(Q38097847)

28 August 2017

title

Proteomics and NF-κB: an update (English)

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28 August 2017

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Ellen Niederberger

1

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28 August 2017

Gerd Geisslinger

series ordinal

2

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28 August 2017

publication date

1 April 2013

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Expert Review of Proteomics

28 August 2017

published in

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28 August 2017

volume

10

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28 August 2017

issue

2

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28 August 2017

page(s)

189-204

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The IKK NF-kappa B system: a treasure trove for drug development

28 August 2017

cites work

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IkappaB kinases: key regulators of the NF-kappaB pathway

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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Regulation and function of IKK and IKK-related kinases

21 January 2018

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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

21 January 2018

1 reference

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

21 January 2018

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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

21 January 2018

1 reference

IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

21 January 2018

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Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.

21 January 2018

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Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

21 January 2018

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Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

21 January 2018

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Current insights into the regulation of programmed cell death by NF-kappaB.

21 January 2018

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Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis

21 January 2018

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Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

21 January 2018

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The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia

21 January 2018

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Proteomic analysis of dopamine and α-synuclein interplay in a cellular model of Parkinson's disease pathogenesis

21 January 2018

1 reference

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-κB: a proteomic study

21 January 2018

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Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses

21 January 2018

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21 January 2018

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Proteomics: new perspectives, new biomedical opportunities

21 January 2018

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Charting the NF-κB pathway interactome map

21 January 2018

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Analysis of NF-kappaB signaling pathways by proteomic approaches

21 January 2018

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2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers

21 January 2018

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Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

21 January 2018

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Multidimensional separations-based shotgun proteomics

21 January 2018

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The tandem affinity purification (TAP) method: a general procedure of protein complex purification

21 January 2018

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Charting protein complexes, signaling pathways, and networks in the immune system

21 January 2018

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

21 January 2018

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Analyzing proteome topology and function by automated multidimensional fluorescence microscopy

21 January 2018

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Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing

21 January 2018

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The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest

21 January 2018

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

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Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

21 January 2018

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Expanding the substantial interactome of NEMO using protein microarrays

21 January 2018

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TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling

21 January 2018

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Role of monoubiquitylation on the control of IκBα degradation and NF-κB activity

21 January 2018

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Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner

21 January 2018

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Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells

21 January 2018

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21 January 2018

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Nuclear protein IkappaB-zeta inhibits the activity of STAT3.

21 January 2018

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Proteomic analysis of shear stress-mediated protection from TNF-alpha in endothelial cells

21 January 2018

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14-3-3ε and 14-3-3σ inhibit Toll-like receptor (TLR)-mediated proinflammatory cytokine induction

21 January 2018

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Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil

21 January 2018

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Functional rafts in cell membranes

21 January 2018

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Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide.

21 January 2018

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Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i

21 January 2018

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Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

21 January 2018

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TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways

21 January 2018

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The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation

21 January 2018

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Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling

21 January 2018

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The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor

21 January 2018

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Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha

21 January 2018

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

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Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina

21 January 2018

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ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production

21 January 2018

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Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice

21 January 2018

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Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells

21 January 2018

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Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals changes in the cytoplasmic, nuclear, and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus

21 January 2018

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Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin

21 January 2018

1 reference

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

21 January 2018

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Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts

21 January 2018

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Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production

21 January 2018

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Identification of the cystic fibrosis gene: genetic analysis

21 January 2018

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High abundance protein profiling of cystic fibrosis lung epithelial cells

21 January 2018

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De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells

21 January 2018

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Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

21 January 2018

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Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease

21 January 2018

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Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

21 January 2018

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Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-kappaB pathway and mitotic checkpoint

21 January 2018

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Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles

21 January 2018

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Proteomic profiling between CNE-2 and its strongly metastatic subclone S-18 and functional characterization of HSP27 in metastasis of nasopharyngeal carcinoma

21 January 2018

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RbAp48 is a target of nuclear factor-kappaB activity in thyroid cancer

21 January 2018

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Genes that mediate breast cancer metastasis to the brain

21 January 2018

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Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brain.

21 January 2018

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Biological pathways contributing to organ-specific phenotype of brain metastatic cells

21 January 2018

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Proteomic analysis of cervical cancer cells treated with adenovirus-mediated MDA-7.

21 January 2018

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Comparative proteomic analysis implicates COMMD proteins as Epstein-Barr virus targets in the BL41 Burkitt's lymphoma cell line

21 January 2018

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Protein alteration of HepG2.2.15 cells induced by iron overload

21 January 2018

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Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular pathways and networks involved in metastasis

21 January 2018

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Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes

21 January 2018

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Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications

21 January 2018

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Estimates of the cancer incidence and mortality in Europe in 2006.

21 January 2018

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Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

21 January 2018

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Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers

21 January 2018

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Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells

21 January 2018

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Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis

21 January 2018

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Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell

21 January 2018

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Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation

21 January 2018

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Current treatment of osteosarcoma

21 January 2018

1 reference

Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research

21 January 2018

1 reference

Oncoproteomic analysis reveals co-upregulation of RELA and STAT5 in carboplatin resistant ovarian carcinoma

21 January 2018

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Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium

21 January 2018

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mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells

21 January 2018

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Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: a proteomics approach

21 January 2018

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Proteomic analysis of Terminalia chebula extract-dependent changes in human lymphoblastic T cell protein expression

21 January 2018

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Protein profiling of genomic instability in endometrial cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/EPR.13.5

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28 August 2017

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