(Q38093645)

28 August 2017

title

Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter (English)

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28 August 2017

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Timothy J Egan

1

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28 August 2017

David Kuter

series ordinal

2

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28 August 2017

publication date

1 April 2013

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28 August 2017

number of pages

15

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inferred from page(s)

published in

Future Microbiology

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28 August 2017

volume

8

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28 August 2017

issue

4

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28 August 2017

page(s)

475-489

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A large focus of naturally acquired Plasmodium knowlesi infections in human beings

28 August 2017

cites work

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Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

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In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).

21 January 2018

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21 January 2018

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Fate of haem iron in the malaria parasite Plasmodium falciparum

21 January 2018

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The crystal structure of superoxide dismutase from Plasmodium falciparum

21 January 2018

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The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification

21 January 2018

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COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.

21 January 2018

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Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites

21 January 2018

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The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

21 January 2018

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Iron(III) protoporphyrin IX complexes of the antimalarial Cinchona alkaloids quinine and quinidine

21 January 2018

1 reference

A nuclear magnetic resonance study of the interactions of antimalarial drugs with porphyrins

21 January 2018

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Solution structures of antimalarial drug-heme complexes

21 January 2018

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Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution

21 January 2018

1 reference

Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine

21 January 2018

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Interactions of quinoline antimalarials with hematin in solution

21 January 2018

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4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

21 January 2018

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Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

21 January 2018

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Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

21 January 2018

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Crystal nucleation, growth, and morphology of the synthetic malaria pigment beta-hematin and the effect thereon by quinoline additives: the malaria pigment as a target of various antimalarial drugs

21 January 2018

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Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design

21 January 2018

1 reference

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance

21 January 2018

1 reference

The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor

21 January 2018

1 reference

On the molecular mechanism of chloroquine's antimalarial action

21 January 2018

1 reference

Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria

21 January 2018

1 reference

Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum

21 January 2018

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Insights into the role of heme in the mechanism of action of antimalarials

21 January 2018

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Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth

21 January 2018

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Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

21 January 2018

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Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position

21 January 2018

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Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth

21 January 2018

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Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.

21 January 2018

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Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.

21 January 2018

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Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin.

21 January 2018

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Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

21 January 2018

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Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

21 January 2018

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Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

21 January 2018

1 reference

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

21 January 2018

1 reference

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

21 January 2018

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Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

21 January 2018

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Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

21 January 2018

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Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

21 January 2018

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Multiple transporters associated with malaria parasite responses to chloroquine and quinine

21 January 2018

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Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

21 January 2018

1 reference

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

21 January 2018

1 reference

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

21 January 2018

1 reference

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective

21 January 2018

1 reference

Chloroquine transport via the malaria parasite's chloroquine resistance transporter

21 January 2018

1 reference

Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine

21 January 2018

1 reference

Drug-resistant malaria: molecular mechanisms and implications for public health

21 January 2018

1 reference

PfCRT and its role in antimalarial drug resistance

21 January 2018

1 reference

PfCRT-mediated drug transport in malarial parasites

21 January 2018

1 reference

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

21 January 2018

1 reference

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

21 January 2018

1 reference

Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

21 January 2018

1 reference

Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives

21 January 2018

1 reference

A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal

21 January 2018

1 reference

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum

21 January 2018

1 reference

Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum.

21 January 2018

1 reference

Synthesis, Structure−Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

21 January 2018

1 reference

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity

21 January 2018

1 reference

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum

21 January 2018

1 reference

Discovery of dual function acridones as a new antimalarial chemotype

21 January 2018

1 reference

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

21 January 2018

1 reference

Reversed chloroquine molecules as a strategy to overcome resistance in malaria

21 January 2018

1 reference

Long QT syndromes and torsade de pointes

21 January 2018

1 reference

Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base

21 January 2018

1 reference

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

21 January 2018

1 reference

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 January 2018

1 reference

Falcipains and other cysteine proteases of malaria parasites

21 January 2018

1 reference

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

21 January 2018

1 reference

Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum

21 January 2018

1 reference

Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism

21 January 2018

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Haemozoin (beta-haematin) biomineralization occurs by self-assembly near the lipid/water interface

21 January 2018

1 reference

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

21 January 2018

1 reference

On the mechanism of chloroquine resistance in Plasmodium falciparum

21 January 2018

1 reference

Generation of a set of simple, interpretable ADMET rules of thumb

21 January 2018

1 reference

12 December 2020

Insecticide-treated bed nets and curtains for preventing malaria

1 reference

12 December 2020

Seven years of regional malaria control collaboration--Mozambique, South Africa, and Swaziland.

1 reference

12 December 2020

Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum

1 reference

12 December 2020

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

1 reference

12 December 2020

Identifiers

DOI

10.2217/FMB.13.18

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28 August 2017

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