(Q38077285)

28 August 2017

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title

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay (English)

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28 August 2017

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Akio Yamashita

1

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28 August 2017

28 January 2013

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28 August 2017

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28 August 2017

18

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28 August 2017

161-175

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28 August 2017

3

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A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

28 August 2017

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Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?

21 January 2018

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SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.

21 January 2018

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The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

21 January 2018

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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

21 January 2018

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Functional analysis of the grapevine paralogs of the SMG7 NMD factor using a heterolog VIGS-based gene depletion-complementation system.

21 January 2018

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NMD: RNA biology meets human genetic medicine

21 January 2018

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Assembly, disassembly and recycling: the dynamics of exon junction complexes

21 January 2018

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Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation

21 January 2018

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

21 January 2018

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A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

21 January 2018

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Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

21 January 2018

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NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

21 January 2018

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Suppression of the nonsense mutation in homozygous beta 0 thalassaemia

21 January 2018

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Mechanisms of deadenylation-dependent decay

21 January 2018

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The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

21 January 2018

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Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

21 January 2018

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Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

21 January 2018

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Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.

21 January 2018

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Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene

21 January 2018

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Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

21 January 2018

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Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression

21 January 2018

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Looking at mRNA decay pathways through the window of molecular evolution

21 January 2018

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

21 January 2018

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3' end mRNA processing: molecular mechanisms and implications for health and disease

21 January 2018

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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

21 January 2018

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Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

21 January 2018

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SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

21 January 2018

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Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

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Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers

21 January 2018

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Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation

21 January 2018

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Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

21 January 2018

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Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

21 January 2018

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Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

21 January 2018

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Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice

21 January 2018

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SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

21 January 2018

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Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

21 January 2018

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Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

21 January 2018

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Identification of pyrimidine derivatives as hSMG-1 inhibitors

21 January 2018

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Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes

21 January 2018

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Upf1 senses 3'UTR length to potentiate mRNA decay

21 January 2018

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CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.

21 January 2018

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Regulation of nonsense-mediated mRNA decay

21 January 2018

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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

21 January 2018

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UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps

21 January 2018

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Introns play an essential role in splicing-dependent formation of the exon junction complex.

21 January 2018

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

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Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay

21 January 2018

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Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

21 January 2018

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

21 January 2018

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AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

21 January 2018

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Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

21 January 2018

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Termination and post-termination events in eukaryotic translation

21 January 2018

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N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

21 January 2018

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The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

21 January 2018

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SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

21 January 2018

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

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Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

21 January 2018

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Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

21 January 2018

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Suppression of premature termination codons as a therapeutic approach.

21 January 2018

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Testing the faux-UTR model for NMD: analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p.

21 January 2018

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Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast

21 January 2018

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Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

21 January 2018

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Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein

21 January 2018

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Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

21 January 2018

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Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

21 January 2018

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Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

21 January 2018

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

21 January 2018

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

21 January 2018

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Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin

21 January 2018

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Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

21 January 2018

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Interference of nonsense mutations with eukaryotic messenger RNA stability

21 January 2018

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Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution

21 January 2018

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Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA

21 January 2018

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

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Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

21 January 2018

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Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

21 January 2018

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The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

21 January 2018

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Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

21 January 2018

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Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

21 January 2018

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Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons

21 January 2018

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Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay

21 January 2018

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Human INT6/eIF3e is required for nonsense-mediated mRNA decay

21 January 2018

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A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

21 January 2018

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 January 2018

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N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

21 January 2018

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Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.

21 January 2018

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SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

21 January 2018

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A GFP-based reporter system to monitor nonsense-mediated mRNA decay

21 January 2018

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Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression

21 January 2018

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Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

21 January 2018

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Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

21 January 2018

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Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

21 January 2018

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Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length

21 January 2018

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Erratum: Regulation of cytoplasmic mRNA decay

21 January 2018

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RNA regulation and cancer development

21 January 2018

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

21 January 2018

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The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

21 January 2018

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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

21 January 2018

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Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes

21 January 2018

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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

21 January 2018

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The ever-increasing complexities of the exon junction complex

21 January 2018

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Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability

21 January 2018

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Molecular basis for dominantly inherited inclusion body beta-thalassemia

21 January 2018

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Binary specification of nonsense codons by splicing and cytoplasmic translation

21 January 2018

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UPF2 is a critical regulator of liver development, function and regeneration

21 January 2018

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A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation

21 January 2018

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SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

21 January 2018

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Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure

21 January 2018

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Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease

21 January 2018

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The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

21 January 2018

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The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

21 January 2018

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NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

21 January 2018

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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

21 January 2018

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Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

21 January 2018

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Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

21 January 2018

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Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

21 January 2018

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SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

21 January 2018

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The role of SMG-1 in nonsense-mediated mRNA decay.

21 January 2018

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

21 January 2018

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Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome

21 January 2018

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Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

21 January 2018

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Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

21 January 2018

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Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of ullrich disease fibroblasts

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/GTC.12033

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28 August 2017

1 reference

PubMed ID

23356578