(Q38101243)

28 August 2017

title

Speculative strategies for new antibacterials: all roads should not lead to Rome (English)

1 reference

28 August 2017

Stuart Shapiro

1

1 reference

28 August 2017

publication date

24 April 2013

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The Journal of Antibiotics

28 August 2017

published in

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28 August 2017

volume

66

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28 August 2017

issue

7

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28 August 2017

page(s)

371-386

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Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship

28 August 2017

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

21 January 2018

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

21 January 2018

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Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA.

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21 January 2018

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21 January 2018

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21 January 2018

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SODIUM SULPHOMETHYL DERIVATIVES OF POLYMYXINS

21 January 2018

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In Vitro Evaluation of Antibiotic Synergy for Polymyxin B-Resistant Carbapenemase-Producing Klebsiella pneumoniae

21 January 2018

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Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

21 January 2018

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21 January 2018

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21 January 2018

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Structural enzymology of biotin biosynthesis

21 January 2018

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Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues

21 January 2018

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21 January 2018

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Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis.

21 January 2018

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Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

21 January 2018

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Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

21 January 2018

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Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

21 January 2018

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Endogenous production of lipoic acid is essential for mouse development

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

A complex lipoate utilization pathway in Listeria monocytogenes.

21 January 2018

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Lipoic acid metabolism in microbial pathogens.

21 January 2018

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Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase

21 January 2018

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Listeria intracellular growth and virulence require host-derived lipoic acid

21 January 2018

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LplA1-dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence.

21 January 2018

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Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence.

21 January 2018

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Flavogenomics--a genomic and structural view of flavin-dependent proteins

21 January 2018

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Biosynthesis and function of enzymes with covalently bound flavin

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Biosynthesis of riboflavin

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

The riboflavin analog roseoflavin targets an FMN-riboswitch and blocks Listeria monocytogenes growth, but also stimulates virulence gene-expression and infection

21 January 2018

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Formation of roseoflavin from 8-amino- and 8-methylamino-8-demethyl-D-riboflavin

21 January 2018

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The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase.

21 January 2018

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Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

21 January 2018

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Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis

21 January 2018

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The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets?

21 January 2018

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Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs

21 January 2018

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Rugulactone and its analogues exert antibacterial effects through multiple mechanisms including inhibition of thiamine biosynthesis

21 January 2018

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Coenzyme A biosynthesis: an antimicrobial drug target

21 January 2018

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The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

21 January 2018

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Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

21 January 2018

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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis

21 January 2018

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Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides

21 January 2018

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Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates

21 January 2018

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Epidemic of Klebsiella pneumoniae ST11 clone coproducing KPC-2 and 16S rRNA methylase RmtB in a Chinese University Hospital

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms

21 January 2018

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Genetic features of blaNDM-1-positive Enterobacteriaceae

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

A carbon-13 nuclear magnetic resonance study of the 3'-terminus of 16S ribosomal RNA of Escherichia coli specifically labeled with carbon-13 in the methylgroups of the m6(2)Am6(2)A sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Erythromycin resistance by ribosome modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Macrolide resistance based on the Erm-mediated rRNA methylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Host range of the ermF rRNA methylase gene in bacteria of human and animal origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Update on the major clonal types of methicillin-resistant Staphylococcus aureus in the Czech Republic

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

erm(C) is the predominant genetic determinant for the expression of resistance to macrolides among methicillin-resistant Staphylococcus aureus clinical isolates in Greece

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Macrolide resistance genes in Enterococcus spp

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Emergence and spread of cfr-mediated multiresistance in staphylococci: an interdisciplinary challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The emerging problem of linezolid-resistant Staphylococcus

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Linezolid dependence in Staphylococcus epidermidis bloodstream isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

S-adenosylmethionine in liver health, injury, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Virtual screening and experimental verification to identify potential inhibitors of the ErmC methyltransferase responsible for bacterial resistance against macrolide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Modulation of erm methyltransferase activity by peptides derived from phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Scintillation proximity assay for measurement of RNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Mini-F plasmid genes that couple host cell division to plasmid proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Bacterial toxin-antitoxin systems: Translation inhibitors everywhere

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Regulation of growth and death in Escherichia coli by toxin-antitoxin systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Toxin-antitoxin systems in bacteria and archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Toxins-antitoxins: diversity, evolution and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2013.27

Chromosomal bacterial type II toxin-antitoxin systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Programmed cell death in prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Molecular control of bacterial death and lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The Escherichia coli mazEF suicide module mediates thymineless death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Chromosomal toxin-antitoxin systems may act as antiaddiction modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Artificial activation of toxin-antitoxin systems as an antibacterial strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

A toxin-antitoxin module as a target for antimicrobial development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Persister cells: molecular mechanisms related to antibiotic tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

New-found fundamentals of bacterial persistence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Bacterial persistence by RNA endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Arrested protein synthesis increases persister-like cell formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Coin hoards speak of population declines in Ancient Rome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Nosocomial outbreak of methicillin- and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

Polyketide synthesis: prospects for hybrid antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

In-vitro study of the synergy between beta-lactam antibiotics and glycopeptides against enterococci

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

First novel anti-tuberculosis drug in 40 years

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Substrate- and antibiotic-binding sites at the peptidyl-transferase centre of Escherichia coli ribosomes. Studies on the chloramphenicol. lincomycin and erythromycin sites

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Sparsophenicol: a new synthetic hybrid antibiotic inhibiting ribosomal peptide synthesis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Activity of polymyxin B and the novel polymyxin analogue CB-182,804 against contemporary Gram-negative pathogens in New York City

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Modification of experimental aminoglycoside nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Studies on a new amino acid antibiotic, amiclenomycin.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Biological studies of amiclenomycin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

ROSEOFLAVIN, A NEW ANTIMICROBIAL PIGMENT FROM STREPTOMYCES

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Evaluation of CoA biosynthesis proteins of Mycobacterium tuberculosis as potential drug targets

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Detection of the staphylococcal multiresistance gene cfr in Proteus vulgaris of food animal origin

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

S-Adenosylmethionine and methylation

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Assays to detect and characterize synthetic agents that inhibit the ErmC methyltransferase.

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Modeling of the structure and interactions of the B. anthracis antitoxin, MoxX: deletion mutant studies highlight its modular structure and repressor function

1 reference

https://api.crossref.org/works/10.1038%2FJA.2013.27

7 January 2021

Identifiers

DOI

10.1038/JA.2013.27

1 reference

Dimensions Publication ID

28 August 2017

1010253566

0 references

1 reference