(Q38079704)

28 August 2017

title

Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics (English)

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28 August 2017

main subject

Drosophila melanogaster

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Cayetano Gonzalez

1

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language of work or name

English

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publication date

7 February 2013

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28 August 2017

published in

Nature Reviews Cancer

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28 August 2017

volume

13

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28 August 2017

issue

3

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28 August 2017

page(s)

172-183

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The genome sequence of Drosophila melanogaster

28 August 2017

cites work

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Comparative genomics of the eukaryotes

31 March 2020

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Using Drosophila melanogaster to map human cancer pathways

31 March 2020

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

31 March 2020

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Notch signalling in solid tumours: a little bit of everything but not all the time

31 March 2020

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Current views on the role of Notch signaling and the pathogenesis of human leukemia

31 March 2020

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Notch inhibitors as a new tool in the war on cancer: a pathway to watch

31 March 2020

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Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

31 March 2020

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The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

31 March 2020

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Hippo signaling in Drosophila: recent advances and insights

31 March 2020

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The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

31 March 2020

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The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

31 March 2020

1 reference

The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin

31 March 2020

1 reference

Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation

31 March 2020

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

31 March 2020

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Minutes: Mutants of Drosophila autonomously affecting cell division rate

31 March 2020

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31 March 2020

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Competitive interactions between cells: death, growth, and geography

31 March 2020

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Cell competition: the embrace of death

31 March 2020

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Is cell competition relevant to cancer?

31 March 2020

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Tumor suppression by cell competition through regulation of the Hippo pathway

31 March 2020

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Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes.

31 March 2020

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Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition.

31 March 2020

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A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway

31 March 2020

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Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis

31 March 2020

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Steep differences in wingless signaling trigger Myc-independent competitive cell interactions

31 March 2020

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Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila.

31 March 2020

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Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter

31 March 2020

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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

31 March 2020

1 reference

Polo-like kinases: conservation and divergence in their functions and regulation

31 March 2020

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From Plk1 to Plk5: functional evolution of polo-like kinases

31 March 2020

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Targeting cell cycle kinases for cancer therapy

31 March 2020

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Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.

31 March 2020

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Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.

31 March 2020

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Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.

31 March 2020

1 reference

Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila

31 March 2020

1 reference

Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint

31 March 2020

1 reference

A fly's eye view of biology

31 March 2020

1 reference

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

31 March 2020

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The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway

31 March 2020

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Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster

31 March 2020

1 reference

Human APC sequesters β-catenin even in the absence of GSK-3β in a Drosophila model

31 March 2020

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DJ-1, a novel regulator of the tumor suppressor PTEN.

31 March 2020

1 reference

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

31 March 2020

1 reference

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia.

31 March 2020

1 reference

CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach.

31 March 2020

1 reference

A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor

31 March 2020

1 reference

Modeling tumor invasion and metastasis in Drosophila

31 March 2020

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Tumors of testis and midgut in aging flies.

31 March 2020

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Decrease in the lgl tumor suppressor dose in Drosophila increases survival and longevity in stress conditions

31 March 2020

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Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells

31 March 2020

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Malignant Neoplasms of Genetic Origin in Drosophila melanogaster

31 March 2020

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Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

31 March 2020

1 reference

Suppression of Malignancy by Cell Fusion

31 March 2020

1 reference

A long view of fashions in cancer research

31 March 2020

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The adult Drosophila malpighian tubules are maintained by multipotent stem cells

31 March 2020

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Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules

31 March 2020

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Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.

31 March 2020

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A Genetic Screen in Drosophila for Metastatic Behavior

31 March 2020

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scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

31 March 2020

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Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion

31 March 2020

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The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

31 March 2020

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SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

31 March 2020

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Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila.

31 March 2020

1 reference

31 March 2020

Mitochondria and cancer

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Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia.

31 March 2020

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The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc.

31 March 2020

1 reference

A drosophila model for EGFR-Ras and PI3K-dependent human glioma

31 March 2020

1 reference

Modeling glioma growth and invasion in Drosophila melanogaster

31 March 2020

1 reference

Pax genes in embryogenesis and oncogenesis

31 March 2020

1 reference

A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR.

31 March 2020

1 reference

Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma

31 March 2020

1 reference

The Drosophila lymph gland as a developmental model of hematopoiesis

31 March 2020

1 reference

The hematopoietic stem cell and its niche: a comparative view

31 March 2020

1 reference

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

31 March 2020

1 reference

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

31 March 2020

1 reference

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

31 March 2020

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Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila

31 March 2020

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The adult Drosophila posterior midgut is maintained by pluripotent stem cells.

