(Q38097492)

28 August 2017

title

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders (English)

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28 August 2017

3

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28 August 2017

Maliheh Safavi

1

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Maryam Baeeri

object named as

Maryam Baeeri

series ordinal

2

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language of work or name

English

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publication date

9 April 2013

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

8

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28 August 2017

issue

6

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28 August 2017

page(s)

733-751

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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

28 August 2017

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Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase

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Identification of human PDE7B, a cAMP-specific phosphodiesterase

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Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase

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T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3

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Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

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Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

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Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors

21 January 2018

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Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo

21 January 2018

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Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

21 January 2018

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Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors

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21 January 2018

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21 January 2018

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21 January 2018

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Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling

21 January 2018

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Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

21 January 2018

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Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

21 January 2018

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Mammalian membrane-bound adenylyl cyclases

21 January 2018

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Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models

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21 January 2018

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21 January 2018

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Phosphodiesterases and compartmentalized cAMP signalling in the heart

21 January 2018

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ABCD of the phosphodiesterase family: interaction and differential activity in COPD

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

21 January 2018

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Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.

21 January 2018

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Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval

21 January 2018

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EPAC proteins transduce diverse cellular actions of cAMP.

21 January 2018

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Role of Epac in brain and heart

21 January 2018

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Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells

21 January 2018

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Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells

21 January 2018

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Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration

21 January 2018

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Immunosuppressive drugs: the first 50 years and a glance forward

21 January 2018

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Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation

21 January 2018

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Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Cytoplasmic cAMP concentrations in intact cardiac myocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

ADMET considerations for phosphodiesterase-5 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Stereoelectronic properties of spiroquinazolinones in differential PDE7 inhibitory activity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

21 January 2018

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Structural basis for the activity of drugs that inhibit phosphodiesterases

21 January 2018

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Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Phosphodiesterase 7A-deficient mice have functional T cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Genomic responses in mouse models poorly mimic human inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors

21 January 2018

1 reference

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CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-alpha]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors

21 January 2018

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Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Virtual screening in drug discovery -- a computational perspective

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.787986

New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.787986

10.1517/17460441.2013.787986

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

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