

Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures.

21 January 2018

1 reference

Mutations in NSD1 are responsible for Sotos syndrome, but are not a frequent finding in other overgrowth phenotypes.

21 January 2018

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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

21 January 2018

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The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

A randomized, controlled trial of surgery for temporal-lobe epilepsy

21 January 2018

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Active DNA demethylation: many roads lead to Rome.

21 January 2018

1 reference

Increased expression of DNA methyltransferase 1 and 3a in human temporal lobe epilepsy.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/EPI.12031

1 reference

28 August 2017

1 reference

PubMed ID

23216575