(Q38082475)

28 August 2017

title

Colorectal cancer: a researcher's perspective of the molecular angel's gone eccentric in the Vale of Kashmir (English)

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28 August 2017

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Aga Syed Sameer

1

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28 August 2017

publication date

17 February 2013

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28 August 2017

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28 August 2017

volume

34

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28 August 2017

issue

3

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28 August 2017

page(s)

1301-1315

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28 August 2017

cites work

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A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

21 January 2018

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Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area.

21 January 2018

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Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area

21 January 2018

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SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.

21 January 2018

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Incidence of colorectal cancer in Kashmir valley, India

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Genetic alterations during colorectal-tumor development

21 January 2018

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The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.

21 January 2018

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A genetic model for colorectal tumorigenesis

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Microsatellite instability and colorectal cancer prognosis.

21 January 2018

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High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability

21 January 2018

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APC mutations and other genetic and epigenetic changes in colon cancer.

21 January 2018

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Role of APC and DNA mismatch repair genes in the development of colorectal cancers

21 January 2018

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Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 January 2018

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The p53 tumour suppressor gene

21 January 2018

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Clinical implications of the p53 tumor-suppressor gene

21 January 2018

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Mutational spectrum of conserved regions of TP53 and PTEN genes in Kangri cancer (of the skin) in the Kashmiri population

21 January 2018

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Assessing TP53 status in human tumours to evaluate clinical outcome

21 January 2018

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Proteins regulating Ras and its relatives

21 January 2018

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The Ras signal transduction pathway

21 January 2018

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Hyperactive Ras in developmental disorders and cancer

21 January 2018

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Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

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21 January 2018

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Qualitative analysis of Adenomatous Polyposis Coli promoter: hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker.

21 January 2018

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A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

21 January 2018

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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

21 January 2018

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Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

21 January 2018

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Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

The role of the Wnt signalling pathway in colorectal tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Smads as transcriptional co-modulators

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Regulation of Smad activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers

21 January 2018

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Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

21 January 2018

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Studying genetic variations in cancer prognosis (and risk): a primer for clinicians

21 January 2018

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Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis

21 January 2018

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High-density single-nucleotide polymorphism maps of the human genome.

21 January 2018

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Association of TP53 intron 3, 16 bp duplication polymorphism with esophageal and gastric cancer susceptibility in Kashmir Valley

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Role of NQO1 609C>T and NQO2-3423G>A polymorphisms in susceptibility to gastric cancer in Kashmir valley

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley: a high risk area.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

p53 polymorphisms: cancer implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Polymorphic variants in the p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Polymorphisms in the p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Two polymorphic variants of wild-type p53 differ biochemically and biologically

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

The codon 47 polymorphism in p53 is functionally significant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Modulation of oxidative mutagenesis and carcinogenesis by polymorphic forms of human DNA repair enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Pi-class glutathione S-transferase: regulation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Human DNA repair systems: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

21 January 2018

Human DNA repair genes

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Solution structure of the single-strand break repair protein XRCC1 N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Simultaneous monitoring of P53 protein and dna content of colorectal adenocarcinomas by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0692-4

Association of bladder cancer risk with an NAD(P)H:quinone oxidoreductase polymorphism in an ethnic Kashmiri population

21 January 2018

1 reference

12 December 2020

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility

1 reference

12 December 2020

Functional studies of a germ-line polymorphism at codon 47 within the p53 gene

1 reference

12 December 2020

GSTP1 I105V polymorphism and susceptibility to colorectal cancer in Kashmiri population

1 reference

12 December 2020

Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis

1 reference

12 December 2020

Molecular genetic studies of the adenoma-carcinoma sequence.

1 reference

12 December 2020

GTPase activating proteins: critical regulators of intracellular signaling

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12 December 2020

CYP1A1 polymorphisms and risk of lung cancer in the ethnic Kashmiri population.

1 reference

12 December 2020

Novelty of Axin 2 and lack of Axin 1 gene mutation in colorectal cancer: a study in Kashmiri population

1 reference

12 December 2020

Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

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12 December 2020

Wnt signaling and cancer

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12 December 2020

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

1 reference

12 December 2020

Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study.

1 reference

12 December 2020

Overexpression of axin downregulates TCF-4 and inhibits the development of lung cancer

1 reference

12 December 2020

TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population

1 reference

12 December 2020

NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis

1 reference

12 December 2020

Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk

1 reference

12 December 2020

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans

1 reference

12 December 2020

A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer

1 reference

12 December 2020

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer

1 reference

12 December 2020

DNA repair gene 8-oxoguanine DNA glycosylase Ser326Cys polymorphism and colorectal cancer risk in a Kashmiri population

1 reference

12 December 2020

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors

1 reference

12 December 2020

Structural insights on Smad function in TGFbeta signaling

1 reference

12 December 2020

Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness.

1 reference

12 December 2020

The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients

1 reference

12 December 2020

Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population.

1 reference

12 December 2020

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

1 reference

12 December 2020

Role of the metalloproteinase-7 (181A>G) polymorphism in gastric cancer susceptibility: a case control study in Kashmir valley

1 reference

12 December 2020

Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population

1 reference

12 December 2020

Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population

1 reference

12 December 2020

Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells

1 reference

12 December 2020

NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population

1 reference

12 December 2020

The common germline Arg72Pro polymorphism of p53 and increased longevity in humans

1 reference

12 December 2020

Pattern of cancer at Srinagar (Kashmir)

1 reference

12 December 2020

Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case-control study in an Indian population

1 reference

12 December 2020

On finding flat adenomas: is the search worth the gain?

1 reference

12 December 2020

TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival

1 reference

12 December 2020

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas

1 reference

12 December 2020

APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Mutation pattern of K-ras gene in colorectal cancer patients of Kashmir: a report

1 reference

12 December 2020

The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir

1 reference

12 December 2020

Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis.

1 reference

12 December 2020

p53 mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): a high-incidence area

1 reference

12 December 2020

Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk

1 reference

12 December 2020

10.1007/S13277-013-0692-4

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1031539709

0 references

1 reference