(Q38110421)

29 August 2017

Integrin inactivators: balancing cellular functions in vitro and in vivo (English)

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29 August 2017

4

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29 August 2017

Nicola De Franceschi

3

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Jeroen Pouwels

object named as

Jeroen Pouwels

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2

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author name string

Daniel Bouvard

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1

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29 August 2017

30 May 2013

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Nature Reviews Molecular Cell Biology

29 August 2017

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29 August 2017

14

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29 August 2017

7

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29 August 2017

430-442

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https://scigraph.springernature.com/pub.10.1038/nrm3599

29 August 2017

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cites work

Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

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Functional atlas of the integrin adhesome

31 March 2020

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Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes

31 March 2020

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United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.

31 March 2020

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Integrins and extracellular matrix in mechanotransduction

31 March 2020

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Assembly and disassembly of cell matrix adhesions

31 March 2020

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Distinct recycling of active and inactive β1 integrins

31 March 2020

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Integrin inside-out signaling and the immunological synapse

31 March 2020

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The final steps of integrin activation: the end game

31 March 2020

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SHARPIN is an endogenous inhibitor of β1-integrin activation

31 March 2020

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Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

31 March 2020

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Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration

31 March 2020

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Regulation of integrin activation

31 March 2020

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Mechanical control of integrin-mediated adhesion and signaling

31 March 2020

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ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin

31 March 2020

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Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling

31 March 2020

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Structural basis of integrin activation by talin

31 March 2020

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The molecular basis of filamin binding to integrins and competition with talin

31 March 2020

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Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

31 March 2020

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Negative regulators of integrin activity

31 March 2020

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The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin

31 March 2020

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Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.

31 March 2020

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The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling

31 March 2020

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Filamins regulate cell spreading and initiation of cell migration

31 March 2020

1 reference

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

31 March 2020

1 reference

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.

31 March 2020

1 reference

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

31 March 2020

1 reference

Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity

31 March 2020

1 reference

The tail of integrins, talin, and kindlins

31 March 2020

1 reference

Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition

31 March 2020

1 reference

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

31 March 2020

1 reference

Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein

31 March 2020

1 reference

Defective osteoblast function in ICAP-1-deficient mice

31 March 2020

1 reference

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

31 March 2020

1 reference

An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding

31 March 2020

1 reference

SHARPIN is a key regulator of immune and inflammatory responses

31 March 2020

1 reference

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

31 March 2020

1 reference

Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

31 March 2020

1 reference

Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src

31 March 2020

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Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.

31 March 2020

1 reference

Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain

31 March 2020

1 reference

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

1 reference

Regulation of integrin activity and signalling

31 March 2020

1 reference

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

31 March 2020

1 reference

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

31 March 2020

1 reference

Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

31 March 2020

1 reference

The RSK family of kinases: emerging roles in cellular signalling

31 March 2020

1 reference

RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration

31 March 2020

1 reference

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

31 March 2020

1 reference

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

31 March 2020

1 reference

A functional genetic screen reveals new regulators of β1-integrin activity

31 March 2020

1 reference

Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

31 March 2020

1 reference

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

31 March 2020

1 reference

Polymerizing actin fibers position integrins primed to probe for adhesion sites

31 March 2020

1 reference

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

31 March 2020

1 reference

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

31 March 2020

1 reference

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

31 March 2020

1 reference

FAK promotes recruitment of talin to nascent adhesions to control cell motility

31 March 2020

1 reference

Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

31 March 2020

1 reference

Stretching single talin rod molecules activates vinculin binding

31 March 2020

1 reference

Demonstration of catch bonds between an integrin and its ligand.

31 March 2020

1 reference

Mechanically activated integrin switch controls alpha5beta1 function

31 March 2020

1 reference

Structure and function of focal adhesions

31 March 2020

1 reference

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins

31 March 2020

1 reference

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

31 March 2020

1 reference

Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking.

31 March 2020

1 reference

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

31 March 2020

1 reference

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

31 March 2020

1 reference

Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes

31 March 2020

1 reference

The N-terminal half of talin2 is sufficient for mouse development and survival

31 March 2020

1 reference

Disruption of the talin gene arrests mouse development at the gastrulation stage

31 March 2020

1 reference

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

31 March 2020

1 reference

Kindlin-2 controls bidirectional signaling of integrins

31 March 2020

1 reference

Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

31 March 2020

1 reference

Kindlin-3 is essential for integrin activation and platelet aggregation

31 March 2020

1 reference

Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction

31 March 2020

1 reference

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

31 March 2020

1 reference

Talin is essential for integrin function in Drosophila

31 March 2020

1 reference

Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils

31 March 2020

1 reference

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development

31 March 2020

1 reference

Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice

31 March 2020

1 reference

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

31 March 2020

1 reference

Loss-of-function of SHARPIN causes an osteopenic phenotype in mice

31 March 2020

1 reference

Unique and redundant functions of integrins in the epidermis.

31 March 2020

1 reference

Linear ubiquitination prevents inflammation and regulates immune signalling

31 March 2020

1 reference

Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand

31 March 2020

1 reference

Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development

31 March 2020

1 reference

Genetic analysis of beta1 integrin "activation motifs" in mice

31 March 2020

1 reference

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins

31 March 2020

1 reference

In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines

31 March 2020

1 reference

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation

31 March 2020

1 reference

Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

31 March 2020

1 reference

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia

31 March 2020

1 reference

A molecular and clinical study of Larsen syndrome caused by mutations in FLNB

31 March 2020

1 reference

Filamin A: phenotypic diversity

31 March 2020

1 reference

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

31 March 2020

1 reference

Filamins in cell signaling, transcription and organ development

31 March 2020

1 reference

Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.

31 March 2020

1 reference

An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.

31 March 2020

1 reference

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

31 March 2020

1 reference

Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function

31 March 2020

1 reference

Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

31 March 2020

1 reference

Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer

31 March 2020

1 reference

CD9 expression in gastric cancer and its significance

31 March 2020

1 reference

A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.

31 March 2020

1 reference

Significance of talin in cancer progression and metastasis

31 March 2020

1 reference

The primacy of β1 integrin activation in the metastatic cascade

31 March 2020

1 reference

Newly identified tumor-associated role of human Sharpin

31 March 2020

1 reference

Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism

31 March 2020

1 reference

Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography

31 March 2020

1 reference

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

31 March 2020

1 reference

Talin activates integrins by altering the topology of the β transmembrane domain

31 March 2020

1 reference

Integrin structure, activation, and interactions

31 March 2020

1 reference

Targeting and transport: how microtubules control focal adhesion dynamics

31 March 2020

1 reference

Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23719537

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23719537

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3599

1 reference

PubMed ID

23719537

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23719537