(Q38074996)

English

Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor

scientific article published on February 2013

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scholarly article

1 reference

Europe PubMed Central

28 August 2017

1 reference

Europe PubMed Central

Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor (English)

1 reference

Europe PubMed Central

28 August 2017

0 references

type 2 diabetes

1 reference

based on heuristic

inferred from title

author name string

Mengxi Jiang

1

1 reference

Europe PubMed Central

28 August 2017

Wen Xie

2

1 reference

Europe PubMed Central

28 August 2017

language of work or name

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publication date

1 February 2013

1 reference

Europe PubMed Central

28 August 2017

Drug Metabolism Reviews

1 reference

Europe PubMed Central

28 August 2017

45

1 reference

Europe PubMed Central

28 August 2017

1

1 reference

Europe PubMed Central

28 August 2017

156-163

1 reference

Europe PubMed Central

28 August 2017

Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice

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21 January 2018

Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice

1 reference

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21 January 2018

Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital

1 reference

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21 January 2018

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

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21 January 2018

Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.

1 reference

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21 January 2018

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

1 reference

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21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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21 January 2018

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

1 reference

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21 January 2018

Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells

1 reference

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21 January 2018

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

1 reference

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21 January 2018

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

1 reference

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21 January 2018

Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.

1 reference

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21 January 2018

Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha

1 reference

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21 January 2018

Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes

1 reference

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21 January 2018

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

1 reference

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21 January 2018

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

1 reference

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21 January 2018

Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies

1 reference

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21 January 2018

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

1 reference

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21 January 2018

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.743561

21 January 2018

The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity

1 reference

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21 January 2018

Obesity, Metabolic Syndrome, and Cardiovascular Disease

1 reference

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21 January 2018

Gestational diabetes: a review of the current literature and guidelines

1 reference

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21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

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21 January 2018

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

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21 January 2018

Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor

1 reference

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21 January 2018

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

1 reference

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21 January 2018

Mechanism by which metformin reduces glucose production in type 2 diabetes

1 reference

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21 January 2018

Constitutive androstane receptor (CAR) is a xenosensor and target for therapy

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.743561

21 January 2018

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.743561

21 January 2018

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

1 reference

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21 January 2018

The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

1 reference

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21 January 2018

Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.

1 reference

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

1 reference

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21 January 2018

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

1 reference

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21 January 2018

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

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21 January 2018

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

1 reference

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21 January 2018

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

1 reference

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21 January 2018

Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor

1 reference

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21 January 2018

Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice

1 reference

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21 January 2018

Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice

1 reference

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21 January 2018

Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

1 reference

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21 January 2018

Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators

1 reference

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21 January 2018

Nuclear receptors reverse McGarry's vicious cycle to insulin resistance

1 reference

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

1 reference

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21 January 2018

Thyroid hormone is necessary for expression of constitutive androstane receptor in rat hepatocytes.

1 reference

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21 January 2018

Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice

1 reference

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21 January 2018

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism

1 reference

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21 January 2018

The SREBP pathway--insights from Insigs and insects

1 reference

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21 January 2018

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver

1 reference

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21 January 2018

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

1 reference

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21 January 2018

Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression

1 reference

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21 January 2018

Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

1 reference

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21 January 2018

MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor

1 reference

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21 January 2018

Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver

1 reference

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21 January 2018

Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice

1 reference

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21 January 2018

Consumption of a high-fat diet during pregnancy decreases the activity of cytochrome P450 3a in the livers of offspring.

1 reference

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21 January 2018

CAR and PXR: the xenobiotic-sensing receptors

1 reference

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21 January 2018

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

1 reference

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21 January 2018

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

1 reference

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21 January 2018

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

1 reference

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21 January 2018

Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat.

1 reference

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21 January 2018

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

1 reference

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21 January 2018

Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate

1 reference

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21 January 2018

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

1 reference

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21 January 2018

A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses

1 reference

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21 January 2018

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

1 reference

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Global and societal implications of the diabetes epidemic

1 reference

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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

1 reference

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21 January 2018

Identifiers

10.3109/03602532.2012.743561

1 reference

Europe PubMed Central

28 August 2017

1 reference

Europe PubMed Central

28 August 2017

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