(Q38109094)

29 August 2017

Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients (English)

1 reference

Manfred Schubert-Zsilavecz

29 August 2017

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1 reference

series ordinal

2

object named as

Manfred Schubert-Zsilavecz

1 reference

29 August 2017

Christian Ude

1

1 reference

PubMed ID

23703577

29 August 2017

Mario Wurglics

series ordinal

3

1 reference

29 August 2017

1 September 2013

1 reference

Clinical Pharmacokinetics

29 August 2017

1 reference

29 August 2017

52

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29 August 2017

9

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29 August 2017

727-749

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https://scigraph.springernature.com/pub.10.1007/s40262-013-0074-5

29 August 2017

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Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.

21 January 2018

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Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality?

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Oxidative stress in diabetes and Alzheimer's disease

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Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons

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Efficacy and tolerability of Ginkgo biloba extract EGb 761 by type of dementia: analyses of a randomised controlled trial.

21 January 2018

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Ginkgo biloba for prevention of dementia: a randomized controlled trial

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Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients

21 January 2018

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Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications

21 January 2018

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The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease.

21 January 2018

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Biology and chemistry of Ginkgo biloba

21 January 2018

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Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?

21 January 2018

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Chemical analysis of Ginkgo biloba leaves and extracts.

21 January 2018

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Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

21 January 2018

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[Fundamentals of therapeutic application of EGb 761].

21 January 2018

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LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia

21 January 2018

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Terpene trilactones from Gingko biloba: from ancient times to the 21st century

21 January 2018

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Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death.

21 January 2018

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Chemistry and biology of terpene trilactones from Ginkgo biloba

21 January 2018

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Studies on molecular mechanisms of Ginkgo biloba extract

21 January 2018

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The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF).

21 January 2018

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Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death.

21 January 2018

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Lipid signaling: sleep, synaptic plasticity, and neuroprotection

21 January 2018

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Ginkgolide B preferentially blocks chloride channels formed by heteromeric glycine receptors in hippocampal pyramidal neurons of rat.

21 January 2018

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The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors

21 January 2018

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The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands.

21 January 2018

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Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.

21 January 2018

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Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

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Transcriptional suppression of the adrenal cortical peripheral-type benzodiazepine receptor gene and inhibition of steroid synthesis by ginkgolide B.

21 January 2018

1 reference

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Identification of the adrenocorticotropin and ginkgolide B-regulated 90-kilodalton protein (p90) in adrenocortical cells as a serotransferrin precursor protein homolog (adrenotransferrin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

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Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

21 January 2018

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Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba.

21 January 2018

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Role of GABAergic antagonism in the neuroprotective effects of bilobalide.

21 January 2018

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Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide

21 January 2018

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Bilobalide and neuroprotection

21 January 2018

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Neuroprotective effects of Ginkgo biloba extract

21 January 2018

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Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Interactions between herbal medicines and prescribed drugs: an updated systematic review

21 January 2018

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Induction of cytochrome P450s by terpene trilactones and flavonoids of theGinkgo bilobaextract EGb 761 in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Influence of the Ginkgo extract EGb 761 on rat liver cytochrome P450 and steroid metabolism and excretion in rats and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Antioxidant flavonols and coronary heart disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Ginkgo biloba: specificity of neuropsychological improvement--a selective review in search of differential effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Tea polyphenol inhibits allostimulation in mixed lymphocyte culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Improvement of auditory discrimination learning by Ginkgo biloba extract EGb 761.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Fingerprint profile of Ginkgo biloba nutritional supplements by LC/ESI-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Validation of an LC-MS/MS assay of terpene trilactones in Ginkgo biloba extracts and pharmaceutical formulations through standard addition method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Determination of quercetin and kaempferol in human urine after orally administrated tablet of ginkgo biloba extract by HPLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of terpene lactones in plasma of animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Pharmacokinetics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Pharmacokinetics and bioavailability of quercetin glycosides in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Multiple-Dose Administration of Ginkgo biloba Did Not Affect Cytochrome P-450 2D6 or 3A4 Activity in Normal Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Studies on interactions between functional foods or dietary supplements and medicines. III. Effects of ginkgo biloba leaf extract on the pharmacokinetics of nifedipine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Sensitive and selective liquid chromatography-electrospray ionization mass spectrometry analysis of ginkgolide B in dog plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Quantification of allergenic urushiols in extracts of Ginkgo biloba leaves, in simple one-step extracts and refined manufactured material (EGb 761).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

