(Q37946239)

25 August 2017

title

Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview (English)

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25 August 2017

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Richard M Eglen

1

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25 August 2017

Terry Reisine

series ordinal

2

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25 August 2017

publication date

14 October 2011

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Journal of Biomolecular Screening

25 August 2017

published in

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25 August 2017

volume

16

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25 August 2017

issue

10

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25 August 2017

page(s)

1137-1152

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Epigenetic modifications and human disease

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic modifications as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Targeting DNA methylation for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

The therapeutic uses of chromatin-modifying agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic modifications in pluripotent and differentiated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Co-evolution of X-chromosome inactivation and imprinting in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic connections between autoimmune disorders and haematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic control in rheumatoid arthritis synovial fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Breast cancer methylomes establish an epigenomic foundation for metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Targeting DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Zebularine: a new drug for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Direct real time observation of base flipping by the EcoRI DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Detection and analysis of enzymatic DNA methylation of oligonucleotide substrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI-DNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Conformational transitions as determinants of specificity for the DNA methyltransferase EcoRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Tracking transcription factor complexes on DNA using total internal reflectance fluorescence protein binding microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Identification of novel DNA methylation inhibitors via a two-component reporter gene system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Chemical probes for histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Mechanisms involved in the regulation of histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

The epigenetic magic of histone lysine methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Heterochromatin revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Structural basis for H3K4 trimethylation by yeast Set1/COMPASS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Structure and mechanism of lysine-specific demethylase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Essential functions of the histone demethylase lid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic regulation of the neural transcriptome: the meaning of the marks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylase inhibitors: current status and overview of recent clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

In vivo analysis of the molecular genetics of acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Paths of convergence: sirtuins in aging and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Epigenetic regulation of RhoB loss of expression in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Peptide arrays identify isoform-selective substrates for profiling endogenous lysine deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

Profound Flanking Sequence Preference of Dnmt3a and Dnmt3b Mammalian DNA Methyltransferases Shape the Human Epigenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111417871

21 January 2018

Identifiers

DOI

10.1177/1087057111417871

1 reference

25 August 2017

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