(Q38079704)

28 August 2017

title

Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics (English)

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28 August 2017

main subject

Drosophila melanogaster

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Cayetano Gonzalez

1

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language of work or name

English

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publication date

7 February 2013

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28 August 2017

published in

Nature Reviews Cancer

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28 August 2017

volume

13

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28 August 2017

issue

3

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28 August 2017

page(s)

172-183

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https://scigraph.springernature.com/pub.10.1038/nrc3461

28 August 2017

exact match

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Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules

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Modeling glioma growth and invasion in Drosophila melanogaster

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A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR.

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31 March 2020

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A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

31 March 2020

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Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila

31 March 2020

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31 March 2020

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31 March 2020

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Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

31 March 2020

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Centrosome amplification can initiate tumorigenesis in flies.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

31 March 2020

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Asymmetry-defective oligodendrocyte progenitors are glioma precursors

31 March 2020

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The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells

31 March 2020

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Insights into neural stem cell biology from flies.

31 March 2020

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Mechanisms of asymmetric stem cell division

31 March 2020

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Regulating the balance between symmetric and asymmetric stem cell division in the developing brain

31 March 2020

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Epithelial cell polarity, stem cells and cancer

31 March 2020

1 reference

Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells

31 March 2020

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Drosophila asymmetric division, polarity and cancer

31 March 2020

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Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

31 March 2020

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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.

31 March 2020

1 reference

Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

31 March 2020

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PI3K and mTOR inhibitors: a new generation of targeted anticancer agents

31 March 2020

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Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.

31 March 2020

1 reference

Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth

31 March 2020

1 reference

Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization

31 March 2020

1 reference

Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts

31 March 2020

1 reference

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division

31 March 2020

1 reference

The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions

31 March 2020

1 reference

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

31 March 2020

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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

31 March 2020

1 reference

Roles of the Polycomb group proteins in stem cells and cancer

31 March 2020

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Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

31 March 2020

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Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.

31 March 2020

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Diverse tumor pathology due to distinctive patterns of JAK/STAT pathway activation caused by different Drosophila polyhomeotic alleles

31 March 2020

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The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway.

31 March 2020

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A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

31 March 2020

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Cancer/testis antigens, gametogenesis and cancer

31 March 2020

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A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

31 March 2020

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Therapeutic vaccination for cancer immunotherapy: antigen selection and clinical responses.

31 March 2020

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A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene.

31 March 2020

1 reference

Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.

31 March 2020

1 reference

LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes

31 March 2020

1 reference

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

31 March 2020

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Lessons from 60 years of pharmaceutical innovation

31 March 2020

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Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

31 March 2020

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Chemical genetics and drug screening in Drosophila cancer models

31 March 2020

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A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells

31 March 2020

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MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

31 March 2020

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Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling

31 March 2020

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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

31 March 2020

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A Drosophila model of multiple endocrine neoplasia type 2.

31 March 2020

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ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.

31 March 2020

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Drosophila as a novel therapeutic discovery tool for thyroid cancer

31 March 2020

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

31 March 2020

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Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila

31 March 2020

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Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells

31 March 2020

1 reference

Bouvardin and deoxybouvardin, antitumor cyclic hexapeptides from Bouvardia ternifolia (Rubiaceae)

31 March 2020

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A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer

31 March 2020

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Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors

31 March 2020

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

31 March 2020

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The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.

31 March 2020

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The Aurora kinase family in cell division and cancer.

31 March 2020

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12 December 2020

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

1 reference

12 December 2020

A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells.

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12 December 2020

Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

1 reference

12 December 2020

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

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12 December 2020

Drosophila in cancer research: the first fifty tumor suppressor genes

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12 December 2020

Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene

1 reference

12 December 2020

The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.

1 reference

12 December 2020

APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.

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12 December 2020

Identifiers

DOI

10.1038/NRC3461

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Dimensions Publication ID

28 August 2017

1022187268

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