31 March 2020

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Evidence that stem cells reside in the adult Drosophila midgut epithelium.

31 March 2020

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Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila

31 March 2020

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Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation

31 March 2020

1 reference

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia

31 March 2020

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Intestinal stem cell function in Drosophila and mice

31 March 2020

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EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila

31 March 2020

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Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut

31 March 2020

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Genomic instability--an evolving hallmark of cancer

31 March 2020

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Losing balance: the origin and impact of aneuploidy in cancer

31 March 2020

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Cancer chromosomal instability: therapeutic and diagnostic challenges

31 March 2020

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Chromosomal instability and aneuploidy in cancer: from yeast to man

31 March 2020

1 reference

Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres

31 March 2020

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An analysis of the process of structural change in chromosomes ofDrosophila

31 March 2020

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Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster

31 March 2020

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A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity

31 March 2020

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Error-prone polyploid mitosis during normal Drosophila development

31 March 2020

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Centrosome amplification in tumorigenesis

31 March 2020

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Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

31 March 2020

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Centrosome amplification can initiate tumorigenesis in flies.

31 March 2020

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A mechanism linking extra centrosomes to chromosomal instability

31 March 2020

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Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

31 March 2020

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DNA breaks and chromosome pulverization from errors in mitosis

31 March 2020

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Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability.

31 March 2020

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Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

31 March 2020

1 reference

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis

31 March 2020

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Imaging hematopoietic precursor division in real time

31 March 2020

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Alterations of the Notch pathway in lung cancer.

31 March 2020

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

31 March 2020

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Asymmetry-defective oligodendrocyte progenitors are glioma precursors

31 March 2020

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The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells

31 March 2020

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Insights into neural stem cell biology from flies.

31 March 2020

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Mechanisms of asymmetric stem cell division

31 March 2020

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Regulating the balance between symmetric and asymmetric stem cell division in the developing brain

31 March 2020

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Epithelial cell polarity, stem cells and cancer

31 March 2020

1 reference

Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells

31 March 2020

1 reference

Drosophila asymmetric division, polarity and cancer

31 March 2020

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Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

31 March 2020

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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.

31 March 2020

1 reference

Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

31 March 2020

1 reference

PI3K and mTOR inhibitors: a new generation of targeted anticancer agents

31 March 2020

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Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.

31 March 2020

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Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth

31 March 2020

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Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization

31 March 2020

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Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts

31 March 2020

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The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division

31 March 2020

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The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions

31 March 2020

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A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

31 March 2020

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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

31 March 2020

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Roles of the Polycomb group proteins in stem cells and cancer

31 March 2020

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Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

31 March 2020

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Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.

31 March 2020

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Diverse tumor pathology due to distinctive patterns of JAK/STAT pathway activation caused by different Drosophila polyhomeotic alleles

31 March 2020

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The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway.

31 March 2020

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A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

31 March 2020

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Cancer/testis antigens, gametogenesis and cancer

31 March 2020

1 reference

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

31 March 2020

1 reference

Therapeutic vaccination for cancer immunotherapy: antigen selection and clinical responses.

31 March 2020

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A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene

31 March 2020

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Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.

31 March 2020

1 reference

LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes

31 March 2020

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Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

31 March 2020

1 reference

Lessons from 60 years of pharmaceutical innovation

31 March 2020

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Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

31 March 2020

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Chemical genetics and drug screening in Drosophila cancer models

31 March 2020

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A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells

31 March 2020

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MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

31 March 2020

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Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling

31 March 2020

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An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

31 March 2020

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A Drosophila model of multiple endocrine neoplasia type 2.

31 March 2020

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ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma.

31 March 2020

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Drosophila as a novel therapeutic discovery tool for thyroid cancer

31 March 2020

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

31 March 2020

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Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila

31 March 2020

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Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells

31 March 2020

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Bouvardin and deoxybouvardin, antitumor cyclic hexapeptides from Bouvardia ternifolia (Rubiaceae)

31 March 2020

1 reference

A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer

31 March 2020

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Reappraisal of the Hansemann-Boveri hypothesis on the origin of tumors

31 March 2020

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

31 March 2020

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The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.

31 March 2020

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The Aurora kinase family in cell division and cancer.

31 March 2020

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12 December 2020

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

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12 December 2020

A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells.

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12 December 2020

Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

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12 December 2020

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

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12 December 2020

Drosophila in cancer research: the first fifty tumor suppressor genes

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12 December 2020

Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene

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12 December 2020

The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.

1 reference

12 December 2020

APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.

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12 December 2020

Identifiers

DOI

10.1038/NRC3461

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Dimensions Publication ID

28 August 2017

1022187268

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