In vivoBiodistribution of Ginkgolide B, a Constituent ofGinkgo biloba, Visualized by MicroPET

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40262-013-0074-5

[Ginkgo extract in people with declining mental performance]

21 January 2018

1 reference

12 December 2020

Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761

1 reference

12 December 2020

[Absorption, distribution and elimination of a labelled extract of Ginkgo biloba leaves in the rat]

1 reference

12 December 2020

Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects

1 reference

12 December 2020

Determination of active components of Ginkgo biloba in human urine by capillary high-performance liquid chromatography/mass spectrometry with on-line column-switching purification

1 reference

12 December 2020

Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man

1 reference

12 December 2020

[Pharmacokinetic properties of Bilobalide and Ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761)].

1 reference

12 December 2020

Pharmacokinetics of Ginkgo biloba extracts

1 reference

12 December 2020

Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs

1 reference

12 December 2020

Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats.

1 reference

12 December 2020

Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry

1 reference

12 December 2020

[Ginkgo biloba extract EGb 761 in the treatment of dementia: evidence of efficacy and tolerability].

1 reference

12 December 2020

Protection of mitochondrial respiration activity by bilobalide

1 reference

12 December 2020

Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine

1 reference

12 December 2020

Bioavailability of ginkgolides and bilobalide from extracts of ginkgo biloba using GC/MS

1 reference

12 December 2020

The sensitizing capacity of ginkgolic acids in guinea pigs

1 reference

12 December 2020

Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators

1 reference

12 December 2020

Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus

1 reference

12 December 2020

Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.

1 reference

12 December 2020

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease

1 reference

12 December 2020

Ginkgo biloba for cognitive impairment and dementia

1 reference

12 December 2020

Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes

1 reference

12 December 2020

The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors

1 reference

12 December 2020

Identification of flavonoid metabolites after oral administration to rats of a Ginkgo biloba extract

1 reference

12 December 2020

Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress.

1 reference

12 December 2020

Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers

1 reference

12 December 2020

Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death

1 reference

12 December 2020

Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide

1 reference

12 December 2020

Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L.

1 reference

12 December 2020

Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats

1 reference

12 December 2020

Comparative pharmacokinetics and bioavailability of flavonoid glycosides of Ginkgo biloba after a single oral administration of three formulations to healthy volunteers

1 reference

12 December 2020

Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties

1 reference

12 December 2020

Identification of Gingko biloba flavonol metabolites after oral administration to humans

1 reference

12 December 2020

Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity

1 reference

12 December 2020

Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761

1 reference

12 December 2020

Effect of Ginkgo biloba (EGb 761) on differential gene expression.

1 reference

12 December 2020

Ginkgo biloba and ginkgotoxin

1 reference

12 December 2020

Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers

1 reference

12 December 2020

Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial

1 reference

12 December 2020

Pharmacokinetics and bioavailability of a Ginkgo biloba extract

1 reference

12 December 2020

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

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12 December 2020

The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man

1 reference

12 December 2020

A review: inflammatory process in Alzheimer's disease, role of cytokines.

1 reference

12 December 2020

Solid-phase extraction and gas chromatography-mass spectrometry determination of kaempferol and quercetin in human urine after consumption of Ginkgo biloba tablets

1 reference

12 December 2020

[Chemistry, pharmacokinetics and metabolism of ginkgo extract]

1 reference

12 December 2020

St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.

1 reference

12 December 2020

Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease

1 reference

12 December 2020

Ginkgo biloba extract: from molecular mechanisms to the treatment of Alzhelmer's disease

1 reference

12 December 2020

Plasma and brain levels of terpene trilactones in rats after an oral single dose of standardized Ginkgo biloba extract EGb 761®

1 reference

12 December 2020

A brief history of EGb 761 and its therapeutic uses.

1 reference

12 December 2020

[Bleeding caused by Ginkgo biloba extract?]

1 reference

12 December 2020

Oxidative stress and Alzheimer disease

1 reference

12 December 2020

10.1007/S40262-013-0074-5

Identifiers

DOI

1 reference

PubMed ID

23703577

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23703577