(Q37979631)

26 August 2017

title

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics (English)

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26 August 2017

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Robert L Summers

1

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Rowena Martin

object named as

Rowena E Martin

series ordinal

3

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author name string

Megan N Nash

series ordinal

2

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26 August 2017

language of work or name

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1 June 2012

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Cellular and Molecular Life Sciences

26 August 2017

published in

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26 August 2017

volume

69

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26 August 2017

issue

12

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26 August 2017

page(s)

1967-1995

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The economic and social burden of malaria

26 August 2017

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The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

21 January 2018

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Trafficking of the phosphoprotein PfCRT to the digestive vacuolar membrane in Plasmodium falciparum

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Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum

21 January 2018

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A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

21 January 2018

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Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

21 January 2018

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Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

21 January 2018

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Chloroquine transport via the malaria parasite's chloroquine resistance transporter

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Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

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21 January 2018

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21 January 2018

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A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal

21 January 2018

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Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

21 January 2018

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Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross

21 January 2018

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21 January 2018

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A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum

21 January 2018

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21 January 2018

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Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine

21 January 2018

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Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum

21 January 2018

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Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

21 January 2018

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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

21 January 2018

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21 January 2018

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Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance

21 January 2018

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Multiple transporters associated with malaria parasite responses to chloroquine and quinine

21 January 2018

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Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?

21 January 2018

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Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum

21 January 2018

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Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

21 January 2018

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21 January 2018

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Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

21 January 2018

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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

21 January 2018

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21 January 2018

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21 January 2018

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Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa

21 January 2018

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Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda

21 January 2018

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Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative

21 January 2018

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Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children

21 January 2018

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Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania

21 January 2018

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Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

21 January 2018

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Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum

21 January 2018

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Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene

21 January 2018

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Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

21 January 2018

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Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

21 January 2018

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Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda

21 January 2018

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Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro

21 January 2018

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In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon

21 January 2018

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Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

21 January 2018

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The state of the art in anti-malarial drug discovery and development

21 January 2018

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Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro

21 January 2018

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In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax

21 January 2018

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Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum

21 January 2018

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Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria

21 January 2018

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Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine

21 January 2018

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Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

21 January 2018

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Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria

21 January 2018

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Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy

21 January 2018

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A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria

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Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination

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Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum

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21 January 2018

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21 January 2018

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Malaria's drug miracle in danger

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1 reference

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Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Chloroquine resistant Plasmodium falciparum malaria in Guinea-Bissau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Chloroquine is grossly overdosed and overused but well tolerated in Guinea-bissau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Is chloroquine making a comeback?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Antimalarial pharmacokinetics and treatment regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Should chloroquine be laid to rest?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Antimalarial drug toxicity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Anti-malarial drug formulations and novel delivery systems: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Dose‐Dependent Risk of Neutropenia after 7‐Day Courses of Artesunate Monotherapy in Cambodian Patients with AcutePlasmodium falciparumMalaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Drug discovery: Priming the antimalarial pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

New medicines to improve control and contribute to the eradication of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Thousands of chemical starting points for antimalarial lead identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Microbiology. Is the tide turning for new malaria medicines?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Expanding the Antimalarial Drug Arsenal-Now, But How?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Synthesis of new 4-aminoquinolines and quinoline–acridine hybrids as antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Synthesis, Structure−Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Discovery of dual function acridones as a new antimalarial chemotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Selection of a trioxaquine as an antimalarial drug candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: a Philippine study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Molecular analysis of chloroquine resistance in Plasmodium falciparum in Yunnan Province, China

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

High dose chloroquine versus micronized halofantrine in chloroquine-resistant Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Treatment of uncomplicated malaria in children in Guinea-Bissau with chloroquine, quinine, and sulfadoxine-pyrimethamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0906-0

Impact of Plasmodium falciparum malaria on performance and learning: review of the evidence.

21 January 2018

1 reference

12 December 2020

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

1 reference

12 December 2020

Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.

1 reference

12 December 2020

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.

1 reference

12 December 2020

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine

1 reference

12 December 2020

Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro

1 reference

12 December 2020

Antimalarials. 7-Chloro-4-(substituted amino)quinolines

1 reference

12 December 2020

Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau

1 reference

12 December 2020

A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum.

1 reference

12 December 2020

Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design

1 reference

12 December 2020

Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum

1 reference

12 December 2020

Parasitologic and clinical efficacy of 25 and 50 mg/kg of chloroquine for treatment of Plasmodium falciparum malaria in Rwandan children.

1 reference

12 December 2020

Artemisinin Antimalarials: Preserving the "Magic Bullet"

1 reference

12 December 2020

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

1 reference

12 December 2020

Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols

1 reference

12 December 2020

In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.

1 reference

12 December 2020

Short report: polymorphisms in the chloroquine resistance transporter gene in Plasmodium falciparum isolates from Lombok, Indonesia.

1 reference

12 December 2020

Membrane transport in the malaria-infected erythrocyte

1 reference

12 December 2020

pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border

1 reference

12 December 2020

A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro

1 reference

12 December 2020

The economic burden of malaria.

1 reference

12 December 2020

Drug resistance of Plasmodium falciparum in Burundi

1 reference

12 December 2020

The curative action of antimalarial drugs against Plasmodium lophurae in chicks

1 reference

12 December 2020

Clinical testing of new antimalarial compounds

1 reference

12 December 2020

Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin

1 reference

12 December 2020

A case of Plasmodium falciparum malaria contracted in Guinea-Bissau during chemoprophylaxis with chloroquine

1 reference

12 December 2020

A randomized clinical trial with high dose of chloroquine for treatment of Plasmodium falciparum malaria in Brazil

1 reference

12 December 2020

AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE.

1 reference

12 December 2020

Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum

1 reference

12 December 2020

New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates.

1 reference

12 December 2020

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

1 reference

12 December 2020

Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

1 reference

12 December 2020

Treatment of children with Plasmodium falciparum malaria with chloroquine in Guinea-Bissau.

1 reference

12 December 2020

Artemisinin resistance: current status and scenarios for containment

1 reference

12 December 2020

The antimalarial mode of action of chloroquine

1 reference

12 December 2020

Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy

1 reference

12 December 2020

In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas.

1 reference

12 December 2020

10.1007/S00018-011-0906-0

Identifiers

DOI

1 reference

26 August 2017

1 reference