(Q38072622)

28 August 2017

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title

Microvascular dysfunction: an emerging pathway in the pathogenesis of obesity-related insulin resistance (English)

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Coenraad Dirk Adriaan Stehouwer

28 August 2017

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series ordinal

4

object named as

Coen D A Stehouwer

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28 August 2017

Dennis M J Muris

1

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28 August 2017

Alfons J H M Houben

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2

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28 August 2017

Miranda T Schram

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3

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28 August 2017

language of work or name

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1 March 2013

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Reviews in Endocrine and Metabolic Disorders

28 August 2017

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28 August 2017

14

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28 August 2017

1

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28 August 2017

29-38

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https://scigraph.springernature.com/pub.10.1007/s11154-012-9231-7

28 August 2017

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21 January 2018

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Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal

21 January 2018

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Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

21 January 2018

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Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension.

21 January 2018

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Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease.

21 January 2018

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Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus

21 January 2018

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How monitoring of the microcirculation may help us at the bedside

21 January 2018

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Microcirculatory function monitoring at the bedside--a view from the intensive care

21 January 2018

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Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction.

21 January 2018

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Retinal microvascular abnormalities: can they predict future risk of hypertension?

21 January 2018

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Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study

21 January 2018

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Are retinal arteriolar abnormalities related to atherosclerosis?: The Atherosclerosis Risk in Communities Study.

21 January 2018

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Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)

21 January 2018

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Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide

21 January 2018

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Impaired endothelial function of the retinal vasculature in hypertensive patients

21 January 2018

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Endothelial dysfunction and pathogenesis of diabetic angiopathy

21 January 2018

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Endothelial dysfunction, cellular adhesion molecules and the metabolic syndrome

21 January 2018

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New Markers of Inflammation and Endothelial Cell Activation

21 January 2018

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A proposal linking clearance of circulating lipoproteins to tissue metabolic activity as a basis for understanding atherogenesis

21 January 2018

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Albuminuria reflects widespread vascular damage. The Steno hypothesis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Features of endothelial dysfunction in early diabetic nephropathy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Cellular mechanisms of insulin resistance

21 January 2018

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Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy

21 January 2018

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Inflammation and metabolic disorders

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Disordered lipid metabolism and the pathogenesis of insulin resistance

21 January 2018

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Vascular complications in diabetes mellitus: the role of endothelial dysfunction

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin resistance. Prosperity's plague.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Blood flow and muscle metabolism: a focus on insulin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin-induced vasodilatation: physiology or pharmacology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin sensitivity of muscle capillary recruitment in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin-induced endothelial cell cortical actin filament remodeling: a requirement for trans-endothelial insulin transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Skin capillary density and microvascular reactivity in obese subjects with and without metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Microvascular function relates to insulin sensitivity and blood pressure in normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

A relationship between insulin sensitivity and vasodilation in women with a history of preeclamptic pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Active role for the vasculature in the delivery of insulin to skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Obese but not normal-weight women with polycystic ovary syndrome are characterized by metabolic and microvascular insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Value of urinary albumin-to-creatinine ratio as a predictor of type 2 diabetes in pre-diabetic individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Retinal vascular caliber and the long-term risk of diabetes and impaired fasting glucose: the Blue Mountains Eye Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Retinal arteriolar narrowing predicts incidence of diabetes: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Regulation of adhesion molecule expression by human synovial microvascular endothelial cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Oral glucose loading attenuates endothelial function in normal individual.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

High fat diet induces central obesity, insulin resistance and microvascular dysfunction in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Free fatty acids induce insulin resistance in both cardiac and skeletal muscle microvasculature in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Inhibition of the renin-angiotensin system prevents free fatty acid-induced acute endothelial dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Cross-talk between the insulin and angiotensin signaling systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

"Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Serum Concentrations of Adiponectin and Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease in Apparently Healthy Middle-Aged Men

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-012-9231-7

Leukocyte recruitment in the microcirculation: the rolling paradigm revisited.

21 January 2018

1 reference

12 December 2020

Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake

1 reference

12 December 2020

Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice

1 reference

12 December 2020

Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment

1 reference

12 December 2020

Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease

1 reference

12 December 2020

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

1 reference

12 December 2020

Visceral and truncal subcutaneous adipose tissue are associated with impaired capillary recruitment in healthy individuals

1 reference

12 December 2020

Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production

1 reference

12 December 2020

Nitric oxide and neurally mediated regulation of skin blood flow during local heating

1 reference

12 December 2020

Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-κB pathway in rat aorta

1 reference

12 December 2020

Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance

1 reference

12 December 2020

Is measurement of endothelial dysfunction clinically useful?

1 reference

12 December 2020

Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II

1 reference

12 December 2020

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha

1 reference

12 December 2020

Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans

1 reference

12 December 2020

Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice

1 reference

12 December 2020

Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats

1 reference

12 December 2020

Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms

1 reference

12 December 2020

Evidence for a local renin angiotensin system in primary cultured human preadipocytes

1 reference

12 December 2020

Insulin-induced capillary recruitment is impaired in both lean and obese women with PCOS

1 reference

12 December 2020

Microcirculation in hypertension: a new target for treatment?

1 reference

12 December 2020

Clinical aspects of assessment of endothelial function.

1 reference

12 December 2020

Peripheral blood flow and noradrenaline responsiveness: the effect of physiological hyperinsulinemia

1 reference

12 December 2020

A prospective study of exercise and incidence of diabetes among US male physicians

1 reference

12 December 2020

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

1 reference

12 December 2020

10.1007/S11154-012-9231-7

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

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1 reference