(Q38108538)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

1

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1 March 2020

author name string

Dominic D Frank

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

P Hande Özdinler

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

publication date

1 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

Cell Biochemistry and Biophysics

1 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

67

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

45-53

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

1 March 2020

cites work

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The ubiquitin system, an immense realm

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The new landscape of protein ubiquitination

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21 January 2018

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21 January 2018

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Balancing act: deubiquitinating enzymes in the nervous system

21 January 2018

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UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein

21 January 2018

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Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells

21 January 2018

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Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

21 January 2018

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Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening

21 January 2018

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

21 January 2018

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

21 January 2018

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Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.

21 January 2018

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Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration

21 January 2018

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The functions of UCH-L1 and its relation to neurodegenerative diseases

21 January 2018

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Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance

21 January 2018

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The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.

21 January 2018

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Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation

21 January 2018

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Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.

21 January 2018

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Proteasome deubiquitinases as novel targets for cancer therapy

21 January 2018

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Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes

21 January 2018

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The ubiquitin+proteasome protein degradation pathway as a therapeutic strategy in the treatment of solid tumor malignancies

21 January 2018

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The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib.

21 January 2018

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The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

21 January 2018

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The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

21 January 2018

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A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis.

21 January 2018

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PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma

21 January 2018

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CpG island hypermethylation in progression of esophageal and gastric cancer

21 January 2018

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Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.

21 January 2018

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Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.

21 January 2018

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Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

21 January 2018

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Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling

21 January 2018

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Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes

21 January 2018

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Protein quality control in neurodegenerative disease

21 January 2018

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Neurological disease: UPS stops delivering!

21 January 2018

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100 years of Lewy pathology

21 January 2018

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21 January 2018

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21 January 2018

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An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

21 January 2018

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Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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21 January 2018

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Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

21 January 2018

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Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14

21 January 2018

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21 January 2018

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21 January 2018

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Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.

21 January 2018

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Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

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Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.

21 January 2018

1 reference

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Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

UCHL-1 is not a Parkinson's disease susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

UCHL1 is a Parkinson's disease susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Exome sequencing reveals VCP mutations as a cause of familial ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

21 January 2018

1 reference

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

21 January 2018

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Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

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The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

21 January 2018

1 reference

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The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.

21 January 2018

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Large-scale mapping of human protein-protein interactions by mass spectrometry

21 January 2018

1 reference

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Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen and angiogenin interact with common host proteins, including annexin A2, which is essential for survival of latently infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Small-fiber neuropathy in patients with ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9631-7

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

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10.1007/S12013-013-9631-7

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 March 2020

1043738191

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23695785%20AND%20SRC:MED&resulttype=core&format=json