(Q58323591)

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Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

scientific article published on 24 October 2011

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13 February 2020

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex (English)

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Europe PubMed Central

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13 February 2020

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13 February 2020

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Natsuko Izumi

1

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13 February 2020

Akio Yamashita

2

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13 February 2020

Hisashi Hirano

3

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13 February 2020

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24 October 2011

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13 February 2020

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13 February 2020

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13 February 2020

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13 February 2020

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13 February 2020

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Pathways of chaperone-mediated protein folding in the cytosol

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The Hsp90 chaperone machinery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The Hsp90 chaperone machinery: from structure to drug development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Targeting the dynamic HSP90 complex in cancer

1 reference

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21 January 2018

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Hsp90 inhibitors as promising agents for radiotherapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Inhibition of Hsp90: a multitarget approach to radiosensitization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Hsp90 regulates the Fanconi anemia DNA damage response pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Inhibition of hsp90 compromises the DNA damage response to radiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The role of SMG-1 in nonsense-mediated mRNA decay.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Orchestration of chromatin-based processes: mind the TRRAP.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

AAA+ superfamily ATPases: common structure--diverse function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

RVB1/RVB2: running rings around molecular biology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Tel2 regulates the stability of PI3K-related protein kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Subunits shared by eukaryotic nuclear RNA polymerases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

ATR: an essential regulator of genome integrity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

1 reference

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21 January 2018

The life and death of DNA-PK.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

DNA repair pathways as targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

mTOR and cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Chaperone ligand-discrimination by the TPR-domain protein Tah1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

A proteomic snapshot of the human heat shock protein 90 interactome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

HCLK2 is required for activity of the DNA damage response kinase ATR.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2011.02112.X

21 January 2018

Identifiers

10.1111/J.1349-7006.2011.02112.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21951644%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21951644%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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