(Q34605511)

3 August 2017

1 reference

title

GTPase activating proteins: critical regulators of intracellular signaling (English)

1 reference

3 August 2017

3

Gideon Bollag

1 reference

3 August 2017

Shane Donovan

1

1 reference

3 August 2017

Kevin M Shannon

series ordinal

2

1 reference

3 August 2017

language of work or name

English

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publication date

1 March 2002

1 reference

Biochimica et Biophysica Acta

3 August 2017

published in

1 reference

3 August 2017

volume

1602

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3 August 2017

issue

1

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3 August 2017

page(s)

23-45

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The GTPase superfamily: a conserved switch for diverse cell functions

3 August 2017

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G proteins, effectors and GAPs: structure and mechanism

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GTPase-activating proteins: helping hands to complement an active site

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NF1 tumor suppressor gene function: narrowing the GAP

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Proteins regulating Ras and its relatives

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A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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7 January 2021

Molecular cloning of two types of GAP complementary DNA from human placenta

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7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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7 January 2021

Catalytic domain of the p120 Ras GAP binds to RAb5 and stimulates its GTPase activity

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7 January 2021

Two SH2 Domains of p120 Ras GTPase-activating Protein Bind Synergistically to Tyrosine Phosphorylated p190 Rho GTPase-activating Protein

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7 January 2021

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

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7 January 2021

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

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7 January 2021

Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein

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7 January 2021

In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase

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7 January 2021

Binding of GAP to activated PDGF receptors

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7 January 2021

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

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7 January 2021

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

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7 January 2021

Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins

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7 January 2021

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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7 January 2021

Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity

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7 January 2021

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

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7 January 2021

Association between GTPase activators for Rho and Ras families.

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7 January 2021

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

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7 January 2021

Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

1 reference

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7 January 2021

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

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7 January 2021

Role of p120 Ras-GAP in directed cell movement

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7 January 2021

The neurofibromatoses. An overview

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mutations in the GAP-related domain impair the ability of neurofibromin to associate with microtubules.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis: loss of heterozygosity for chromosome 17.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

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7 January 2021

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1 reference

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7 January 2021

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function

1 reference

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7 January 2021

Neurofibromatosis type 1 gene mutations in neuroblastoma

1 reference

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7 January 2021

Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1 reference

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7 January 2021

Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

A mouse model for the learning and memory deficits associated with neurofibromatosis type I

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mouse tumor model for neurofibromatosis type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mouse models of tumor development in neurofibromatosis type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Nf1 and Gmcsf interact in myeloid leukemogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Regulators and Effectors of ras Proteins

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7 January 2021

The ras superfamily of small GTP-binding proteins

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7 January 2021

Differential regulation of rasGAP and neurofibromatosis gene product activities

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions

1 reference

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7 January 2021

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

1 reference

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7 January 2021

A novel GTPase-activating protein for R-Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

GapIII, a new brain-enriched member of the GTPase-activating protein family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Heterologous expression and characterization of the human R-ras gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Integrin activation by R-ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

The Rap1 GTPase functions as a regulator of morphogenesis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

GAPs for rho-related GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Increased neutrophil respiratory burst in bcr-null mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1. Evidence for the pleckstrin homology domain functioning as an allosteric site

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Nucleocytoplasmic transport: driving and directing transport

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mutations of signal-transducing G proteins in human disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Two G protein oncogenes in human endocrine tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Structural analysis of the GAP-related domain from neurofibromin and its implications

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

How Ras works: structure of a Rap-Raf complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

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1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

SMART, a simple modular architecture research tool: identification of signaling domains

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

Regulation of actin dynamics: The LIM kinase connection

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900041-5

7 January 2021

10.1016/S0304-419X(01)00041-5

Identifiers

DOI

1 reference

3 August 2017

1 reference