(Q38102568)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

The molecular and cell biology of pediatric low-grade gliomas (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Y-H Chen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

language of work or name

English

0 references

publication date

29 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

2019-2026

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2013.148

29 February 2020

exact match

0 references

cites work

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Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.

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Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.

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Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.

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Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations.

21 January 2018

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Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.

21 January 2018

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Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

21 January 2018

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

21 January 2018

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Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

21 January 2018

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A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity

21 January 2018

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Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1

21 January 2018

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Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues.

21 January 2018

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Developmental regulation of a neuron-specific neurofibromatosis 1 isoform.

21 January 2018

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Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

21 January 2018

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Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

21 January 2018

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The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

21 January 2018

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21 January 2018

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Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

21 January 2018

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Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene

21 January 2018

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Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

21 January 2018

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Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.

21 January 2018

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Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.

21 January 2018

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Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

21 January 2018

1 reference

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Subtypes of medulloblastoma have distinct developmental origins

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Radial glia cells are candidate stem cells of ependymoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Radial glia give rise to adult neural stem cells in the subventricular zone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Molecular subgroups of medulloblastoma: the current consensus

21 January 2018

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

21 January 2018

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Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model

21 January 2018

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Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

21 January 2018

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Mosaic analysis with double markers reveals tumor cell of origin in glioma

21 January 2018

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Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Asymmetry-defective oligodendrocyte progenitors are glioma precursors

21 January 2018

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Epidermal growth factor receptor and Ink4a/Arf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Innate neural stem cell heterogeneity determines the patterning of glioma formation in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Constitutive activation of Raf-1 induces glioma formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

A perivascular niche for brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Microglia as a source and target of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Microglia function in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Microglia promote the death of developing Purkinje cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Tumor-associated macrophages press the angiogenic switch in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Astrocytic regulation of human monocytic/microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Microglia-derived TGF-beta as an important regulator of glioblastoma invasion--an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Expression of the new CXCL12 receptor, CXCR7, in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Neurofibromin regulates G protein-stimulated adenylyl cyclase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Survival and long-term health and cognitive outcomes after low-grade glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children's Oncology Group.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Endocrine outcome in long-term survivors of childhood brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.148

Natural history of neurofibromatosis 1-associated optic nerve glioma in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

The Neurofibromatosis 1 Gene Product Neurofibromin Regulates Pituitary Adenylate Cyclase-Activating Polypeptide-Mediated Signaling in Astrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

Prognostic factors of CNS tumours in Neurofibromatosis 1 (NF1): a retrospective study of 104 patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.148

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2013.148

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23624918%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 February 2020

0 references

1 reference